Dihexa is a peptide that has shown noticeable effects in combating dementia, a known neurological disease, in aged rat models, suggesting its potential as a therapeutic agent. Initially created by dedicated researchers at Washington State University, this compound has exhibited high specificity and the ability to effectively penetrate the brain.

Notably, in animal models simulating mental impairment akin to Alzheimer’s disease, this peptide has demonstrated the potential to enhance cognitive function. Moreover, multiple animal studies have indicated its potential to promote synaptogenesis, facilitate the formation of new connections between brain cells, and aid in memory recovery.

However, Dihexa is recognized as a research compound meaning it should be purchased for laboratory uses only.

Dihexa Product Details

This peptide is a derivative of angiotensin IV (ANG IV), which is a metabolite of ANG, a protein known for its role in raising blood pressure by constricting blood vessels. ANG IV-related peptides have garnered widespread recognition as pro-cognitive agents and hold significant potential as anti-dementia therapeutics.

Multiple animal studies have provided evidence of its ability to enhance cognitive functions, restore memory, and alleviate cognitive impairment. These findings suggest that Dihexa, the peptide in question, may have therapeutic applications in the treatment of Alzheimer’s disease.

Notably, research has indicated that Dihexa possesses metabolic stability, enabling it to potentially cross the blood-brain barrier. Additionally, it exhibits a long-circulating half-life of 12.68 days, distinguishing it from other ANG-IV analogs that are generally unable to penetrate the blood-brain barrier.

Dihexa could also allegedly accelerate wound healing, enhance anabolic development, and prevent muscular atrophy.

Even so, more in-depth studies are needed to confirm Dihexa’s potential health advantages.

Key Features of Dihexa

  • 98% Purity
  • 30ml/17mg per ml/500mg
  • Sold for research purposes only

Potential Benefits of Dihexa

Dihexa and Inflammation

Studies involving mice have demonstrated the ability of Dihexa to decrease the levels of pro-inflammatory cytokines and increase the levels of the anti-inflammatory factor IL-1. Furthermore, Dihexa has been shown to inhibit inflammation in additional research. Another study in rats showed that ANG IV, the analog Dihexa is derived from, dose-dependently suppressed inflammation in the brain. These results are particularly relevant considering that Dihexa possesses an extended half-life and improved ability to penetrate the blood-brain barrier compared to ANG IV. [R][R][R]

Dihexa and Dementia

Dihexa has demonstrated its potential in combating dementia, a popular neurodegenerative disease, based on research conducted in scopolamine and aged rat models. It has been identified as an analog of ANG-IV and has been shown to exhibit anti-dementia activity. Additionally, Dihexa has been recognized as a marker of synaptogenic activity, which is crucial because synaptic proteins play a vital role in synaptic plasticity and cognitive function. [R]

In an animal study, Dihexa administration resulted in increased neuronal cell numbers and expression of SYP protein in mice. This is particularly significant as decreased levels of SYP protein are observed in elderly individuals with dementia, making it one of the major contributing factors to Alzheimer’s disease. These findings suggest that Dihexa may hold therapeutic potential in the treatment of neurological diseases, such as Alzheimer’s, where enhancing synaptic connectivity could be beneficial. [R]

Dihexa and Synaptogenesis

Synaptogenesis, the process of forming connections (synapses) between neurons in the nervous system, is critical for learning, memory formation, and early-life adaptation. It also plays a crucial role in establishing precise brain circuitry. Numerous studies and animal models have demonstrated that Dihexa has the capacity to promote synaptogenesis. [R][R]

Notably, its ability to activate HGF has been identified as the underlying mechanism responsible for its synaptogenic activities. The impact of Dihexa on synaptogenesis mirrors that of HGF, further emphasizing its potential role in enhancing synaptic connectivity. [R]

Dihexa and Cognition

In a mice study, Dihexa exhibited potent improvement in cognitive function. The research indicated that Dihexa not only rescued cognitive impairment but also facilitated memory recovery by ameliorating neuronal loss and inhibiting inflammation and glial activation. This study specifically utilized APP/PS1 mice, a commonly employed animal model for Alzheimer’s disease research. [R]

Another study focusing on cognitive function in animal models showed that administering Dihexa to APP/PS1 mice for a three-month period resulted in the rescue of cognitive impairment and improved memory. These findings highlight the potential of Dihexa in addressing cognitive decline associated with neurological disorders. [R]

How It Works

Dihexa exhibits potential working mechanisms that contribute to its beneficial effects, as outlined below:

One of the identified mechanisms involves the activation of the hepatocyte growth factor (HGF) system. In a study conducted on mice, Dihexa was observed to bind with high affinity to HGF, a substance that serves various functions in the brain and body of mice. The study revealed that Dihexa’s pro-cognitive and synaptogenic effects are dependent on its activation of the HGF system, indicating the importance of this pathway in mediating its cognitive-enhancing properties.

Furthermore, multiple animal studies have demonstrated that Dihexa has the potential to increase the synthesis of new synapses, which are the connections between neurons in the brain. This ability of Dihexa to induce synaptogenesis provides an explanation for its pro-cognitive and anti-dementia properties. The formation of new synapses is crucial for optimizing cognitive function and preventing cognitive decline.


When researching the use of Dihexa, it is essential to take certain precautions. Here are some precautions to keep in mind:

Observe best practices for studying research chemicals: Studying research chemicals requires a responsible and informed approach to ensure safety and meaningful scientific exploration. Research chemicals, also known as designer drugs or experimental compounds, are substances synthesized for scientific investigation or exploration of their properties.

Follow recommended dosage: Adhere to the recommended dosage instructions outlined on the product label. Avoid exceeding the suggested dose to minimize the risk of potential adverse effects among test subjects.


In conclusion, Dihexa, a potent vasoconstrictor angiotensin II peptide variant derived from angiotensin IV, has shown significant potential in improving cognitive function based on studies conducted in animal models. This peptide variant, administered centrally, has exhibited neurotrophic activity and the ability to enhance acquisition and anabolic development.

Moreover, it has demonstrated effects in accelerating wound healing, preventing muscular atrophy, and addressing neurodegenerative diseases. Although these still require more studies.

However, it is crucial to note that further research and clinical trials are necessary to ascertain its efficacy and safety in human use.


Please take note of the scientific applications of this product and carefully read our Terms and Conditions before purchasing By completing your order and submitting payment, you agree to abide by the Terms and Conditions of our company. Please be aware that the product packaging may differ slightly from the images displayed on our website.

If for any reason you are not completely satisfied with the product you receive, please contact us at [email protected]. Our team is dedicated to ensuring satisfaction among our customers.

PLEASE NOTE: All products offered by are strictly intended for laboratory and research purposes only. They are not intended for use on animals or humans.