Introduction

There is a compound in the scientific community that has stirred up the interest of researchers trying to understand how growth, differentiation, and cell signaling work. The chemical name for this substance is LR3 Insulin-like Growth Factor-1. IGF-1 LR3 has the potential to greatly advance our understanding of cellular processes due to its unusual structure and wide range of roles.

IGF-1 LR3 is a peptide composed of 70 amino acid sequences and has a molecular weight of 7.6 kDa. What sets it apart is its striking resemblance to insulin, enabling it to bind not only to its receptor, IGF-1R but also to the insulin receptor, albeit with a slightly lower affinity. It is crucial to note that IGF-1 LR3 is strictly a research chemical and any discussions regarding its use in humans are beyond the scope of this article. As the principal mediator of growth hormone (GH), IGF-1 LR3 plays a pivotal role in promoting and regulating cell growth, differentiation, and anabolic effects in adult organisms. Its tertiary structure, supported by three disulfide bridges, facilitates optimal binding to the IGF-1R, initiating crucial cellular processes necessary for development and maintenance. [R]

IGF-1 LR3 is not a solitary entity but exists in three distinct isoforms: IGF-1Ea, IGF-1Eb, and IGF-1Ec. These isoforms differ in the E domain of the peptide at the C terminus. Of particular interest is IGF-1Ec, also known as mechano-growth factor (MGF), which exhibits remarkable sensitivity to mechanical forces. Additionally, IGF-1Ec acts as a vital regenerative factor by activating stem cells. Its unique characteristics make it an intriguing subject for researchers aiming to unravel novel mechanisms of tissue repair and regeneration. [R]

Key Features of  IGF-1 LR3

RCD.Bio offers IGF-1 LR3 with the following specifications:

  • A purity of 98%, verified by third-party laboratory testing.
  • Available in Media Grade Peptide and Receptor Grade Peptide Form: 0.1mg / 1mg

How IGF-1 LR3 Works?

IGF-1, or insulin-like growth factor 1, plays a crucial role in healing tendons. When tendons are injured, growth factors are released, including IGF-1. IGF-1 has various effects that aid in the healing process. It stimulates the synthesis of DNA and collagen, which are essential for tendon growth and repair. It promotes the growth of new blood vessels and attracts cells to the injured area. IGF-1 activates specific signaling pathways when it binds to its receptor. IGF-1 has been found to support their differentiation into tendon-like cells. Furthermore, in vivo studies conducted on animals and humans have shown promising results in using IGF-1 for tendon healing. This includes the use of platelet-rich plasma (PRP), which contains IGF-1. Overall, IGF-1 acts as an anabolic factor, stimulating tendon growth and aiding in the repair process. [R]

Additionally, when growth hormone (GH) is produced by the anterior pituitary gland and released into the bloodstream, it triggers the production and release of IGF-1 (insulin-like growth factor 1). IGF-1 then attaches to a receptor called IGF-1R, which is present on the surface of almost every cell in the body. The IGF-1R is made up of two alpha and two beta subunits connected by chemical bonds. The beta subunits have regions inside the cell that can activate when IGF-1 binds to the alpha subunits on the outside of the cell. This activation of the subunits leads to the initiation of several signaling pathways, including the PI3K/Akt pathway and the Raf/MEK/ERK cascade. These pathways help prevent cell death (apoptosis) and promote cell growth and survival. 

IGF-1 and its receptor IGF-1R are crucial for maintaining the balance of healthy tissues in the body. However, they can also have negative effects on diseases like cancer, where they can support the survival and rapid growth of cancerous cells. IGF-1 is primarily produced by the liver and travels through the bloodstream to reach target tissues. It is also produced by other tissues in the body, where it acts locally and has a more direct influence on neighboring cells (paracrine effect). In certain cases, IGF-1 can play an autocrine role in cancer, meaning cancer cells can produce and respond to IGF-1, promoting their own growth and survival. [R]

The scientific basis behind the benefits of IGF-1 LR3

Numerous research investigations and trials on animals suggest that IGF-1 LR3 may have several benefits. 

IGF-1 and Wound Healing

In the process of wound healing, the role of natural insulin-like growth factor-1 (IGF-1) is known, but the effects of giving IGF-1 externally for wound repair are not well understood. Additionally, the relationship between IGF-1 receptor (IGF-1R) and estrogen receptors (ERs) in the context of skin repair has not been explored. This study investigated the effects of locally administered IGF-1 in an animal model of estrogen deprivation (ovariectomized mice) and found that it may potentially initiate wound repair primarily by reducing local inflammation and enhancing re-epithelialization. [R]

However, further research is necessary to understand the effects of IGF-1 in wound healing and estrogen deficiency. 

IGF-1 LR3 Fat Metabolism and  Diabetes

Since IGF-1 LR3 binds to both the insulin and IGF 1R receptors, it may play a secondary role in fat metabolism in addition to its role in reducing blood sugar levels. Increased uptake of glucose from the blood by muscle, liver, and nerve cells may contribute to a reduction in blood sugar levels as a result of this interaction.[R]  According to research published in 2013, this drop in blood sugar may cause glycogen and triglyceride breakdown in adipose tissue and the liver. Consequently, there may be less adipose tissue and higher net energy expenditure.[R]

These findings suggest that IGF-1 LR3, as a derivative of insulin-like growth factor, holds promise as a treatment option for reducing insulin requirements in individuals with type 2 diabetes. By utilizing its effects on blood sugar regulation and fat metabolism, it could potentially offer therapeutic benefits to diabetes patients.[R]

However, it is important to note that despite the potential health advantages, further in-depth and large-scale clinical trials are necessary to fully understand the efficacy and safety of IGF binding proteins. Rigorous research is vital in order to establish the precise mechanisms of action, potential side effects, and long-term effects of this research chemical.

IGF-1 LR3 and  Myostatin

Myostatin, or growth differentiation factor 8 (GDF-8), is a protein found in skeletal muscle that blocks the development and differentiation of new muscle fibers.[R] Mouse models of Duchenne muscular dystrophy (DMD) have shown, however, that IGF-1 LR3 and other IGF-1 derivatives can inhibit myostatin’s destructive effects. They aid in protecting muscle cells from damage and apoptosis. MyoD activation is central to the mechanism by which IGF-1 LR3 inhibits myostatin. Myostatin inhibits muscle growth and differentiation, but this activation appears to play a significant role in overcoming this inhibition.[R]

These findings have sparked interest and excitement within the scientific community, as they suggest the potential applications of IGF-1 LR3 in conditions characterized by muscle wasting, such as DMD. By counteracting the effects of myostatin and activating MyoD, IGF-1 LR3 may offer a promising avenue for preserving and promoting muscle health. However, it is important to note that further research is required to fully understand the intricate mechanisms involved in the interaction between IGF-1 LR3, myostatin, and Muscle protein called MyoD. 

IGF-1 LR3 and Cell Division

IGF-1 LR3, similar to IGF-1, possesses the potential to stimulate cell division and proliferation. While its primary effects are thought to target connective tissues such as muscles and bones, it has also been found as most potent growth factor as it potentially promotes cell division in various other organs and tissues, including the kidneys, liver, skin, nerves, lungs, and blood tissues.[R]

It is crucial to understand that scientific studies suggest that IGF-1 LR3, along with all other derivatives of IGF-1, does not primarily promote cell enlargement, but rather focuses on promoting cell division and proliferation. Let’s take the example of muscle cells. Instead of causing muscle cells to grow and enlarge in size, IGF-1 LR3 may actually increase the total number of muscle cells.[R]

This particular aspect of IGF-1 LR3 highlights the need for further research and investigation. Scientists and researchers are continuously working to unravel the intricacies of how IGF-1 LR3 functions and its specific impact on various types of cells. By gaining a deeper understanding of this peptide’s mechanism of action, we can potentially harness its benefits in a more targeted and effective manner.

Precautions

The information presented here is for educational purposes only and should not be construed as medical advice. IGF-1 LR3 is intended for laboratory research use only and is not intended for human consumption.

Potential side effects

IGF-1 LR3 may cause the growth of mucosa inside the intestines, potentially affecting the small intestine. [R]Other reported side effects include swelling in the retina, severe muscle and joint pain, Bell’s palsy (facial weakness), and a potential association with certain cancers (breast, colon, lung, and prostate). [R]

Where Can I Buy  IGF-1 LR3 Online?

RCD.bio offers  IGF-1 LR3  for laboratory and research use only.

When buying  IGF-1 LR3, it is important to choose a reputable seller who provides quality  IGF-1 LR3. At RCD.bio, each product is accompanied by a third-party-issued Certificate of Analysis showing the identification, purity, and concentration of our product.

Conclusion

GF-1 LR3 is a potent growth factor found in the scientific community that holds tremendous promise for advancing our understanding of cellular processes, growth regulation, and tissue repair. Resembling insulin, this compound plays a crucial role in promoting cell growth and regulating anabolic effects. IGF-1 LR3 exists in different isoforms, including IGF-1Ec, which exhibits unique regenerative properties. Research suggests that IGF-1 LR3 may aid in wound healing, fat metabolism, and muscle preservation by inhibiting myostatin. Additionally, it has the potential to stimulate cell division in various organs and tissues. However, further research is necessary to fully comprehend the intricate mechanisms involved and ensure the safety of this potent growth factor.

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