In the realm of scientific exploration, new compounds continually emerge, offering exciting possibilities for research and discovery. Among these is ACTH 1-39, a compound that has captured the attention of researchers worldwide. This enigmatic substance holds tremendous promise for uncovering groundbreaking insights in various fields. Let’s delve into the scientific definition, discovery, and potential applications, mechanisms, and potential side effects of ACTH 1-39, a compound poised to revolutionize scientific inquiry.

What is ACTH 1-39?

ACTH 1-39, scientifically known as adrenocorticotropic hormone ACTH 1-39, is a research compound characterized by its unique composition and properties. Derived from the larger adrenocorticotropic hormone (ACTH), this specific fragment represents a truncated version that retains key functional elements. Through meticulous research and experimentation, scientists have isolated Acth 1 39 and recognized its potential to unlock new avenues of scientific understanding. ACTH 1-39 stimulates the production of cortisol, muscle cells, metabolic syndrome, and the HPA stress axis. (R) (R) (R)

A neuroendocrine system called the HPA (hypothalamic-pituitary-adrenal) stress axis controls how the body reacts to stress. The hypothalamus, pituitary, and adrenal glands are all involved. The axis responds to stress by releasing hormones like CRH and ACTH, which trigger the synthesis of cortisol. The immune system, metabolism, and stress management are all impacted by cortisol. Conditions that affect health can be impacted by HPA axis dysregulation. Understanding this system potentially aids in managing diseases brought on by stress. Its intricacies and impacts on general well-being are now being studied and these interactions influence stress response, inflammation, metabolism, and overall health. Studying these connections helps us understand and address conditions related to stress. (R)

The Discovery of ACTH 1-39

The discovery of ACTH 1-39 traces back to extensive studies conducted in the field of endocrinology. Researchers investigating the intricate workings of the adrenal glands stumbled upon this remarkable compound during their exploration of ACTH. However, the research compound and its history and use are subject to ongoing investigation and ethical considerations.

Given the compound’s unique properties, researchers became captivated by its potential applications. ACTH 1-39 with a molecular mass of 4541 g/mol has shown potential in stimulating adrenal function and regulating corticosteroid production. This finding has garnered attention from various scientific disciplines, including neuroscience, immunology, and metabolism.

let’s highlight that ACTH 1-39 is not approved for therapeutic use or consumption without proper authorization from relevant regulatory bodies. Its current status is limited to research purposes only. Usage of the compound for research purposes must adhere to ethical guidelines governing the responsible exploration of novel substances. (R)

Potential Benefits of ACTH 1-39

ACTH 1-39, a research compound derived from adrenocorticotropic hormone, has garnered significant attention due to its potential benefits across various scientific disciplines.

Neurological Benefits

In a groundbreaking study published in the Journal of Neuroscience, researchers investigated the impact of ACTH 1-39 on neuronal plasticity. The results revealed that ACTH 1-39 administration promoted enhanced synaptic plasticity and neuronal resilience, suggesting its potential for cognitive enhancement and neuroprotective effects. (R)

Immunomodulatory Effects

Research published in the Journal of Immunology explored ACTH 1-39’s role in modulating immune responses. The study found that ACTH 1-39 treatment significantly reduced inflammation-related insults and regulated immune cell activation. These findings highlight the compound’s potential as a therapeutic agent in immunological disorders, including autoimmune diseases. (R)

Metabolic Regulation

A comprehensive study published in the journal Diabetes investigated ACTH 1-39’s effects on glucose homeostasis and insulin sensitivity. The researchers demonstrated that ACTH 1-39 administration potentially improved glucose tolerance, increased insulin sensitivity, and enhanced pancreatic beta-cell function. These results suggest that ACTH 1-39 may hold promise in the development of novel therapies for metabolic disorders, such as type 2 diabetes. (R)

Anti-inflammatory Properties

Researchers investigated ACTH 1-39’s potential as an anti-inflammatory drug in an animal study that was published in the Journal of Inflammation. The results showed that treatment with ACTH 1-39 greatly decreased the production of pro-inflammatory cytokines and alleviated tissue damage in an experimental model of inflammation. These findings suggest that the substance could prove to be a useful tool in the creation of anti-inflammatory tactics. (R)

Disclaimer: Although these trials show that ACTH 1-39 may have some advantages, more investigations are necessary to completely comprehend its mechanisms of action and possible uses. The substance should not be used without proper license and direction from competent specialists since it is presently only allowed for research usage. The investigation should be carried out according to legal requirements and ethical standards.

Key Features

Product Type: ACTH 1-39 5mg Powder
Purity: 98%
Applications: synthetic derivative of the vinca alkaloid vincamine
Variants: Available in Powder (5g)

CAS Number: 12279-41-3
Molecular Weight: 4541 g/mol
Chemical Formula: C207H308N56O58S
IUPAC Name: 4-[2-[[2-[[2-[[2-[[2-[2-[[2-[[4-amino-2-[[1-[2-[[2-[[6-amino-2-[[2-[[1-[2-
-2-yl]amino]-1-oxopropan-2-yl]amino]-5-oxopentanoic acid
Also known by Synonym: ACTH; corticotropin (R)

How Does ACTH 1-39 Work?

The specific mechanisms of ACTH 1 -39, a research compound derived from adrenocorticotropic hormone, are still being actively investigated. While the precise details are yet to be fully understood, existing research has provided insights into the potential mechanisms through which ACTH 1-39 may exert its effects:

Receptor Interactions

ACTH 1-39 is thought to interact with specific receptors present in cells throughout the body. By binding to these receptors, ACTH 1-39 may trigger downstream signaling pathways that mediate its various effects. ACTH 1-39 acts on endogenous melanocortin receptors agonist which is also present in the central nervous system. Melanocortin receptor is present in various cells, including muscle cells and when ACTH 1-39 binds to melanocortin receptors, it triggers a series of potential cellular responses working their activation and resulting in the release of corticosteroids and androgenic steroids. Its involvement in the dysregulation of metabolic syndrome and its impact on the HPA stress axis has also been identified as significant. (R)

Signaling Pathways

ACTH 1-39 likely modulates intracellular signaling pathways involved in cellular responses. These pathways may influence gene expression, protein synthesis, and other cellular processes, leading to the observed effects of ACTH 1-39. (R)

Neurotransmitter Modulation

In the context of neurological effects, ACTH 1-39 may modulate the activity of neurotransmitters in the brain. By influencing the release, reuptake, or receptor interactions of these chemical messengers, ACTH 1-39 could impact neuronal function and plasticity. (R)

Immune Cell Regulation

ACTH 1-39 is believed to regulate immune cell activity and function. It may modulate the activation and proliferation of immune cells, such as T cells and macrophages, and influence the production of cytokines and other immune-related molecules. In terms of immune cells, ACTH 1-39 also has demonstrated immunomodulatory properties. It may affect the activation and function of immune cells, such as T cells and macrophages. By regulating immune responses, ACTH 1-39 has the potential to modulate inflammation and immune-related conditions. (R)

Metabolic Pathways

ACTH 1-39 is thought to interact with metabolic pathways involved in glucose homeostasis, insulin sensitivity, and lipid metabolism. It may influence cellular glucose uptake, insulin secretion, and other metabolic processes through direct or indirect mechanisms. ACTH 1-39 has shown potential effects on metabolic regulation. It may influence glucose homeostasis, insulin sensitivity, and pancreatic beta-cell function. This compound’s interactions with metabolic pathways could have implications for conditions related to metabolic syndromes, such as obesity, insulin resistance, and dyslipidemia. (R)

Interaction with Adrenal Cortex

ACTH 1-39 may have interactions with the adrenal cortex. The adrenal cortex stimulation, as a part of the adrenal glands, plays a crucial role in producing various hormones, including cortisol. Research suggests that ACTH 1-39 could potentially influence the production and regulation of cortisol, which is involved in stress response, inflammation, and metabolism. (R)

Precautions to Consider

When considering ACTH 1-39, it’s essential to be aware of certain precautions. Here are some important points to keep in mind:

  • Follow Instructions: Read and follow the provided instructions or any accompanying documentation.
  • Research Purposes: Recognize that the compound is only for laboratory research and should not be used for self-administration or other non-research reasons.
  • Expert Guidance: Seek advice from experienced researchers, scientists, or medical experts in the field. Their knowledge may assist in ensuring optimal application, dosage, and safety measures.
  • Regulatory Compliance: Search for regulatory compliance such as the Food and Drug Administration (FDA) that may apply to the usage of the compound.
  • Handling and Storage: To preserve the safety and integrity of the compound, observe correct handling practices and store it in a cool, dry place to maintain its stability and prevent degradation.
  • Safety and Disposal: Keep the compound out of reach of children to prevent accidental ingestion or exposure, and follow recommended disposal methods.

ACTH 1-39 is not approved for therapeutic use or consumption by regulatory authorities. Its current status is limited to research purposes only. The approval process for any substance varies by country and regulatory body, and it is essential to consult with the appropriate authorities and adhere to legal and ethical guidelines before considering the use of ACTH 1-39 for any purpose.

Potential Side Effects of ACTH 1-39

While the potential side effects of ACTH 1-39 are still being investigated, it is important to be aware of possible adverse reactions. As a research compound, ACTH 1-39 may have unknown risks and side effects. Commonly reported adverse reactions may include gastrointestinal disturbances, allergic reactions, changes in blood pressure, hormonal imbalances, and alterations in immune system function. (R)


ACTH 1 -39 is a research compound derived from the adrenocorticotropic hormone that holds significant promise in various scientific fields. While its precise mechanisms of action are still being investigated, ACTH 1-39 has shown potential benefits such as neuroprotective effects, immunomodulatory properties, metabolic regulation, and anti-inflammatory actions. However, further research is needed to fully understand its effects, and the use of ACTH 1-39 should be approached with caution. Compliance with ethical guidelines and regulatory protocols is essential to ensure the responsible exploration of ACTH 1-39’s potential and prioritize safety.

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