Hydrafinil, commonly known as Hydrafinil 9 fluorenol or Fluorenol, is an intriguing alcohol derivative of fluorene. Specifically, it refers to the hydroxy group present on the carbon bridge connecting the two benzene rings of fluoren-9-ol, also known as 9-hydroxyfluorene. This most significant isomer, possessing a white or cream-colored solid state at room temperature, holds significant importance in the realm of research. [R]

Renowned for its synthetic composition, Hydrafinil falls into the category of novel eugeroic nootropic chemicals. This classification points to its possibility to heighten wakefulness and enhance alertness or focus in subjects [R]. Also, the chemical is known for potentially crossing the blood-brain barrier, which means it may change how the brain works. Researchers in many fields are interested in Hydrafinil because it may improve memory, attention, and brain function. In the parts that follow, we’ll talk more about the interesting research that has been done on this powerful compound.

Remember that, despite Hydrafinil’s promise, Hydrafinil is intended solely for research and not for human consumption. Therefore, let’s learn more about Hydrafinil by examining how it operates, what it does, and how it may be utilized in scientific research.

Key Features Hydrafinil powder

RCD.Bio offers Hydrafinil powder with the following specifications:

  • A purity of 98%, verified by third-party laboratory testing.
  • Available in powder form: 1g


  • CAS Number: 1689-64-1
  • Molar Mass: 182.22 g/mol
  • Chemical Formula: C13H10O
  • IUPAC Name: 9H-Fluoren-9-ol
  • Synonyms: Fluorenol 

How Hydrafinil Works?

Hydrafinil, an experimental compound, operates through several mechanisms to potentially enhance cognitive functions. By understanding its mode of action, we can gain insights into the potential benefits it may offer. Here’s a breakdown of how Hydrafinil works: [R]

Modulation of GABA

If Hydrafinil works the same way as modafinil, it is important to remember that it may affect GABA signaling. Modafinil may lower GABA levels in some parts of the brain, like the posterior hypothalamus and the middle preoptic area.  These results could make you more alert and raise your histamine levels.

Altered Neuroelectrical Patterns

It is known that compounds like modafinil decrease slow brain waves (like delta waves) in order to have an impact on neuroelectrical activity. These neuroelectrical changes could be a side effect of higher neurophysiologic stimulating effects.  In other words, neurotransmission to promote wakefulness and sympathetic tone may have increased, and this has resulted in a decrease in the delta band on an EEG.

Increase in Orexin

Orexin is a neuropeptide that may control wakefulness; at high levels, making the feeling of awake and aware. Increased levels of orexin may be one way that Hydrafinil changes neurochemistry and improves vigilance.  Other stimulatory neurotransmitters like dopamine and norepinephrine may also be increased by orexin.

Dopamine Reuptake Inhibitor

Even though Hydrafinil only has a small effect on dopamine absorption, it may still cause a slight rise in the amount of dopamine outside of cells. Increasing dopamine has been linked to better thinking abilities. But it’s important to remember that the dopaminergic pleasure you get from stronger dopamine reuptake inhibitors probably won’t be as strong with Hydrafinil.

Increase in Glutamate

As was already established, glutamate concentrations rise as a result of antagonism of 5-HT6 receptors, an excitatory neurotransmitter. Low quantities of glutamate interfere with learning and memory functions, whereas glutamatergic neurons are functioning at their peak.  It’s likely that Hydrafinil’s impacts on cognition may be brought on by an increase in glutamatergic activity.

Histamine Production

Modafinil and other eugeroics are known to raise histamine levels in the hypothalamus. The circadian clock and sleep/wake cycles are significantly influenced by histamine.  It’s probable that Hydrafinil will raise histamine levels in the hypothalamus as well, which may cause some users to have allergy-like symptoms (such as itchy skin).

5-HT6 antagonist

Hydrafinil works as a blocker on the 5-HT6 receptors. This is a very important part of mending cognitive problems caused by some situations. Hydrafinil is thought to raise the amounts of glutamate and choline in many parts of the brain by blocking these receptors. It could also increase the amount of dopamine and norepinephrine in the brain, especially in the prefrontal region.

Serotonin modulation

Hydrafinil is thought to have a higher affinity for 5-HT6 receptors than similar drugs, which results in serotonin regulation. This could make it easier for more serotonin to build up within the synapses, which could have effects on how someone feels.  It is believed that the serotonergic effects of Hydrafinil only slightly elevate mood.

Increase in Norepinephrine

Although it remains unclear if Hydrafinil functions as a norepinephrine reuptake inhibitor or affects the norepinephrine transporter (NET), it is known to elevate norepinephrine levels in the prefrontal cortex. Increased norepinephrine levels have been associated with improved alertness and cognitive function.

The scientific basis behind the benefits of Hydrafinil

Several clinical research studies have been conducted on Hydrafinil to find out how it can help the human body. Here are some examples of Hydrafinil’s potential applications:

Mood-Enhancing Powers of Hydrafinil

Hydrafinil is an intriguing compound that has been reported to have a possible mood-elevating effect, leaving many curious about how it works.

Studies have shown that by possibly increasing dopamine and serotonin levels in the brain, Hydrafinil has the potential to boost mood. Higher serotonin levels have been linked to improved memory and enhanced learning speed, allowing individuals to process information more efficiently. Moreover, increased dopamine levels have been associated with reduced mental fog and a greater enjoyment of life. [R] [R]

Reduction of Daytime Fatigue

Hydrafinil may also potentially help people feel less tired during the day and reduce brain fog, which is a big plus. Researchers have found that this chemical could possibly initiate feelings of less tiredness and clearing the mind. It may also help remember things better [R]

Hydrafinil may have positive effects on cognitive function, especially when it comes to improving logical thinking and making it easier to understand information while awake. 

It is important to note that Hydrafinil should not be promoted for human use, as its safety and efficacy for such purposes have not been thoroughly studied. 

Promotion of Wakefulness

Hydrafinil may effectively promote wakefulness and enhance mental alertness, mainly due to its impact on dopamine levels [R]. By potentially influencing dopamine, a neurotransmitter associated with motivation and reward, Hydrafinil may help to stay awake and maintain a heightened state of mental alertness.

Hydrafinil may increase alertness, but it may also help in paying attention to not getting distracted or sleepy as often. This can be especially helpful when focus is needed for a longer time.

However, it is important to emphasize that Hydrafinil should not be promoted for human use. More study is needed to fully understand how it works.

Improve Sleep-Wake Cycles and Neuroprotection

Hydrafinil may be similar to modafinil, as a result, Hydrafinil may promote sleep schedule, which can improve overall health. Furthermore, research evidence demonstrates the importance of sleep for brain health, suggesting that Hydrafinil may provide some form of neuroprotection. [R]

However, no human trials have been conducted to investigate these effects and benefits. This means that Hydrafinil needs more research before it can be adapted for human consumption.


Although Hydrafinil may provide several benefits, this chemical is still undergoing research making it very unsafe for human consumption.

But it’s crucial to remember that Hydrafinil hasn’t been thoroughly investigated, and neither its safety nor its effectiveness have been confirmed. What is written here is for educational purposes only.

Potential side effects

Even if they are not severe, especially in comparison to Modafinil, the adverse effects should be acknowledged. Although less so than other comparable medications, Hydrafinil nevertheless has the potential to interfere with sleep and increase anxiety. Headaches, nausea, nervousness, and dizziness are frequent adverse effects. [R

Where can I Buy Hydrafinil? offers  Hydrafinil is a research compound for laboratory research use only.

When buying Hydrafinil, it is important to choose a reputable seller who provides affordable quality products. is a reliable source that provides Hydrafinil specifically for laboratory research use only.

At, we understand the importance of drug quality and transparency. That’s why we ensure that every Hydrafinil purchase is accompanied by a Certificate of Analysis, which is issued by a third party. This certificate verifies the identification, purity, and concentration of our Hydrafinil product, giving you confidence in the integrity of your research materials.


In conclusion, Hydrafinil, also known as 9-fluorenol, is a synthetic compound with potential eugeroic properties, promoting wakefulness and alertness. Its mechanism of action involves various factors such as receptor antagonism, neurotransmitter modulation, and effects on neuroelectrical patterns and orexin levels. However, there is still much to be understood about the specific workings of Hydrafinil, necessitating further research.

While Hydrafinil has been suggested to have mood-enhancing, fatigue-reducing, and sleep-wake cycle-improving effects, these claims remain to be substantiated through additional investigation. It is crucial to note that the safety and efficacy of hydrafinil have not been thoroughly established, and there may be potential side effects including sleep disturbances, increased anxiety, headaches, nausea, nervousness, and dizziness. Consequently, this compound is strictly intended for research purposes and should not be used without adequate scientific evidence.


Please take note of the scientific applications of this product and carefully read our Terms and Conditions before making a purchase from By completing your order and submitting payment, you agree to abide by our Terms and Conditions. Please be aware that the product packaging may differ slightly from the images displayed on our website.

If for any reason you are not completely satisfied with the product you receive, please contact us at [email protected]. Our team is dedicated to ensuring customer satisfaction and will be happy to assist you.

PLEASE NOTE: All products offered by are strictly intended for laboratory and research purposes only. They are not intended for use on animals or humans.