Cyanidin 3-glucoside (C3G) is a naturally occurring phenolic compound commonly found in dark-colored fruits, plants, and vegetables, such as blackberry extract. This compound has garnered significant attention due to its potential health benefits, particularly its relative antioxidant activities that combat oxidative stress in the body.
While research into the benefits of C3G is ongoing, it holds promise in various human intervention studies, including diabetes management, cardiovascular diseases, and potential anticancer properties.
Also, a reliable high-performance liquid chromatography (HPLC) method for determining the C3G and C3R contents in mulberry fruit was developed and validated using pure C3G and C3R.
Many people take Cyanidin 3-glucoside to increase muscle mass, endurance, and weight loss. Some users report positive outcomes, while others are skeptical that C3G made any discernible difference.
Disclaimer: The information provided here is for informational purposes only and should not be considered a substitute for professional medical advice. Consult with a healthcare provider before incorporating C3G or any dietary compound into your routine, especially if you have underlying health concerns or conditions.
C3G 20% Extract Tablets Product Details
Cyanidin 3-glucoside (C3G), also known as Chrysanthemin, belongs to the anthocyanin family of pigments responsible for the vibrant blue, red, or black hues found in various plant tissues, including those that undergo color changes in autumn. C3G is naturally present in a variety of anthocyanin-rich extract foods, such as blueberries, acai, and black soybeans, making it a rich source of potent antioxidants.
While preclinical studies conducted on animals and cells have indicated its potential benefits, including antioxidant activity and protective effects against conditions like metabolic syndrome and insulin resistance, it’s crucial to note that clinical evidence supporting these claims in human health is currently limited.
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Potential Benefits of C3G 20% Extract Tablets
The existing animal and cell-based studies are summarized below; they should guide future research efforts but should not be interpreted as supporting any health benefit.
In laboratory experiments, cyanidin 3-glucoside (C3G) has shown the ability to reduce fat tissue and cells in mice fed a high-fat diet and exhibiting elevated blood fat levels. C3G was found to enhance fat cell differentiation, which is typically impaired in diabetes. This suggests a potential role for C3G in managing obesity-related aspects of diabetes and reducing hepatic steatosis. [R]
Research involving diabetic mice revealed that C3G led to a decrease in fasting blood glucose levels. Additionally, it appeared to mitigate diabetic complications by protecting the kidneys, liver, and pancreas from damage. [R]
A statistical analysis of various rodent studies indicated that C3G supplementation could enhance insulin sensitivity, increase insulin secretion, and reduce post-meal blood glucose levels in treated groups. These findings highlight C3G’s potential to improve blood sugar regulation. [R]
Vascular Failure Prevention
Preclinical research has suggested that C3G can lower cholesterol levels, potentially contributing to improved heart health. Berry extracts containing C3G were found to reduce cholesterol levels in rats subjected to a high-cholesterol diet while increasing high-density lipoprotein (HDL) cholesterol, considered beneficial. [R]
Studies involving diabetic rats indicated that those treated with cyanidin 3-glucoside experienced less heart damage that could lead to heart disease compared to the control group. This suggests a potential cardioprotective role for C3G in participants with diabetes. [R]
C3G was also observed to have an inhibitory effect in the process of platelet aggregation when applied to human blood platelets from both healthy men and women. This anti-platelet effect may contribute to the prevention of atherosclerotic plaque formation. [R]
Research conducted on rats demonstrated that C3G could reverse symptoms associated with metabolic syndrome, including excess belly fat, elevated glucose levels, and high blood pressure. This suggests that C3G may be beneficial for participants at risk of health issues related to metabolic syndrome. [R][R]
Dietary supplementation with cyanidin 3-glucoside was shown to reverse signs of liver damage in mice with liver injuries over an eight-week period. This protective effect was attributed to the reduction of inflammation and cell death in the liver, indicating the potential for C3G in liver health. [R]
H. Pylori Infection
In a study involving human stomach cells affected by Helicobacter pylori (H. pylori) infection, cyanidin 3-glucoside demonstrated the ability to reduce cell death by blocking the release of toxins. This suggests a potential role for C3G in protecting against the harmful effects of H. pylori infection in the digestive system. [R]
C3G-rich extracts from black rice have demonstrated effects on body weight and food intake in animal studies, raising the possibility of its utility in obesity management. While many of these effects were observed in animal models, the consumption of anthocyanin-rich foods containing C3G has been associated with potential health benefits in humans. [R]
Potential Anticancer Properties
Emerging research has hinted at the potential anticancer properties of C3G, although further investigations are necessary to substantiate these claims. Preliminary studies have suggested that C3G may inhibit the growth of certain cancer cells and reduce the risk of cancer development, but this research is still in its early stages. [R]
Heart Disease Prevention
A certain study found that supplementing with cyanidin-3-O-β-glucoside (Cy-3-G) offers a potential protection against endothelial dysfunction caused by high cholesterol levels in apolipoprotein E-deficient mice. Additionally, it may help reduce the development of atherosclerosis. One noteworthy discovery was that a metabolite called PCA, which originates from Cy-3-G, effectively inhibits the infiltration of monocytes in these ApoE-deficient mice. [R]
This finding suggests that the antiatherogenic (atherosclerosis-preventing) effect of foods or extracts rich in Cy-3-G may be due, in part, to PCA. Therefore, future research should focus on exploring the biological properties of polyphenol metabolites, not just the polyphenols themselves. [R]
To summarize, this study demonstrated that Cy-3-G is efficiently converted into PCA within the ApoE-deficient mice. It also showed that both Cy-3-G and PCA treatments may reduce monocyte/macrophage infiltration, both in laboratory settings and in living organisms, by negatively influencing the expression of CCR2. [R]
This suggests that Cy-3-G and its metabolite PCA may hold potential clinical significance in reducing the severity of atherosclerosis, a condition characterized by the buildup of plaque in arteries. [R]
How It Works
The mechanism of action of cyanidin 3-glucoside (C3G) is an active area of human studies, offering promising insights into its positive effects. Preliminary experiments suggest that C3G exerts its inhibitory effects through powerful antioxidant activity, mitigating oxidative stress in the body and thereby potentially protecting the heart and blood vessels.
Furthermore, C3G-containing anthocyanin extracts have been shown to increase the activity of proteins involved in fat tissue regulation, with UCP-2 being of particular interest as a potential genetic marker and treatment target for type II diabetes.
C3G may also play a role in immune system modulation, potentially reducing Th2-dominant immune responses associated with hyperactive allergic reactions. It’s important to note that C3G’s activation in the body requires specific enzymes to convert it from its precursor, cyanidin 3-rutinoside, and its digestion and absorption remain areas of investigation.
Studies suggest that less than 1% of C3G may be utilized, and it may undergo further conversion into active compounds yet to be identified. Interestingly, the presence of human gut bacteria may enhance C3G digestion, underscoring the role of the intestinal environment in its utilization.
Ongoing research, including clinical trials and studies on bioavailability, will provide a deeper understanding of C3G’s mechanisms of action and potential health benefits.
When researching the use of Cyanidin 3-Glucoside (C3G), it is essential to take certain precautions. Here are some precautions to keep in mind:
Observe best practices for studying research chemicals
Studying research chemicals requires a responsible and informed approach to ensure safety and meaningful scientific exploration. Research chemicals, also known as designer drugs or experimental compounds, are substances synthesized for scientific investigation or exploration of their properties.
Follow the recommended dosage
Adhere to the recommended dosage instructions outlined on the product label. Avoid a significant increase of the suggested dose to minimize the risk of potential adverse effects among test subjects.
Safety and Side Effects
Cyanidin 3-glucoside (C3G) is generally considered safe when consumed through a dietary anthocyanin source or fruit extract such as bilberry extract, berries, and other anthocyanins plant-based foods. However, when taken in supplement form, the safety profile is less well-established, and potential side effects may vary among participants.
Commonly reported side effects of C3G include gastrointestinal issues such as stomach discomfort, diarrhea, or nausea.
In conclusion, Cyanidin 3-glucoside (C3G) has shown promising health benefits across a spectrum of research areas. In in vivo and colon cells studies involving diabetic mice and rats, C3G demonstrated its potential to ameliorate hyperglycemia, reduce fasting blood glucose levels, and enhance insulin sensitivity, indicating its potential as an aid in diabetes management. Furthermore, C3G exhibited significant antioxidant properties, protecting against oxidative stress and DNA stability. It played a role in reducing lipid peroxidation and promoting gene expression related to fat tissue regulation.
C3G has also displayed potential cardiovascular benefits, as evidenced by its ability to atherosclerotic plaque stabilization and mitigate the effects of peroxynitrite-induced endothelial dysfunction. In studies involving apolipoprotein vitamin E-deficient rats, it showed promise in reducing heart damage. Additionally, C3G exhibited inhibitory effects on Th2 immune responses, potentially benefiting those with hyperactive allergic reactions.
When it comes to weight management, C3G-rich extracts from black rice have demonstrated effects on body weight and food intake in animal studies, raising the possibility of its utility in obesity management. While many of these effects were observed in animal models, the consumption of anthocyanin-rich foods containing C3G has been associated with potential health benefits in humans.
However, it is essential to note that the efficacy of C3G supplements in humans is still inconclusive, and caution should be exercised when considering high doses or prolonged use, especially due to limited data on long-term safety. Additionally, the potential interactions of C3G with other phenolic compounds and its response to direct sunlight exposure warrant further investigation.
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