Echinacea Purpurea Cichoric Acid 2%

Cichoric acid, one of the primary phenolic compounds present in the flower of Echinacea purpurea extract, is a member of a group of substances known as caffeic acid derivatives. It has been used for generations as a traditional herbal treatment and is thought to potentially support a healthy immune system.

The perennial herb Echinacea purpurea produces cichoric acid, a natural substance, in the flower heads. Along with Echinacea angustifolia and Echinacea pallida, which have also been investigated for their potential health advantages, Echinacea purpurea is a species of the Echinacea plant family. [R]

Long before the arrival of European medicines, North American plains residents used herbal remedies made from various species of the native Echinacea genus, primarily as possible relief from various infectious diseases and wounds. [R]

Pure cichoric acid or chicoric acid, is a phenolic molecule that has been researched for potential health advantages, is one of the plant’s active ingredients. According to studies, Echinacea purpurea extract, particularly chicoric acid biosynthesis, may have anti-inflammatory qualities and be useful in treating the symptoms of the common cold. Additionally, it has been investigated for its potential to support immune function and antioxidant properties. [R]

Key Features offers Echinacea purpurea cichoric acid  with the following specifications:

  • A purity of 98%, verified by third-party laboratory testing.
  • Available in tablet form with two dosages 20mg/27ct/540mg and 20mg/54ct/1g

Chemical Profile Echinacea Purpurea Cichoric Acid

  • CAS Number: 6537-80-0
  • Molar Mass: 474.371 g/mol-1
  • Chemical Formula: C22H18O12
  • IUPAC Name: (2R,3R)-2,3-bis{[(E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]oxy}butanedioic acid

Overall, Echinacea purpurea cichoric acid is a natural substance that may provide a number of health advantages, but additional research is required to completely comprehend its effects.

How E. Purpurea Cichoric Acid Works?

Numerous in vivo investigations have been done on Echinacea Purpurea immunomodulatory and anti-inflammatory properties. E. purpurea implies that treatment of the plant improves innate immunity and that the activation of neutrophils, macrophages, polymorphonuclear leukocytes (PMN), and natural killer (NK) cells strengthens the immune function against pathogenic infections. [R]

In another reference, cichoric acid raises the synthesis of cytokines, which are signaling molecules that control the immune response, and white blood cell activity, studies have demonstrated that cichoric acid may help strengthen the body’s natural defenses. [R]

Additionally, a study found that Echinacea purpurea extract from stems, leaves, and roots as well as purified cichoric acid, exhibited antioxidant activity in different tests which may suggest oxidative stress protection in cells which may have potential health benefits. However, it is important to note that this is just one study, and more research is needed to confirm these findings and understand the full range of potential health effects of Echinacea purpurea and its constituents. [R]

The scientific basis behind the benefits of Echinacea Purpurea Extract

Immune System Support

In a study that was published in the Journal of Ethnopharmacology, the immune system may be supported by echinacea purpurea extract, which includes cichoric acid, by promoting the generation of white blood cells and other immune cells. Researchers examined E. purpurea preparations using high-performance liquid chromatography They discovered that the echinacea purpurea extract included cichoric acid as well as other substances like chlorogenic acid and caftaric acid. According to the study’s findings, these bioactive substances may help explain some of echinacea purpurea’s possible immune-boosting properties. [R]

Anti-inflammatory Properties

In the Journal of Agricultural and Food Chemistry, E. purpurea cichoric acid may have anti-inflammatory properties. In laboratory research, researchers employed simultaneous analysis in a study that was published to measure the concentrations of bioactive compounds in fresh plant material. They discovered that there were high quantities of cichoric acid. Alkamides and polysaccharides, among other bioactive substances with anti-inflammatory properties, were also discovered in E. purpurea tissues, according to the study. [R]

Anti-aging  Properties

Furthermore, a study discovered that cichoric acid and echinacoside (other caffeic acid derivatives) together exhibited anti-aging properties in a test subject skin cells. Collagen and elastin, which are crucial proteins for the health and elasticity of the skin, were discovered to be produced in greater amounts when the two substances were combined, according to the researchers. [R]


Cichoric acid extract (CAE) from E. purpurea was used to investigate the anti-arthritic effect by using collagen-induced arthritis (CIA) rat model. Histopathological analysis demonstrated that CAE has obvious anti-arthritic activity. The results suggest that the aanti inflammatory properties of CAE may account for its anti-arthritic effect, and CAE could be a potential drug for rheumatoid arthritis (RA). [R]

In another study, the effect of cichoric acid on the inflammatory response caused by the deposition of monosodium urate in synovial joints, which characterizes gouty arthritis was investigated. The experiment involved macrophages that were treated with cichoric acid. The study suggests that cichoric acid may possibly alleviate induced inflammation and prevent acute episodes of gout. [R]

Potential Cancer-Fighting Properties

A study published in the Journal of Medicinal Food suggests that cichoric acid from E. purpurea may have potential in cancer treatment, based on laboratory research. The study found that an Echinacea purpurea extract tested in colon cancer cells could potentially prevent the growth of cancer cells. [R]

More clinical trials are required to fully comprehend the potential advantages of using E. purpurea cichoric acid, even though laboratory research has yielded encouraging results.

Antiviral Activity and Caffeic Acid Derivatives

Cichoric acid from Echinacea purpurea had antiviral properties against influenza A virus. The researchers found that cichoric acid was able to inhibit viral replication in vitro, suggesting that it could be a potential natural remedy for the flu. [R]

Later studies supported the concept of Echinacea species as a potential source of antiviral activities. Cheminat et al. [R] isolated and characterized a group of caffeoyl derivatives from dried and fresh Echinacea pallida plants, and examined two of them, cichoric acid and echinacoside, as well as caffeic acid, a constituent of E. purpurea, for activity against the replication of vesicular stomatitis virus (a membrane containing RNA virus) in a mouse cell line. Though activity was relatively weak, it may suggest the compound’s potential.

Binns et al. [R] examined extracts from a variety of different species and plant parts for antiviral activity against herpes simplex virus. Assays were designed to test virucidal activity or viral growth inhibition, and they also incorporated exposure to light in case photosensitizers were involved (these are often found as active substances of medicinal plants). Pure cichoric acid was also moderately active, and could therefore contribute to the activity of certain extracts. 


The information presented here is for educational purposes only and should not be construed as medical advice. E. Purpurea cichoric acid is intended for laboratory and research use only and is not intended for human consumption.

Potential Side Effects [R1; R2]

E. Purpurea cichoric acid is usually regarded as safe when used as intended, however, some participants may experience negative effects, according to certain research data. Gastrointestinal symptoms such as nausea, stomach discomfort, and diarrhea are the most often reported side effects. Additionally, possible side effects include a rash, headache, and dizziness.

Echinacea preparations may cause adverse allergic reactions in people who are allergic to Asteraceae/Compositae species like daisies or ragweed.

Echinacea purpurea should also be used with caution by people who have autoimmune illnesses or are on immunosuppressant medicines since it may stimulate the immune system.

Frequently Ask Questions (FAQs)

What is Echinacea species?

Echinacea is a genus of herbaceous flowering plants of the Asteraceae family that are indigenous to North America. Echinacea purpurea, Echinacea angustifolia, and Echinacea pallida are the three species that are used the most frequently. The most popular species, Echinacea purpurea, is widely grown for its alleged therapeutic benefits. [R]

Is echinacea a natural antibiotic?

Due to its possible antibacterial and antiviral properties, echinacea is frequently referred to as a natural antibiotic. Specific echinacea ingredients, like alkylamides and derivatives of caffeic acid, may have antimicrobial activity against a variety of bacteria and viruses, according to some laboratory studies. [R]

What is the half-life of cichoric acid?

The pharmacokinetic parameters were determined and showed a half-life (t1/2) of 4.53±1.44h. [R]

Where Can I Buy the Best Echinacea Purpurea Cichoric Acid? offers Echinacea Purpurea Cichoric Acid for laboratory research use only.

When buying Echinacea Purpurea Cichoric Acid, it is important to choose a reputable seller who provides quality products. At, each product is accompanied by a third-party-issued Certificate of Analysis showing the identification, purity, and concentration of our product.

RDC. Bio also offers Echinacea Purpurea Cichoric Acid in Liquid Form

Liquid forms are absorbed more quickly and may have a more immediate effect on your research subjects. Tablets or capsules, on the other hand, may take longer to absorb and may have a slower release of the bioactive components. Ultimately, the choice between tablet form and liquid form may depend on your research purpose.


Cichoric Acid from Echinacea Purpurea has gained attention as a potential dietary supplement due to its reported health benefits. However, it’s important to take caution when considering dietary supplements, as they are not evaluated for safety and effectiveness by the FDA before being marketed. does not promote the use of this research chemical as a dietary supplement but for research purposes only.

It’s important to note that while Echinacea has a long history of use in traditional medicine as an herbal remedy, many of its reported benefits have not been substantiated by scientific research. According to anecdotal reports, the leaves and roots of the plant have been used by American Indians to treat a range of issues, including toothaches, snakebites, insect bites, and skin wounds. While some studies suggest that Echinacea may have therapeutic potential for certain conditions, such as bronchitis and urinary tract infections, more research is needed to fully understand its effects on human health.


A bioactive component of echinacea plants called Echinacea purpurea cichoric acid has been the focus of numerous laboratory and clinical studies for its possible medicinal benefits.

The bioactive component Echinacea purpurea cichoric acid is one of those compounds, according to biological testing and quantitative analysis. Echinacea purpurea root extract has also been the subject of studies examining the extraction method and principal component analysis, which may aid in maximizing the production of high-quality extracts for nutritional supplements and other items.

It is a promising possible treatment option for several ailments. Most available published research somehow shows evidence that may suggest that it may have immunomodulatory and anti-inflammatory properties.


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PLEASE NOTE: All products offered by are strictly intended for laboratory and research purposes only. They are not intended for use on animals or humans.