Introduction
One of the main cannabinoids present in the majority of Cannabis species is CBG or Cannabigerol.[R] In fact, this is one of the more than 120 cannabinoid chemicals found in the Cannabis plant. [R] Due to its tendency to occur in lower amounts than more well-known cannabinoids like THC (tetrahydrocannabinol) and CBD (cannabidiol), CBG is regarded as a minor cannabinoid. CBG is attracting interest due to its unique interactions with the endocannabinoid system and potential therapeutic benefits. Furthermore, it interacts with the endocannabinoid system, which has the potential treatment for mood regulation, hunger stimulation, memory improvement, and pain relief. [R]
According to research, CBG may potentially lower intraocular pressure and may have anti-inflammatory, antioxidant, and anti-tumor properties, as well as anti-anxiety, neuroprotective, dermatological, and appetite-stimulating/suppressing properties.
Key Features of Cannabigerol
RCD.Bio offers CBG isolate with the following specifications:
- A purity of 98%, verified by third-party laboratory testing.
Cannabigerol [R]
- CAS Number: 25654-31-3
- Molecular weight: 316.5 g/mol
- Chemical Formula: C21H32O2
- Synonyms: Cannabigerol (CBG)
- IUPAC Name: 2-[(2E)-3,7-dimethylocta-2,6-dienyl]-5-pentylbenzene-1,3-diol
How It Works
CBG has the potential to behave as an agonist or antagonist at cannabinoid receptors. A receptor is activated by an agonist, whereas it is blocked by an antagonist. The variable agonist or antagonist properties of CBG may account for some of its varied effects.
CBG interacts with the CB1 and CB2 receptors, which are the two main receptor subtypes found in the endocannabinoid system (ECS). These receptors can be found all over the body, although CB1 receptors are more prevalent in the central nervous system while CB2 receptors are more prevalent in the immune system and peripheral tissues.
The brain and central nervous system contain the majority of the CB1 receptors, which CBG can bind to. Functions like pain perception, mood, and appetite can be affected by the activation of CB1 receptors.
CBG may also bind to CB2 receptors, which are mostly present in peripheral tissues and immunological cells. The immune system’s reaction and inflammation can be affected by CB2 receptor activation.
Furthermore, CBG may interact with other receptor systems in the body, including the serotonin receptor (5-HT1A), which could contribute to its possible mood-regulating effects. [R] [R] [R]
CBG Research
Numerous studies have been conducted on the potential application of CBG. Below are some of the relevant findings on CBG benefits :
CBG as Anti-Inflammatory
One systematic review concludes that there is substantial preclinical evidence demonstrating the anti-inflammatory effects of cannabinoid drugs in gut inflammation. However, the review emphasizes the need for larger randomized controlled trials (clinical studies) to further investigate the potential therapeutic benefits of cannabinoids in test subject’s intestinal inflammation.[R]
The effects of CBG were investigated in the chronic relapsing inflammatory diseases Crohn’s disease (CD) and ulcerative colitis are included under inflammatory bowel disease (IBD) wherein mice with experimental colitis brought on by intracolonic dinitrobenzene sulphonic acid (DNBS), CBG has potential which suppresses the immune system without affecting T cell activity. As a result, the study reveals that FTY720 may be a beneficial therapeutic choice for those who have IBD (inflammatory bowel disease). [R]
Furthermore, CBG administration lessen experimental colitis by decreasing nitric oxide generation in macrophages via CB2R activation and decreasing reactive oxygen species (ROS) in intestinal epithelial cells as shown in another study. [R]
CBG on Pain relief
CBG may have analgesic (pain-relieving) properties, making it a potential candidate for the treatment of various types of pain. [R]
Cannabigerol as Anti-anxiety
In vitro and in vivo investigations have shown that CBG has a 5-HT1A antagonistic effect. Because of this, it has been suggested that it may have anti-anxiety properties. [R] [R]
Cannabigerol as Neuroprotective
In tests replicating oxidative stress and neurotoxicity as they occur in neurological diseases in rats, the neuroprotective effects of CBG and CBD were compared. In astrocytes exposed to hydrogen peroxide, CBG, and CBD exhibit antioxidant activity and increase the amount of serotonin in the cortex. [R]
CBG has shown effects in protecting and preserving brain cells, which could be relevant for conditions for neurodegenerative disorders. Particularly, a study focused on cannabigerol (CBG) and its ability to protect NSC-34 motor neurons from toxicity induced by the medium of LPS-stimulated macrophages and showed promising results. [R] Several studies for neuroprotective effects on different test subjects have been also noted to test CBG’s neuroprotective effects. [R]
CBG as Antibacterial
CBG has demonstrated antibacterial properties and may be effective against bacterial infections. The most frequent pathogen linked to tooth caries is Streptococcus mutans (S. mutans), a gram-positive, facultatively anaerobic bacteria. CBG has antibacterial action against S. mutans. [R]
In another study, cannabidiol (CBD) and cannabigerol (CBG), were studied for their antibacterial characteristics, specifically their capacity to inhibit and eliminate bacterial biofilms, inhibition of Pseudomonas aeruginosa and Escherichia coli. Also, the adherence of Staphylococci bacteria to keratinocytes (skin cells) was found to be inhibited by CBD and CBG. [R]
Cannabigerol on Appetite Stimulation / Suppression
Some research suggests that CBG may stimulate appetite, which could be beneficial for individuals with appetite loss or eating disorders. [R]
This has also been noted to have weight loss potential. [R] In another study using adult female mice, CBG compound has the potential for development as an anti-obesity drug. [R]
Cannabigerol on Glaucoma Treatment
A serious eye disorder called glaucoma can cause permanent blindness because it raises intraocular pressure (IOP) and harms the optic nerve. CBG may help reduce intraocular pressure and has been investigated as a potential treatment for glaucoma. [R]
CBG on Cancer /Tumor
Studies demonstrate that CBG possesses antitumoral properties, as it effectively inhibits the growth of skin melanoma cells and mouth epidermal carcinoma cells in in vitro experiments. [R]
In the human MDA-MB-231 cell line, CBG was proven to be effective against breast cancer. [R]
In another study, CBG inhibited the growth of colon tumors and xenograft malignancies brought on by chemicals. CBG suppressed CRC cell growth and slowed tumor growth in the same experimental condition. [R]
In the aggressive brain cancer glioblastoma, a study discovered that CBG slows the growth of this tumor and prevents the invasion of glioblastoma cells. Additionally, CBG is beneficial in lowering glioblastoma stem cells that are resistant to therapy. These results suggest that CBG, which has analgesic, anti-nausea, and appetite-stimulating properties, maybe a potential adjuvant treatment for glioblastoma. [R]
CBG and Psoriasis
In a study, results demonstrate that cannabis reduces keratinocyte proliferation, supporting their potential use in the management of psoriasis. [R]
CBG and Nausea
In a study in rats and shrews, it was determined how cannabidiol (CBD) and cannabigerol (CBG), two non-psychotropic cannabinoids that have been reported to behave as 5-hydroxytryptamine 1A (5-HT(1A)) agonist and antagonist, respectively, interacted. Hence, in the control of nausea and vomiting, interactions between modest dosages of CBG and CBD may work against one another at the 5-HT(1A) receptor. [R]
It’s important to note that research on CBG is still in its early stages, and more studies are needed to fully understand its effects and potential medical applications. Additionally, the legal status of CBG varies by location, so it’s essential to be aware of local laws and cbg legal regulations regarding its use and distribution. Always consult with a healthcare professional before using CBG or any cannabis-related product for medicinal purposes.
Precautions
The information presented here is for educational purposes only and should not be construed as medical advice. CBG is intended for laboratory research use only and is not intended for humans.
Potential Side Effects
Cannabigerol’s safety and potential negative effects are not known with sufficient certainty due to the lack of credible information. [R]
Where Can I Buy CBG Online?
RCD.bio offers CBG for laboratory and research use only.
When buying CBG, it is important to choose a reputable market seller who provides quality CBG. At RCD.bio, customers can ensure each product is accompanied by a third-party-issued Certificate of Analysis showing the identification, purity, and concentration of our product. RCD also offers other nonpsychoactive cannabinoids and other cbg products such as cbg oil massage, full spectrum cbg oil, cbd oil, cbg isolate. Others also offer s cbg gummies, cbg cannabinoid, cbg oils and stem cell cannabinoid.
Conclusion
CBG is a minor cannabinoid found in Cannabis sativa(hemp plant), with over 120 cannabinoids identified in the hemp plants. It interacts with the endocannabinoid system, which plays a role in mood regulation, appetite stimulation, memory improvement, and pain relief.
CBG may act as either an agonist (activator) or antagonist (blocker) at cannabinoid receptors. It interacts with CB1 and CB2 receptors, which are present throughout the body, affecting processes like pain perception, mood, and immune response. CBG may also interact with other receptor systems, including the serotonin receptor (5-HT1A), potentially contributing to mood regulation.
Several studies have been published as to CBG’s potential. It includes anti-inflammatory, wherein CBG has shown anti-inflammatory effects, particularly in gut inflammation, making it a potential therapeutic option for conditions like Crohn’s disease and ulcerative colitis. Another is pain relief, CBG may have analgesic properties, suggesting it could be used to treat various types of pain; anti-Anxiety, neuroprotective, antibacterial, appetite stimulation/suppression: CBG may stimulate appetite, making it useful for appetite loss or weight management, glaucoma treatment. It has been seen to have potential effects in inhibiting the growth of various cancer cells, including skin melanoma, mouth epidermal carcinoma, breast cancer, colon tumors, and glioblastoma (brain cancer).
CBG has been found to help manage psoriasis by reducing keratinocyte proliferation. Lastly, it may have benefits as anti-nausea.
It’s important to note that CBG research is still evolving, and more studies are needed to fully understand its mechanisms of action and potential medical applications. Additionally, the legal status of CBG varies by region, so it’s essential to be aware of local regulations.
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