Citicoline (CDP-choline) is a popular nootropic compound known for its potential to convert into choline and cytidine when ingested. Unlike regular choline, which is primarily produced in the liver, citicoline has a more intricate structure. It is important to note that citicoline is distinct from alpha-GPC, another cholinergic compound that is naturally synthesized in the brain.

Submitted clinical studies have demonstrated that Citicoline holds promise in enhancing memory and behavior, particularly in individuals with mild to moderate cognitive impairment. Beyond its cognitive benefits, this nootropic has also shown the potential to improve reaction speed, mental clarity, and overall cognition. Furthermore, there is evidence to suggest that citicoline may possess neuroprotective properties, making it a possible option for supporting brain health.

Even though the data we have for citicoline CDP choline sodium seems to be promising, more research studies for publication are still needed. We sell this nootropic product for research purposes only.

Citicoline CDP Choline Sodium Product Details

Citicoline, also known as CDP-choline, is an endogenous research compound naturally produced by the body. To avoid confusion, scientists refer to the substance as “CDP-choline” when it is produced within the body and as “Citicholine” when it is administered as a research compound. This nomenclature ensures clarity in scientific discussions.

When Citicholine is ingested, it undergoes a conversion process that results in the formation of two compounds: cytidine and choline. These compounds have the ability to cross the blood-brain barrier and enter the brain, where they can potentially contribute to the resynthesis of CDP-choline within brain cells. CDP-choline, in turn, plays a crucial role in the production of phospholipids, essential components of cell membranes.

Numerous clinical studies have highlighted the potential nootropic, neuroprotective, and eyesight-enhancing properties of Citicoline. In particular, research suggests that it may have positive effects on mental performance and cerebral blood flow, potentially benefiting individuals with Alzheimer’s disease (AD). The results of these studies indicate that Citicoline holds promise as a therapeutic agent for AD.

Key Features of Citicoline CDP Choline Sodium

  • 98% Purity
  • 10g
  • Sold for research purposes only

Potential Benefits of Citicoline CDP Choline Sodium

Citicoline and Stroke Recovery

Studies investigating the role of Citicoline in stroke recovery have shown promising results. A meta-analysis of four clinical trials involving 1,372 test subjects found that early administration of Citicoline (2,000 mg) within 24 hours of stroke potentially increased the chances of complete recovery by 38%. [R]

Another compound surveillance study supported these findings, showing potential improvements in neurological, functional, and global outcomes without significant safety concerns. A systematic review of clinical trials further confirmed the potential benefits of Citicoline administration in acute ischemic stroke, either as a standalone treatment or in combination with other therapies. [R] [R]

Citicoline and Nootropic Effects

Research on healthy test subjects has explored the nootropic effects of Citicoline. One study focusing on healthy males found that the administration of Cognizin Citicoline, a dietary supplement, potentially improved attention and reduced impulsivity compared to a placebo. Additionally, clinical trials involving Citicoline-Caffeine beverages demonstrated potential improvements in concentration, working memory, sustained attention, and mental alertness. [R][R][R]

Notably, a pilot study conducted on marijuana smokers revealed that Citicoline administration potentially improved cognition, reduced impulsive reactions, and increased motivation to quit smoking. [R]

Citicoline and Cognitive Enhancement

Extensive clinical research has been conducted to explore the cognitive enhancement potential of Citicoline. A review of 14 clinical trials focused on test subjects with mild to moderate cognitive impairment, predominantly over the age of 60. The findings revealed that Citicoline could potentially improve behavior and memory function in this population. Additionally, a separate trial involving 2,817 test subjects with cognitive impairment showed that Citicoline treatment potentially eliminated depression, memory shortage, and insomnia in a significant percentage of participants. [R][R]

Furthermore, studies investigating the effects of Citicoline on laboratory subjects with poor brain circulation and dementia found significant improvements in behavior, memory function, and reaction speed, with higher dosages of Citicoline (2,000 mg) showing better results. [R][R][R]

Citicoline and Lazy Eye

Citicoline treatment has shown promise in improving the efficacy of standard treatments for lazy eyes (amblyopia). Several randomized clinical trials involving children have reported potential improvements in vision when Citicoline was administered alongside eye patching, the standard treatment for lazy eyes. Moreover, a separate trial involving adults with lazy eyes demonstrated potential vision improvement and optic nerve healing following CDP-choline administration. [R][R][R][R][R]

Citicoline and Alzheimer’s Disease

Clinical trials focusing on Alzheimer’s disease (AD) have explored the effects of Citicoline treatment. In one trial, Citicoline potentially improved mental performance and reduced pro-inflammatory cytokine levels in patients with AD. Another study demonstrated the safety and efficacy of Citicoline treatment in AD patients, potentially improving cognitive performance, cerebral blood perfusion, and brain bio-electrical activity. [R][R]

A third trial reported potential improvements in mental performance and stabilized immune function in AD patients after three months of Citicoline treatment. [R]

Citicoline and Optic Neuropathy

Optic neuropathy, characterized by impaired blood flow to the optic nerve and sudden vision loss, has been the focus of clinical trials investigating Citicoline treatment. In one randomized trial involving clinical models with optic neuropathy, Citicoline potentially led to sharpened vision and reduced nerve damage after at least six months of treatment. Importantly, these potential improvements persisted even after discontinuing Citicoline treatment. [R][R]

Citicoline and Glaucoma

Glaucoma, a leading cause of blindness in test subjects over 60, has been investigated in relation to Citicoline treatment. Clinical trials have shown potential benefits of Citicoline in glaucoma patients, including nerve damage repair and improved eyesight. Additionally, Citicoline has demonstrated the potential to slow down the rate of disease progression, suggesting neuroprotective effects in glaucomatous conditions. [R][R][R]

How It Works

Citicoline has been the subject of research indicating its potential to balance neurotransmitters and provide protection against age-related and oxidative damage to the nervous system. One way in which Citicoline achieves these effects is by potentially boosting neurotransmitter production in the brain. This can contribute to improved communication between nerve cells and overall brain function. Additionally, Citicoline may stimulate mitochondria, the cellular powerhouses, to produce more energy, supporting optimal brain performance.

Furthermore, Citicoline has been found to potentially inhibit the inflammatory enzyme phospholipase A2. By doing so, it may help reduce inflammation in the brain, which is associated with various neurological conditions. Another significant effect of Citicoline is its potential to increase the activity of the master antioxidant glutathione. This antioxidant plays a crucial role in neutralizing harmful free radicals and protecting brain cells from oxidative damage.

In addition to these benefits, Citicoline may also play a role in preserving phosphatidylcholine, a vital component of the grey matter in brain tissue. Phosphatidylcholine, along with sphingomyelin, has the potential to support the construction of myelin, a protective layer that surrounds nerve cells, safeguarding them from damage and facilitating proper nerve signal transmission.


When researching the use of Citicoline CDP Choline Sodium, it is essential to take certain precautions. Here are some precautions to keep in mind:

Observe best practices for studying research chemicals: Studying research chemicals requires a responsible and informed approach to ensure safety and meaningful scientific exploration. Research chemicals, also known as designer drugs or experimental compounds, are substances synthesized for scientific investigation or exploration of their properties.

Follow recommended dosage: Adhere to the recommended dosage instructions outlined on the product label. Avoid exceeding the suggested dose to minimize the risk of potential adverse effects among test subjects.

Safety and Side Effects

Citicoline CDP Choline Sodium is generally considered safe for most test subjects when used appropriately. Clinical trials and research have shown a favorable safety profile for Citicoline, with few reported adverse events. Commonly reported side effects include mild gastrointestinal disturbances, nausea, diarrhea, and stomach discomfort, although these are typically rare and transient.


In conclusion, Citicoline CDP Choline Sodium has demonstrated numerous benefits in various areas of cognitive health and neurological conditions. This compound, also known as citicoline sodium or cytidine 5 diphosphocholine, plays a crucial role in supporting the integrity of cell membranes and enhancing brain function. The use of Citicoline CDP Choline Sodium has shown potential in improving cognitive performance, reducing brain fog, and enhancing focus.

Studies have highlighted the ability of Citicoline CDP Choline Sodium to support the synthesis of essential phospholipids, which protect the brain and promote optimal brain function. Its neuroprotective properties have been observed in conditions such as cognitive impairment, stroke recovery, and glaucoma.

It is important to note that while the alleged benefits of Citicoline CDP Choline Sodium are encouraging, the quality and purity of the product are vital. When considering the purchase of any research compounds, it is crucial to ensure that the product meets the necessary quality standards and is from a reputable source.

In the field of cognitive enhancement and neurological support, continued research and exploration of Citicoline CDP Choline Sodium are essential to learning more about its potential applications and efficacy.

In summary, Citicoline CDP Choline Sodium acts as a valuable chemical compound for researchers seeking to improve cognitive function, focus, and overall brain health. Its presence in the market provides an example of a potential aid for those investigating research chemicals that could support cognitive abilities.


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