Alpha-glycerylphosphorylcholine (αGPC) is a compound derived from phosphatidylcholine. It acts as a precursor to acetylcholine, a neurotransmitter that plays a crucial role in the functioning of the nervous system. [R] Alpha-GPC is the most bioavailable form of choline known for its potential effects on cognitive health, particularly in relation to diseases like Alzheimer’s. While it is important to note that this article does not promote the sale of Alpha-GPC for human use, we will explore some of the research findings that suggest its potential benefits for memory and attention.
In addition to its potential benefits for Alzheimer’s patients, other studies have explored the broader cognitive-enhancing properties of Alpha-GPC. While it is important to approach these findings with caution, as they are still being researched, some references suggest that Alpha-GPC could potentially improve memory and attention in individuals without cognitive impairments.
In the next section, we will delve into some of the specific studies and findings related to Alpha-GPC’s effects on cognitive health, particularly in relation to Alzheimer’s disease and its potential role in improving memory and attention.
RCD.Bio offers Alpha-GPC Powder with the following specifications:
- A purity of 99.97%, was verified by first and third-party laboratory testing.
- Available in 15g powder
How does Alpha GPC 50 Work?
Alpha-GPC, a compound known for its potential cognitive benefits, operates by enhancing the synthesis and release of acetylcholine in the brain. Acetylcholine is a crucial neurotransmitter involved in many cognitive processes. When Alpha-GPC is consumed in research, it undergoes a conversion process into phosphatidylcholine, which is the active form of choline in the body. [R] [R] Choline is a water-soluble nutrient, this converted compound then travels to cholinergic synaptic terminals, where it stimulates the production and release of acetylcholine, ultimately influencing cognitive processes. Acetylcholine plays an important role in memory, learning, and attention.
In addition to its impact on acetylcholine, Alpha-GPC may also have other effects on the brain. It has been suggested that Alpha-GPC can increase the levels of gamma-aminobutyric acid (GABA), the primary inhibitory neurotransmitter in the central nervous system. GABA helps regulate the body’s response to anxiety, stress, and fear. By increasing GABA levels, Alpha-GPC may contribute to a sense of calmness and relaxation. [R][R]
Furthermore, Alpha-GPC has been found to potentially increase dopamine synthesis in the brain. Dopamine is a neurotransmitter associated with motivation, pleasure, and reward. In lab-tested rats, the administration of Alpha-GPC resulted in elevated dopamine levels in specific brain regions. Interestingly, another compound called CDP-choline, which was also examined in the study, did not exhibit the same effect on dopamine levels. [R]
Alpha-GPC might also influence serotonin activity in brain health. Serotonin is a neurotransmitter that regulates mood, sleep, digestion, and various body functions. The aforementioned study revealed that administered Alpha-GPC may increase serotonergic activity in certain brain areas, such as the frontal cortex and striatum.
Additionally, there is evidence suggesting that Alpha-GPC could potentially boost the release of human growth hormone (HGH). HGH is an essential hormone involved in growth, metabolism, and cellular repair. Studies have reported that Alpha-GPC administration may enhance HGH secretion in both young and elderly individuals, providing promising prospects for further research in this area. [R][R]
The scientific basis behind the benefits of Alpha-GPC
Alpha-GPC has been the subject of research using both human and animal models. The important findings include the following:
Various preclinical studies have also been conducted to investigate the nootropic and neuroprotective effects of Alpha-GPC. These studies found that α-GPC could potentially reduce cognitive decline caused by brain injury, lack of blood supply to the brain, and seizures. [R][R][R]
Cognitive Function in Epilepsy
A groundbreaking study has explored the potential of α-GPC, a choline compound found in the brain and known as an acetylcholine precursor, in possibly improving cognitive function in test subjects with epilepsy. When α-GPC was administered to rats starting from three weeks after the seizure, a significant improvement in cognitive function was observed. This improvement can be attributed to several factors. Firstly, α-GPC demonstrated its ability to reduce neuronal death, which is crucial for maintaining brain health and function. Secondly, it showed promising effects in diminishing the disruption of the blood-brain barrier (BBB), a protective layer that separates the brain from circulating blood. Preserving the integrity of the BBB is essential for preventing harmful substances from entering the brain. Lastly, α-GPC was found to possibly promote neurogenesis, the formation of new neurons in the brain, which is vital for cognitive processes. Further research is needed to validate these findings and explore the full scope of α-GPC’s benefits in epilepsy treatment.
A systematic review of over 20 clinical studies examined the effects of α-GPC. In all of these studies, treatment with Alpha-GPC improved deficits in memory and attention. Some studies have also demonstrated possible beneficial effects on emotional and physical symptoms (fatigue, dizziness). [R]
Also, recent studies have shown that α-GPC may have beneficial effects on cognitive function. The compound also showed a good safety profile and was well tolerated. The authors of this study suggested that the potential cognitive abilities of α-GPC need further investigation. [R]
α-GPC shows great potential as a therapeutic for AD.
In a double-blind, randomized, placebo-controlled study, test subjects with mild to moderate Alzheimer’s disease were treated with α-GPC or placebo. The study lasted 180 days. At the end of the study, the alpha GPC treatment group showed potential improvement in all AD symptoms. [R]
Another study compared the effects of alpha-GPC plus other supplements such as donepezil versus donepezil plus placebo in test subjects with Alzheimer’s disease. Findings suggest that α-GPC may enhance the efficacy of donepezil, a cholinergic therapy already used to possibly treat AD. [R]
A clinical study investigated the effects of two doses of her Alpha-GPC on physical performance in healthy test subjects. 600 mg alpha GPC administration showed promising potential to significantly improve running speed, reaction time, and traction in the treatment group. [R]
In another study, 13 male test subjects were given either 600 mg daily of α-GPC or a placebo. This process lasted only 6 days. A final test revealed that the alpha GPC group may have had better lower body strength than members of the placebo group. [R]
Two of her other studies reveal the effects of α-GPC administration on performance. In the first study, treatment with 200 mg alpha-GPC could improve vertical bounce by 8.5%. A 14% increase in bench press strength could have been observed after administration of 600 mg alpha-GPC in the second step. [R][R]
Three uncontrolled studies examined the possible effects of alpha-GPC treatment on stroke test subjects. In these studies, treatment with α-GPC resulted in acute recovery of cognition, function, and movement, demonstrating the potential of α-GPC as a potential stroke recovery therapy. [R]
Another study evaluated the effects of administering alpha-GPC to 2,044 test subjects who had recently suffered a stroke or transient ischemic attack (TIA). The results of the study support a potential therapeutic role and excellent tolerability of α-GPC in test subjects with acute stroke or (TIA). [R]
In a double-blind, placebo-controlled study, eight healthy male test subjects ingested one dose of her Alpha-GPC capsules or a placebo. The results of the study showed potentially significant hepatic fat oxidation and concomitant increases in choline levels in the GPC group. [R]
Eye ischemic syndrome
Ocular(Eye) ischemia syndrome is a rare but sight-threatening condition, is a rare condition characterized by reduced blood flow to the eye and surrounding structures.
A study of 51 test subjects with this condition found that adding α-GPC to standard care improved blood flow to the eye, sharpened vision, and may have accelerated retinal repair. [R]
The use of alpha-GPC as a new dietary supplement designed to improve memory has been approved by the FDA. Alpha-GPC is considered a prescription drug by qualified health physicians in various European nations.
Despite this, this material is being provided for educational reasons only; it is not intended to be taken as medical advice for suspected medical conditions. Alpha-GPC is not meant for human consumption and is only meant for use in laboratories and research.
Potential side effects
Alpha-GPC was deemed safe in each of the aforementioned clinical trials. However, a small percentage of test subjects did have minor side effects after a few weeks. These negative side effects might have included indigestion, motion sickness, headaches, and agitation. [R][R][R]
Where Can I Buy the Best Alpha-GPC Powder?
RCD.bio offers Alpha-GPC for laboratory research use only.
When buying Alpha-GPC, it is important to choose a reputable seller who provides quality products. At RCD.bio, each product is accompanied by a third-party-issued Certificate of Analysis showing the identification, purity, and concentration of our product.
RDC. Bio also offers Alpha-GPC 50% in 30g powder
Both forms of Alpha-GPC can be utilized in various experimental settings, but the choice between them depends on the specific requirements of the research. The Alpha-GPC Powder >99.97% offers a higher purity and concentration, making it suitable for experiments that demand precise and concentrated Alpha-GPC dosage. Conversely, Alpha-GPC Powder 50% provides a slightly lower concentration, which may be more suitable for experiments requiring a milder or moderate dosage of Alpha-GPC or when it is used in combination with other substances.
Alpha-glycerylphosphorylcholine (αGPC) is a deacylated phosphatidylcholine derivative that is an acetylcholine precursor, increasing the amount of acetylcholine in the brain. It may also increase GABA, dopamine, and serotonin levels and the release of human growth hormone. Alpha-GPC shows potential therapeutic benefits for cognitive diseases such as Alzheimer’s and cognitive decline, as well as stroke recovery and ocular ischemia syndrome.
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