7 8 Dihydroxyflavone 


When it comes to cutting-edge research chemicals, one compound has been making waves in the scientific community: 7,8 Dihydroxyflavone (7,8-DHF). With its unique properties and promising potential, 7,8-DHF has emerged as a sought-after substance for researchers exploring the intricate workings of the brain and its cognitive effects. 

Derived from natural sources like Godmania aesculifolia, Tridax procumbens, and primula leaves, 7,8-DHF possesses a chemical formula of C15H10O4 and a molecular weight of 254.24g/mol. Recent studies have identified this compound as a promising therapeutic target for BDNF-TrkB signaling, a crucial pathway involved in brain health and cognitive function  [R].

It is important to note that 7,8-DHF is primarily intended for research purposes and is not promoted for human use. Due to its low oral bioavailability and rapid degradation in the liver , 7,8-DHF undergoes extensive first pass metabolism, resulting in minimal amounts of the compound reaching systemic circulation [R]


Key Features

RCD.Bio offers 7,8 Dihydroxyflavone for sale with the following specifications:

  • A purity of 99%, verified by first and third-party laboratory testing.
  • Available in 1g in powder form.

How 7,8 Dihydroxyflavone Works?

7,8-Dihydroxyflavone (7,8-DHF) is a flavonoid that has shown the ability to cross the blood-brain barrier. This means it can potentially reach the brain and interact with specific receptors and signaling pathways. One of its main actions is selectively activating tyrosine kinase receptor B (trkb) receptors. By doing so, it mimics the effects of brain-derived neurotrophic factor (BDNF), a protein known for its role in promoting the growth and survival of neurons in the brain.[R]

The activation of trkb receptors by 7,8-DHF triggers downstream signaling pathways that play a crucial role in supporting the health and functioning of neurons. This leads to various neuroprotective benefits, which help protect and maintain the well-being of brain cells. In animal studies, 7,8-DHF has also been found to aid in the restoration of neural connections, further highlighting its potential as a therapeutic agent for neurological conditions.[R]

7,8-Dihydroxyflavone has attracted attention for its potential health benefits. Research has explored its possible applications in the possible treatment of various medical conditions, including cancer, Alzheimer’s disease, depression, and obesity. However, it is important to note that the understanding of the effects of 7,8-DHF on human health is still limited, and further research is needed to fully comprehend its potential and safety.[R]

When research subjects were administered 7,8-DHF is rapidly broken down in the liver. This process, known as first-pass metabolism, significantly reduces the amount of the compound that enters systemic circulation. Consequently, it has a low oral bioavailability, meaning that only a small portion of the ingested 7,8-DHF reaches the target tissues in subjects. This limitation highlights the need for alternative administration methods or formulations that can improved bioavailability and maximize its therapeutic potential.In research settings, 7,8-DHF is commonly administered through sublingual administration, ensuring efficient absorption and delivery to the brain.

The scientific basis behind the benefits of 7,8 Dihydroxyflavone

Studies on the possible use of 7,8 Dihydroxyflavone have been undertaken in both human and animal models. The following are a few of the pertinent findings:

Neurodevelopmental Disorders 

Neurodevelopmental disorders encompass a range of conditions that arise due to abnormalities in the development of the central nervous system. These disorders can have a significant impact on an individual’s cognitive, social, and emotional functioning. One crucial factor in brain growth is a neurotrophin called brain-derived neurotrophic factor (BDNF).

Research suggests that increasing BDNF signaling could potentially be a valuable approach in preventing, mitigating, or even reversing abnormal neurodevelopmental processes influenced by various genetic or environmental factors. In a pre-clinical study, scientists explored the possibility of using a recently discovered BDNF-mimetic, known as 7,8-dihydroxyflavone (7,8-DHF), to activate the BDNF pathway effectively and safely in the possible treatment of neurodevelopmental disorders, despite the challenges encountered in such endeavors.[R]

Neuroprotective effects for Parkinson’s disease

Parkinson’s disease (PD) is a neurodegenerative disorder characterized by the progressive loss of dopaminergic neurons in the midbrain. Researchers have investigated the potential neuroprotective effects of 7,8-dihydroxyflavone (7,8-DHF) on monkey models with Parkinson’s disease.

In a study, monkeys were orally administered 7,8-DHF, which was then absorbed and converted into a compound called 7-hydroxy-8-methoxyflavone. The half-life of 7,8-DHF in monkey plasma was found to be between 4 to 8 hours. Importantly, even seven months after receiving 7,8-DHF treatment at a dosage of 30 mg/kg/day, the monkeys remained healthy. One significant finding was that 7,8-DHF treatment reduced the neurotoxic effects of a compound called MPP+. This reduction in neurotoxicity helped prevent the gradual degeneration of midbrain dopaminergic neurons, which are specifically affected in Parkinson’s disease. These results suggest that 7,8-DHF could potentially be developed into a pharmacological drug for Parkinson’s disease.[R]

While these promising results have been observed in monkey models, it is crucial to note that further studies are needed to understand how neurogenetive effects occur in 7,8-dihydroxyflavone , also the effects on how it exert cognitive effects in human. The transition from animal models to human subjects is a complex process, and additional research is necessary to assess the safety, efficacy, and potential side effects of 7,8-DHF in humans.

Improved memory and learning

A crucial regulator of how neurons in the central nervous system (CNS) live and change is a protein called brain-derived neurotrophic factor (BDNF). Since depression and dementia are linked to neurodegeneration, there has been an increase in interest in the function of BDNF in both conditions.

In the current study, the impact of 7,8-DHF on the mechanisms underlying memory consolidation was examined. Rats and mice that were given 7,8-DHF performed better on an object recognition task when compared to controls. of previously taught objects in the task’s context. Both right away and three hours after learning, this effect was noticeable.

When BDNF/TrkB-signaling has been boosted by the administration of 7,8-DHF, powerful antidepressant effects are noticeable [this study implies that 7,8-DHF might be a promising treatment target for dementia]. The results of this study suggest that 7,8-DHF may be a promising treatment target for dementia. [R]

It’s crucial to remember that while some of these health advantages have been demonstrated in mice with cognitively challenged brains, more research is necessary to discover whether they also have an impact on the health of the human brain as well as in conditions such as traumatic brain injury.

Reduced Anxiety and Depression

In a study, 7,8-dihydroxyflavone (7,8-DHF) demonstrated the ability to alleviate depressive and partially anxious symptoms induced by chronic mild stress (CMS). The study conducted on rats revealed that 7,8-DHF significantly increased the levels of serum corticosterone and hippocampal brain-derived neurotrophic factor (BDNF) in the CMS-subjected rats. These findings suggest that the antidepressant and partial anxiolytic effects of 7,8-DHF may be attributed to its impact on corticosterone and BDNF levels. This study highlights the potential of using the TrkB agonist 7,8-DHF as a treatment for depression.

One of the notable advantages of chronic systemic treatment with 7,8-DHF is its ability to target brain pathologies associated with depression, characterized by dysregulated BDNF levels and activity in the hypothalamic-pituitary-adrenal (HPA) axis. This approach offers a more feasible and less invasive alternative to methods such as viral or recombinant protein delivery for chronic treatment of depression-related brain abnormalities.[R]

Other studies have demonstrated that 7,8-DHF can increase the release of neurotransmitters by neurons, resulting in restore communication between them. This mechanism of action is believed to contribute to the antidepressant effects of 7,8-DHF. It is important to note that while these health benefits have been observed in animal studies, further research is necessary to determine the effects of 7,8-dihydroxyflavone in humans. Comprehensive review research is needed to gather more evidence on the potential benefits and risks of 7,8-DHF in human subjects. 

Anti-inflammatory Effects

Cell culture was used to investigate the cellular and molecular processes of 7,8-DHF’s anti-inflammatory effects. According to the research, 7,8-DHF’s ability to decrease quantity of inflammatory is likely connected to the negative control of MAPK activation and the downregulation of iNOS, COX-2, and IL-1 in RAW264.7 cells as a result of NF-B suppression. Therefore, 7,8-DHF might be a cutting-edge therapeutic drug for the avoidance of a number of inflammatory disorders. [R]

To fully comprehend the anti-inflammatory properties of 7,8-DHF, more research is required to completely understand its mechanisms of action and possible therapeutic uses. Furthermore, the safety and long-term implications of consuming 7,8-DHF as a food supplement have not been adequately investigated.

Alcohol and High-fat Diet (HFD)

The molecular mechanism of 7,8-DHF in rats against alcohol and a high-fat diet (HFD)-induced memory impairments was investigated in a study. According to research, 7,8-DHF’s special antioxidant, anti-inflammatory, and anti-apoptotic capabilities ( cell death) , as well as stimulation of the TrkB/BDNF signaling pathway in the hippocampus, helped rats with memory problems brought on by alcohol and HFDs. [R]

However, since the negative effects of 7,8 Dihydroxyflavone need to be more thoroughly examined before intended usage, it should not be used to diagnose, treat, or cure any suspected medical conditions


It may be possible to delay the onset of obesity by repeatedly activating the brain-derived neurotrophic factor (BDNF) TrkB receptor, however validation is challenging due to BDNF’s short half-life and lack of bioavailability. Female mice are adequately shielded from diet-induced obesity by the BDNF mimic 7,8-dihydroxyflavone’s activation of muscle TrkB. [R]

To fully comprehend the impact of 7,8-DHF on obesity and related health issues, more research is necessary.

As a dietary supplement

When ingested orally, nutraceuticals—bioactive substances that can be found in food—are said to have beneficial benefits on one’s health. Due to its potential to increase bioavailability, 7,8 dihydroxyflavone is a potential potent future dietary supplement that has been gaining favor recently. In a study, it was discovered that utilizing DHF-Z-S nanoparticles increased the storage stability and in vitro bioaccessibility effect of 7,8-DHF. The research’s conclusions might open the door to the development of novel 7,8-DHF delivery technologies that are appropriate for usage in dietary supplements and functional foods. [R]


This material is being provided for educational reasons only; it is not intended to be taken as medical advice.7,8-DHF is not meant for human consumption and is only meant for use in laboratories as a research chemical.

Potential side effects

Although 7,8-DHF has a good safety profile according to preclinical investigations, it’s yet unclear how it might affect humans. When examining its use in people, it is crucial to proceed cautiously and keep an eye out for any potential negative effects, just like with any novel substance.

Based on its mode of action and effects on the TrkB receptor, the compound 7,8-DHF may cause some unwanted consequences, such as headaches, insomnia, and gastrointestinal issues. [R] [R] [R]

Further research is necessary to establish suitable dose and safety standards for the use of 7,8-DHF in combination with other drugs as well as to better understand the potential drug interactions involving it.


Among the plant species that contain 7,8-Dihydroxyflavone (7,8-DHF), there are Godmania aesculifolia, coatbuttons (tridax daisy), and primula tree leaves. It has been demonstrated to be both orally active and blood-brain barrier-crossing. Potential therapeutic uses for 7,8-DHF include treating a variety of CNS conditions. In numerous investigations, it has been found to increase learning capacity, improve memory, and minimize motor damage. 7,8-DHF works as a nootropic and neuroprotective agent by halting inflammation-induced brain damage. It might enhance endothelial performance and safeguard an endothelial cell line. However, additional study is required to completely comprehend the advantages and potential negative consequences of 7,8-DHF.


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