The HGH fragment 176-191, derived from the C-terminus of Human Growth Hormone (HGH), is believed to exhibit several potential beneficial effects. In mice, prolonged administration of HGH 176-191 has been found to effectively induce weight loss by affecting obese fat cells. The research chemical may even enhance the sensitivity of lipolysis (lipid metabolism and fat-burning). Due to these properties, HGH 176-191 is commonly referred to as the “lipolytic fragment” of HGH.

Current research has demonstrated that HGH 176-191 may not only reduce body weight but also has the potential to elevate blood glucose levels, as observed in a mice study. Additionally, animal studies have shown that this synthetic HGH fragment can contribute to the promotion of cartilage healing.

Even if HGH Fragment 176 191 could provide the said benefits, this product still requires more in-depth studies one of which is blood sugar research. Buy this compound for research purposes only.

lowers blood sugar levels

HGH Fragment 176 191 Product Details

HGH 176-191 is a synthetic analog of human growth hormone that consists of a peptide chain comprising 16 amino acids. It is commonly known as the “lipolytic fragment” of HGH due to its potential to induce fat loss, as evidenced by research conducted on animals.

Notably, HGH 176-191 has shown promising results as an anti-obesity agent in animal studies. Additionally, a cell-based study has revealed that this modified form of HGH can enhance the anti-cancer effects of compounds targeting breast cancer cells, highlighting its potential therapeutic applications beyond weight loss.

  • CAS Number 97305-48-1
  • Molar Mass 848.9 g/mol-1
  • Chemical Formula C39H60N8O13
  • IUPAC Name (2S)-6-amino-2-[[(2S)-1-[(2S,3S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-4-carboxybutanoyl]amino]-4-carboxybutanoyl]amino]propanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylpentanoyl]pyrrolidine-2-carbonyl]amino]hexanoic acid

Key Features of HGH Fragment 176 191 for Sale

  • 98% Purity
  • 2mg / 5mg / 10mg
  • Sold for research purposes only

Potential Benefits of HGH Fragment 176 191

HGH 176-191 and Osteoarthritis

In a 2016 study, the potential benefits of HGH Fragment 176-191 in treating osteoarthritis were explored using a rabbit model. The study found that the administration of hyaluronic acid (HA) loaded with HGH 176-191 was more effective in promoting cartilage regeneration compared to administering HA or HGH fragments alone. [R]

Additionally, rabbits with osteoarthritis that received intra-articular injections of HGH 176-191 exhibited less morphological and histopathological damage compared to the control group. These findings suggest that HGH 176-191 has the potential to enhance cartilage healing in the context of osteoarthritis. [R]

HGH 176-191 and Fat Loss

In an animal study, the effects of HGH Fragment 176-191 on fat loss were investigated. Over 14 days, administration of HGH 176-191 resulted in a significant reduction in body weight and body fat in obese mice. Researchers attributed this fat loss to the peptide’s ability to increase energy expenditure and enhance fat oxidation. Importantly, the treatment did not negatively impact the animals’ insulin sensitivity, indicating its potential as a safe approach for fat loss. [R]

Another study focused on the lipolytic activity of HGH 176-191 in adipose tissues. Daily oral treatment with this synthetic peptide was found to increase lipolysis in the treated mice. Notably, the treatment had no adverse effects on insulin sensitivity, further supporting its potential as a favorable therapeutic option for fat loss. [R]

HGH 176-191 and Breast Cancer

A cell-based study investigated the impact of HGH Fragment 176-191 on breast cancer cells. It was found that this synthetic peptide enhanced the toxicity of compounds specifically targeting cancer cells in a breast cancer cell line. By utilizing chitosan nanoparticles loaded with HGH 176-191, researchers observed potential enhanced cytotoxic efficacy against breast cancer cells. [R]

This suggests that incorporating HGH 176-191 may improve the delivery of nanoparticles to tumors while minimizing exposure to non-target tissues. Consequently, this approach could enhance therapeutic efficiency and reduce adverse effects associated with this anti-cancer compound. [R]

HGH 176-191 and Obesity

An animal study explored the potential of HGH 176-191 as a therapeutic agent for obesity. Daily oral administration of this peptide resulted in a remarkable reduction of over 50% in body weight gain compared to the control group. These findings indicate that HGH 176-191 holds promise as a safe and effective treatment for obesity. [R]

In another mouse study, chronic treatment with either HGH or its 176-191 fragment exhibited increased oxidation of fat cells and subsequent weight loss in obese mice. Notably, unlike full-length HGH, the 176-191 fragment did not induce hyperglycemia, reduce insulin secretion, or compete for HGH receptors. These properties further establish its potential as a targeted anti-obesity agent. [R]

How It Works

The mechanism of action of Human Growth Hormone (HGH) fragment 176-191 is believed to involve several key processes that contribute to its effects on fat loss.

This synthetic peptide primarily targets adipose (fat) tissues, where it exerts its actions. HGH fragment 176-191 promotes lipolysis, which is the breakdown of stored triglycerides into free fatty acids, leading to the release of energy from fat cells and subsequent fat loss. It also enhances fat oxidation, increasing the body’s ability to utilize fatty acids as an energy source.

The peptide interacts with beta-3 adrenergic receptors present on fat cells, stimulating lipolysis and amplifying the capacity for fat burning. Importantly, HGH fragment 176-191 does not significantly affect insulin sensitivity, making it an advantageous option for fat loss without interfering with glucose regulation. Additionally, this fragment demonstrates reduced diabetogenic potential compared to full-length HGH, minimizing the risk of hyperglycemia.

Some research studies also suggest that fragment 176 191 lowers blood sugar levels since the c-terminal end of the chemical is responsible for its hypoglycemic effects. Although, more in-depth clinical trials are needed to confirm this.


When researching the use of HGH Fragment 176 191, it is essential to take certain precautions. Here are some precautions to keep in mind:

Observe best practices for studying research chemicals: Studying research chemicals requires a responsible and informed approach to ensure safety and meaningful scientific exploration. Research chemicals, also known as designer drugs or experimental compounds, are substances synthesized for scientific investigation or exploration of their properties.

Follow recommended dosage: Adhere to the recommended dosage instructions outlined on the product label. Avoid exceeding the suggested dose to minimize the risk of potential adverse effects among test subjects.

Safety and Side Effects

HGH 176-191 is commonly regarded as a safe compound with minimal side effects, according to some reports. Nonetheless, there are a few potential adverse effects that should be noted. Some test subjects may experience mild injection site reactions, such as redness and itching, which are typically temporary and resolve on their own. It is worth mentioning that these reactions are localized to the injection site and do not typically cause widespread discomfort.

In rare cases, when the recommended dosage limit is exceeded, there have been reports of headaches and dizziness.


In conclusion, the use of Human Growth Hormone (HGH) fragment 176-191 has demonstrated a range of possible benefits that make it a promising chemical for various applications. This synthetic derivative of the natural growth hormone has been found to have a positive impact on fat metabolism and fat burning. HGH fragment 176-191 specifically target adipose tissue, promoting lipolysis and increasing fat oxidation, which contributes to weight loss and reduction in fat accumulation.

Moreover, research has shown that HGH fragment 176-191 plays a role in lowering blood sugar levels, making it potentially beneficial for test subjects with impaired carbohydrate metabolism. By altering insulin sensitivity without negatively affecting glucose regulation, this fragment offers advantages over unmodified growth hormones in managing blood sugar levels.

Beyond its effects on fat metabolism and blood sugar, HGH fragment 176-191 has shown potential in promoting lean body mass and muscle growth. It has been observed to increase energy expenditure and boost fat loss, making it a valuable tool for participants seeking to improve their body composition. However, more studies are needed to justify this effect.

Additionally, laboratory research has indicated that HGH fragment 176-191 may have implications for connective tissue regeneration and cartilage growth. Its ability to promote cell proliferation and facilitate cartilage healing suggests its potential use in therapeutic interventions for conditions such as osteoarthritis.


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