HBT1 powder is a form of the compound HBT1, which is an AMPA receptor potentiator. It is a substance that has been synthesized and formulated into a powder for various applications. HBT1 powder is known for its potential benefits in promoting brain health and functioning.

HBT1 powder allegedly induces the production of brain-derived neurotrophic factor (BDNF). BDNF is a crucial protein that supports the growth, survival, and maintenance of neurons in the brain. By stimulating BDNF production, HBT1 powder may contribute to improved neuronal plasticity, synaptic transmission, and overall cognitive functions such as learning and memory.

Furthermore, HBT1 powder has shown potential neuroprotective effects. It may help prevent or reduce neuronal loss in conditions associated with decreased BDNF levels, such as neurodegenerative diseases like Parkinson’s disease, Alzheimer’s disease, and multiple sclerosis.

Despite the mentioned possible benefits, HBT1 powder is considered a research chemical. For this reason, buy this product for research purposes only.

HBT1 Powder Product Details

HBT1, also known as 2-[[2-[4-(ethylaminomethyl)-3-(trifluoromethyl)pyrazol-1-yl]acetyl]amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide, is an AMPA receptor potentiator with a Molecular Weight of 386.39. It is a compound that stimulates the production of brain-derived neurotrophic factor (BDNF) and has minimal agonistic effects on primary neurons. Another synonym for HBT1 is 2-[({4-[(Ethylamino)methyl]-3-(Trifluoromethyl)-1h-Pyrazol-1-Yl}acetyl)amino]-4,5,6,7-Tetrahydro-1-Benzothiophene-3-Carboxamide.

BDNF, the protein known as the brain-derived neurotrophic factor, plays an essential role in the maintenance and growth of neurons. It acts as a neurotransmitter modulator and contributes to neuronal plasticity, which is essential for learning and memory.

Reduced levels of BDNF have been associated with neurodegenerative diseases characterized by neuronal death, including Parkinson’s disease, Alzheimer’s disease, multiple sclerosis, and Huntington’s disease.

Increasing BDNF levels may have potential benefits in the treatment and prevention of various disorders. Therefore, HBT1’s ability to stimulate BDNF production holds promise for therapeutic applications.

  • CAS Number 489408-02-8
  • Molar Mass 386.39g.mol-1
  • Chemical Formula C16H17F3N4O2S
  • IUPAC Name 2-(((5-Methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl)acetyl)amino)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide

Key Features of HBT1 Powder

  • 98% Purity
  • 1g
  • Sold for research uses only

Potential Benefits of HBT1 Powder

HBT1’s Implications for Neurological Diseases

As mentioned earlier, HBT1 has the ability to increase BDNF levels. This elevation of BDNF suggests that exogenously administered BDNF could potentially prevent neuronal loss and reduce the susceptibility of nigral neurons to glutamate inputs, making it potentially beneficial for conditions such as Huntington’s and Parkinson’s diseases. [R]

BDNF also plays a crucial role in neurogenesis, the process of generating new neurons. It is expressed at the protein and mRNA levels in various regions of the brain, including the olfactory bulb, cortex, hippocampus, basal forebrain, mesencephalon, hypothalamus, brainstem, and spinal cord. [R]

Numerous neurodegenerative diseases, such as Parkinson’s disease (PD), multiple sclerosis (MS), and Huntington’s disease, are associated with decreased BDNF levels. Therefore, interventions that can boost BDNF production, such as HBT1, hold potential therapeutic value for these conditions. [R]

BDNF not only protects neurons but also helps regulate energy levels. When BDNF is administered outside the brain or directly into the brain (intracerebroventricularly, or ICV), it suppresses appetite and induces weight loss. [R]

To fully understand the role of HBT1 in modulating BDNF production and its potential impact on various neurological disorders, further extensive research is needed. Investigating the specific mechanisms by which HBT1 influences BDNF synthesis and exploring its therapeutic implications are important areas of future investigation. [R]

HBT1’s Impact on Brain-Derived Neurotrophic Factor (BDNF)

Brain-derived neurotrophic Factor (BDNF) is a critical neurotrophin that plays a multifaceted role in the proliferation, differentiation, survival, and apoptosis of neuronal and non-neuronal cells, making it essential for the overall health and functioning of the nervous system. [R]

HBT1, a novel AMPA receptor potentiator, exhibits reduced agonistic effects on primary neurons and lacks a bell-shaped response in in-vitro BDNF synthesis, indicating its potential to modulate BDNF levels without negatively affecting neuronal activity. [R]

How It Works

HBT1 exhibits a glutamate-dependent binding to the ligand-binding domain of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPA-R).

This characteristic of HBT1 implies that it selectively interacts with a specific site on the AMPA-R protein only when glutamate is present. The binding of HBT1 to AMPA-R helps modulate the protein’s activity.

AMPA receptors are widely expressed throughout the central nervous system (CNS) and play vital roles in neuronal communication, sensory processing, as well as learning, memory, and synaptic plasticity.

As the primary mediators of excitatory neurotransmission, AMPA receptors facilitate the rapid and transient excitation of numerous synapses. They are involved in the initial response to glutamate in the synaptic region. Activation of AMPA receptors leads to the influx of sodium ions through the channel’s pore, resulting in membrane depolarization.

This change in intracellular charge causes the displacement of Mg2+ ions from the N-methyl-D-aspartate (NMDA) receptor channel, enabling the flow of Ca2+ through the pore. AMPA receptors are composed of a complex of four subunits (GluR1-4), which can form homomeric or heteromeric configurations.

The functional diversity and complexity of AMPA receptors arise from various factors such as differences in subunit expression, posttranscriptional modifications, alternative splicing, and their effects on desensitization time and receptor trafficking.

AMPA receptors are commonly co-expressed with NMDA receptors at synapses, where they collaboratively contribute to synaptic plasticity mechanisms involved in learning, memory formation, excitotoxicity, and neuroprotection.


When researching the use of HBT1 Powder, it is essential to take certain precautions. Here are some precautions to keep in mind:

Observe best practices for studying research chemicals: Studying research chemicals 

requires a responsible and informed approach to ensure safety and meaningful scientific exploration. Research chemicals, also known as designer drugs or experimental compounds, are substances synthesized for scientific investigation or exploration of their properties.

Follow recommended dosage: Adhere to the recommended dosage instructions outlined on the product label. Avoid exceeding the suggested dose to minimize the risk of potential adverse effects among test subjects.

Safety and Side Effects

Side effects of nootropics are infrequent and generally not severe. While most test subjects tolerate them well, there are rare instances where certain side effects may arise. These can include increased activity in an unintended direction, disruptions in sleep patterns, or occasional changes in libido. It’s important to note that these side effects are not commonly reported and typically occur in isolated cases.


In conclusion, the use of HBT1 powder, a novel AMPA receptor potentiator, has shown promising benefits in various aspects of brain health and function. By binding to the ligand-binding domain of the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPA-R) in a glutamate-dependent manner, HBT1 powder acts as a catalyst for the induction of brain-derived neurotrophic factor (BDNF) production.

Unlike other compounds, HBT1 powder exhibits a lower agonistic effect on primary neurons, making it a desirable option for those seeking positive results without undue stimulation. Its unique molecular structure, including the presence of methyl-3-trifluoromethyl-1H-pyrazol, further contributes to its effectiveness.

The increased BDNF production elicited by HBT1 powder offers a multitude of benefits. It supports neuronal growth, survival, and plasticity, leading to improved cognitive functions such as learning and memory. Additionally, the neuroprotective properties of HBT1 powder may help mitigate the neuronal loss associated with various neurodegenerative diseases.


Please take note of the scientific applications of this product and carefully read our Terms and Conditions before making a purchase from By completing your order and submitting payment, you agree to abide by the Terms and Conditions of our company. Please be aware that the product packaging may differ slightly from the images displayed on our website.

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PLEASE NOTE: All products offered by are strictly intended for laboratory and research purposes only. They are not intended for use on animals or humans.