DMHA, also known as dimethylhexylamine, is a potent central nervous system stimulant that has shown promising effects on dopamine and noradrenaline uptake. It is referred to by various names, including 2-amino-6-methylheptane, 2-metil-5-amino-eptano, Octodrine, Amridine, Vaporpac, and Hi-Tech Pharmaceuticals Synadrene.

Originally developed as a nasal congestion medication, DMHA has garnered attention due to its potential to increase energy levels, improve focus, and raise the heart rate. While most of the evidence supporting these effects comes from animal studies, DMHA has also demonstrated pain-suppressing properties.

Even though DMHA is believed to possess the above-mentioned benefits, it is not a safe dietary supplement for human consumption. Purchase DMHA for research purposes only.

DMHA Product Details

Dimethylhexylamine (DMHA) is a potential central nervous system stimulant that was initially synthesized in the 1950s as a potential medication for nasal decongestion. While it was briefly approved for this purpose, it is no longer authorized for medical use, including nasal decongestion treatment.

Structurally, DMHA bears some resemblance to certain pre-workout weight loss supplements. One good example would be Ephedrine, an illegal pre-workout supplement that has been banned for any form of use in the United States. Other pre-workout supplements that have a similar structure to DMHA, such as AMP citrate and 1-3DMAA, are also prohibited.

Several preclinical studies have been conducted to investigate the effects of DMHA since its development in the 1950s. These studies have observed increased nasal and lung volume, elevated blood pressure, and the elimination of stationary phase E. coli from the body. It is important to note that these findings are based on animal and/or cell-based research, and no placebo-controlled trials have been conducted. To obtain comprehensive information about DMHA, it is advisable to consult with your medical healthcare provider.

  • CAS Number 543-82-8
  • Molar Mass 129.247 g·mol−1
  • Chemical Formula C8H19N
  • IUPAC Name 6-methylheptan-2-amine

Key Features of DMHA

  • 98% Purity
  • 1g
  • Sold for research purposes only

Potential Benefits of DMHA Powder

DMHA and Hypotension

Hypotension, characterized by low blood pressure levels, can have detrimental effects on cardiovascular health. Studies conducted in different time periods have explored the potential effects of DMHA on blood pressure regulation. A study conducted in 1974 investigated the effects of DMHA in combination with three other drugs on patients with hypotension, showing promising results in altering blood pressure levels. [R][R]

Similarly, a preclinical study in 1951 demonstrated increased blood pressure in a dog after exposure to DMHA. Furthermore, an earlier study from 1947 observed an increase in cardiac rate and the amplitude of heart muscle contraction in an experimental animal exposed to DMHA. While these findings suggest a potential influence of DMHA on blood pressure, further research is needed to establish its efficacy and safety in addressing hypotension. [R][R]

DMHA and Nasal Congestion

Research conducted in the 1950s shed light on the potential benefits of DMHA in alleviating nasal congestion. A preclinical study conducted in 1950 examined the effects of DMHA and two other aliphatic amines on respiratory volume in animals. It was found that all three substances increased respiratory volume, indicating their potential decongestant properties. [R]

A subsequent study in 1951 focused specifically on DMHA and observed increased nasal and lung volume in a dog, further supporting its potential for decongesting airways. Additional studies conducted in 1958 and 1960 arrived at the same conclusion, reinforcing the respiratory effects of DMHA in decongesting airways. [R][R][R]

DMHA and E. coli Bacteria

Escherichia coli (E. coli) is a bacteria commonly associated with urinary tract infections. In 2015, a study aimed to explore the effects of DMHA on stationary phase E. coli. The results indicated that DMHA not only eliminated the bacteria but also exhibited significant anti-persister activity. Additionally, DMHA was found to effectively eradicate all persister cells after a five-day exposure period. These findings suggest the potential antimicrobial properties of DMHA against E. coli bacteria, particularly those in the stationary phase. [R]

It is important to note that while these studies provide valuable insights into the potential effects of DMHA, many of the findings are based on preclinical research or observations in animals. Further research, including well-designed clinical trials, is necessary to establish the efficacy, safety, and optimal usage of DMHA in human populations. Consulting with medical professionals is advised for comprehensive information and guidance on the use of DMHA. [R]

DMHA and Pain Threshold

To understand the effects of DMHA on pain sensitivity, a preclinical study was conducted using experimental animals such as rabbits, cats, and dogs. The animals were administered specific doses of DMHA, and their responses to pain-inducing stimuli were observed. The study revealed that DMHA exhibited local anesthesia properties, as it elevated the local pain threshold in the animals. [R]

However, it is important to note that these findings are based on preclinical studies, and further investigation, including randomized clinical trials, is necessary to ascertain the potential effects of DMHA on pain threshold in humans. [R]

How It Works

DMHA may have the potential to enhance the uptake of dopamine and noradrenaline, two crucial neurotransmitters that perform diverse and important functions in the brain. Dopamine, for example, is involved in regulating pleasure, movement, and memory, playing a vital role in these processes. On the other hand, noradrenaline is responsible for modulating the body’s fight or flight response, helping to regulate and respond to stressful situations.


When researching the use of DMHA, it is essential to take certain precautions. Here are some precautions to keep in mind:

Observe best practices for studying research chemicals: Studying research chemicals requires a responsible and informed approach to ensure safety and meaningful scientific exploration. Research chemicals, also known as designer drugs or experimental compounds, are substances synthesized for scientific investigation or exploration of their properties.

Follow recommended dosage: Adhere to the recommended dosage instructions outlined on the product label. Avoid exceeding the suggested dose to minimize the risk of potential adverse effects among test subjects.


In conclusion, the use of dimethylhexylamine (DMHA) holds potential benefits across various areas. Originating from ancient Chinese herbal medicine, DMHA has garnered attention in recent years for its diverse applications in research and formulations.

As a key ingredient in pre-workout research chemicals, DMHA offers a natural energy boost and can enhance focus. Additionally, DMHA has shown potential as a powerful diet aid, commonly found in fat burners and appetite suppressants. Its ability to increase the pain threshold may have implications for those seeking accurate measurements of their physical abilities or managing discomfort during exercise.

Studies have indicated that DMHA acts as a potent fat burner. Its stimulating effects on the central nervous system can boost energy levels.

Furthermore, DMHA has demonstrated the potential to dilate blood vessels, which can improve blood flow and potentially enhance athletic performance. The half-life of DMHA allows for sustained effects, making it suitable for prolonged physical activities or demanding workouts.

It is worth noting that DMHA shares some similarities in its effects with geranium extract, and both substances have been used to provide energy and stimulate the body. However, accurate measurements and scientific research are necessary to fully understand the potential benefits and safety profile of DMHA.


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