In the realm of cognitive enhancers, a remarkable synthetic substance from the racetam family has emerged: Coluracetam[R]. The renowned Mitsubishi Tanabe Pharma Corporation first created and investigated this special substance for its potential to treat malfunctioning acetylcholine systems in Alzheimer’s disease. [R] Since then, both preclinical and clinical research have focused on it. [R] While its primary applications lie in the realm of cognitive impairment such as depression and generalized anxiety disorder,[R] it is important to note that Coluracetam is strictly intended for research purposes and should not be used by humans. In this article, we will go deeper into the intriguing world of Coluracetam in this article, learning about its history, possible uses, and position as a research chemical.

Key Features

RCD.Bio offers Coluracetam with the following specifications:

  • A purity of 98%, verified by first and third-party laboratory testing.
  • Available in tablet form: 30mg/27ct/810mg and 30mg/54ct/1.6g


  • CAS Number:            135463-81-9
  • Molar Mass:             341.411 g·mol−1
  • Chemical Formula: C19H23N3O3
  • IUPAC Name:           N-(2,3-Dimethyl-5,6,7,8-tetrahydrofuro[2,3-b]quinolin-4-yl)-2-(2-oxo-1-pyrrolidinyl)acetamide

How Coluracetam Works?

Coluracetam has demonstrated considerable results in high-affinity choline uptake, which is essential for the synthesis of acetylcholine, despite the fact that its particular mechanisms of action are not yet fully understood. Memory and learning are only a couple of the many cognitive processes that acetylcholine is essential for. Coluracetam increases choline absorption, addressing the primary constraint on acetylcholine synthesis, and potentially improving cognitive function. [R]

In addition to its choline uptake enhancer, coluracetam has been identified as an agonist of AMPA receptors. AMPA receptors play a crucial role in facilitating glutamatergic synaptic transmission and plasticity, which are needed for the molecular processes underlying memory and learning. By acting as an AMPA receptor agonist, coluracetam has the potential to further enhance cognitive functions [R][R]

Another notable aspect of coluracetam’s mechanism is its possibility to protect neurons from damage caused by cholinergic neurotoxins. This has been observed in animal models, suggesting a potential neuroprotective effect of coluracetam  [R]

The scientific basis behind the benefits of Coluracetam

The following claimed benefits are only partially supported by clinical research. Before coluracetam can be used for any of the following purposes, further evidence is required.


Coluracetam is an intriguing substance with possible neuroprotective effects in the field of brain health. Coluracetam may protect the brain from glutamate neurotoxicity induced brought on by ionomycin, a known factor in illnesses like Parkinson’s disease and other neurodegenerative disorders, according to the results of a preclinical study.[R]

Glutamate, a vital neurotransmitter in the brain cells, can become toxic in excessive amounts, leading to neuronal damage and dysfunction. Coluracetam, by acting as a potential shield, may help mitigate the harmful effects of glutamate neurotoxicity, offering hope for the possible prevention or management of neurodegenerative diseases.[R]

While these preliminary findings are intriguing, it is crucial to emphasize that further research is necessary to fully understand the extent of coluracetam’s neuroprotective capabilities. 


In the pursuit of a research study on depression, researchers have turned their attention to coluracetam, a compound with promising cognitive-enhancing properties. A clinical trial was conducted involving 101 test subjects who were not only experiencing depression but also grappling with anxiety. These individuals had previously tried two different antidepressants but without success. In the study, coluracetam was administered at doses of 80 mg three times a day. The results revealed a potential beneficial effect on depression, offering hope as an alternative option. However, it is important to note that further research is necessary to fully understand the extent of coluracetam’s efficacy in depression management.[R

It is worth mentioning that although phase 2a clinical trials on major anxiety and depression were conducted using coluracetam, the findings of those investigations were not made public, and the study of this substance in humans has been discontinued.

Effects on Learning and Memory

In the realm of cognitive enhancement, coluracetam emerges as a compound with intriguing effects on learning and memory. Through preclinical trials involving rats, coluracetam has demonstrated its potential to improve memory and learning in specific conditions.

In one preclinical trial, rats that had previously received treatment with a nerve toxin impairing choline uptake in the brain were given coluracetam. The results were promising, as coluracetam effectively enhanced memory and learning in these rats. Remarkably, these benefits persisted even after the therapy, highlighting the potential long-lasting effects of coluracetam. Importantly, these effects were not observed in rats that did not receive the nerve toxin, underscoring the specific conditions under which coluracetam may prove beneficial.[R]

Another rat experiment further found the cognitive potential of coluracetam. In this case, coluracetam therapy was found to repair the damage induced by PCP (phencyclidine) to the learning function. The experiment inhibits the enzyme choline acetyltransferase (ChAT), which plays a crucial role in acetylcholine synthesis. As it is a neurotransmitter acetylcholine is known for its involvement in learning and memory processes.[R][R]

Even though these results are intriguing, it’s essential to remember that more investigation is required to properly comprehend the precise mechanisms and potential effects of coluracetam on human learning and memory. 

Enhancing Cognitive Function

In the pursuit of enhancing cognitive function, coluracetam emerges as a compound with possible potential. Through a choline transport system involving rats with chemically compromised memory, coluracetam was administered repeatedly to explore its effects.

The study’s findings unveiled a fascinating discovery: Coluracetam had a notable impact on the choline transporter regulation system, leading to long-lasting cognitive improvements. By modulating this system, coluracetam seemed to positively influence cognitive function, offering promise for those seeking ways to enhance their mental capabilities.[R]


Coluracetam emerges as a drug with potential in the field of anxiety management. The possibility of coluracetam lowering anxiety levels has been investigated through a rat study.

The findings of the study reveal that coluracetam therapy led to a significant reduction in anxiety, amounting to a remarkable 20%. Notably, this reduction surpassed the effect observed with a single dose of a well-known drug, by 8%. These results highlight the potential efficacy of coluracetam in alleviating anxiety symptoms. [R]

It is significant to emphasize that even though these results are encouraging, more investigation is necessary to completely comprehend the mechanisms and potential uses of coluracetam in anxiety. Additionally, it is essential to stress that drugs like coluracetam offered by RCD Bio are solely created for research use and not for human use.


Coluracetam, is a possible drug that gives a glimpse of hope in the field of schizophrenia research. Coluracetam has been shown in investigations on nerve-damaged rats to improve the activity of choline acetyltransferase (ChAT), an enzyme that is impaired in people with schizophrenia.

The findings suggest that coluracetam may have the capacity to positively influence the neurochemical pathways imbalances associated with schizophrenia. However, it is crucial to emphasize that the current knowledge is based on animal studies, and the true benefits of coluracetam for schizophrenia remain uncertain without extensive, randomized clinical trials involving human participants.[R]

Eye Health

Coluracetam shows promise as a potential therapeutic approach for maintaining eye health. Animal rodent models have revealed the benefits of coluracetam in possibly preventing and treating retinal and optic nerve damage, as well as ischemic retinopathy.

The potential of coluracetam resides in its capacity to protect and promote healing in the delicate structures of the eye. Coluracetam’s neuroprotective characteristics may aid in preventing damage to the retina and optic nerve, which are critical for visual function. Furthermore, coluracetam has shown possible treatment of ischemic retinopathy, a disorder defined by insufficient blood supply to the retina. [R]


The information presented here is for educational purposes only and should not be construed as medical advice. Coluracetam is intended for laboratory research use only and is not intended for human consumption.

Potential side effects

Users mentioned the following negative effects: mental haze, major depressive disorder, higher depression, suicidal ideas and various outcomes based on the amount of sleep. [R]


Coluracetam is a synthetic nootropic compound from the racetam family. Its possible impacts on cognitive performance and neuroprotection have been investigated. The specific mechanism of action of coluracetam is unknown, however, it is thought to have high-affinity choline transporters, which are necessary for acetylcholine production. It has also been discovered to operate as an AMPA receptor agonist, which has the ability to influence memory and learning processes.

Some potential benefits of coluracetam that have been studied include neuroprotection against glutamate neurotoxicity, potential antidepressant effects, improvement in learning and memory, enhancement of cognitive function, reduction of anxiety, and potential benefits in eye health and schizophrenia. However, it’s important to note that further research is needed to establish the efficacy and safety of coluracetam as a synthetic nootropic drug. solely sells Coluracetam for laboratory research purposes.

When purchasing Coluracetam, it is critical to select a trusted source that offers high-quality items. At, each product is accompanied by a third-party-issued Certificate of Analysis demonstrating the product’s identity, purity, and concentration.

RCD. Bio also sells Coluracetam in tablet and powder form for research purposes.

According to some studies, a powder form can contain more vital nutrients than a tablet or capsule. In powder form, researchers can provide a much broader spectrum of effects.


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PLEASE NOTE: All products offered by are strictly intended for laboratory and research purposes only. They are not intended for use on animals or humans.