Indole-3-carbinol is a sulfur-containing compound found in cruciferous vegetables like cabbage, broccoli, and cauliflower. It’s derived from glucobrassicin, which is naturally present in these vegetables and is produced when they are chopped, chewed, or cooked. Additionally, synthetic forms of indole-3-carbinol are available.

One of the alleged benefits associated with indole-3-carbinol is its ability to promote proper detoxification processes in the body. It is believed to assist in the removal of toxins and harmful substances. This compound may also contribute to creating a less acidic stomach environment, potentially reducing the risk of certain digestive issues.

Furthermore, indole-3-carbinol is known for its capacity to neutralize free radicals. This antioxidant property may help protect cells from oxidative damage, potentially lowering the risk of various diseases, including cancer. Some studies have suggested that indole-3-carbinol may have a role in cancer prevention, especially in relation to hormone-related cancers.

Additionally, indole-3-carbinol may have a positive impact on reproductive organs, particularly in females. It is thought to help balance hormone levels, potentially reducing the risk of conditions affecting the breasts, uterus, and other reproductive organs.

While these potential benefits of indole-3-carbinol are promising, it’s important to emphasize that more research is needed to establish its efficacy definitively. Always consult with a healthcare professional before adding any compounds like indole-3-carbinol to your research studies.

Indole 3 Carbinol Product Details

Indole-3-carbinol (I3C), a sulfur-containing compound readily converted from glucobrassicin found in gluten-free vegetables like cabbage, broccoli, and cauliflower, stands out as a uniquely abundant and essential component for promoting detoxification support and maintaining cellular health.

Within the acidic stomach environment, I3C undergoes transformation, giving rise to biologically active compounds such as 3,3′-diindolylmethane (DIM) and 5,11-dihydroindolo-[3,2-b]carbazole (ICZ). These molecules play a vital role in neutralizing free radicals and influencing biotransformation enzymes, which are critical for metabolizing a wide range of biologically active substances, including hormones, drugs, carcinogens, and toxins.

I3C and DIM have demonstrated the ability to modulate the expression and activity of these enzymes, potentially reducing the risk of hormone-dependent cancers. While their precise impact on breast cancer risk remains unclear, preclinical studies suggest that they influence multiple signaling pathways relevant to cancer cell behaviors.

However, it’s important to note that further randomized controlled trials are needed to establish the full benefits of I3C supplementation in these contexts. This compound is not the best substitute for any specific medical condition.

Today, you can find various Indole-3-Carbinol products on the market, some offering 200 mg 60 veg capsules, and others specifically catering to vegans, ensuring they are free from tree nut ingredients.

Key Features

  • 98% Product Purity
  • Sold for research purposes only

Potential Benefits of Indole 3 Carbinol for Sale

Cancer Risk Reduction

Epidemiologic studies have linked cruciferous vegetable diets, the primary source of I3C, to a lower risk of cancer. Preclinical research suggests that I3C may be effective against a variety of cancers, including those affecting the breast and other reproductive organs. Multiple preclinical studies have shown that I3C has anti-cancer effects in cell lines and animal models, indicating that it has the potential to be used as a cancer-prevention agent. [R][R][R]

Enhanced Cancer Treatment

Preliminary evidence suggests that I3C may improve the efficacy of certain cancer treatments, such as tamoxifen, doxorubicin, and gemcitabine. This possibility could lead to better cancer treatment outcomes. [R][R][R]

Hormone Regulation

I3C has anti-estrogenic properties and may be involved in hormone-related conditions. Preclinical research suggests that I3C can affect estrogen-related pathways. [R]

Angiogenesis Inhibition

Preclinical research suggests that I3C can influence estrogen-related pathways. I3C has also been shown to inhibit angiogenesis, the formation of new blood vessels that supply nutrients to tumors. This property could be useful in limiting tumor growth. [R][R]

Antimicrobial and Anti-Inflammatory Properties

Antimicrobial and anti-inflammatory properties of I3C may contribute to its overall health benefits. [R][R]

Precancerous Lesion Treatment

I3C has shown promise in clinical trials for the treatment of precancerous conditions such as cervical dysplasia and vulvar intraepithelial neoplasia. Early-stage clinical trials suggest that I3C may be effective against precancerous lesions. [R][R]

Hormone Metabolism Regulation

In premenopausal women, I3C and its active metabolite, DIM, may positively influence estrogen metabolism and hormone-binding globulin levels. This effect has the potential to lower the risk of breast cancer. Randomized controlled trials (RCTs) involving DIM supplementation in tamoxifen-treated breast cancer patients indicate beneficial changes in estrogen metabolism. [R]

While preclinical and early clinical research are promising, the full effects of I3C in humans are not yet fully understood. Some studies indicate potential limitations and drug interactions, and the optimal dosage for achieving its chemo-preventive benefits warrants further investigation.  [R]

Furthermore, recent research suggests that the benefits of cruciferous vegetables, such as I3C, may not necessitate large quantities or high-dose supplements. A well-balanced diet rich in these vegetables may provide adequate health benefits. More research is needed to confirm these findings and determine I3C’s suitability as a chemopreventive agent in participants.  [R]

How It Works

Indole-3-Carbinol (I3C) operates through a multifaceted mechanism of action within the human body. It is derived from the breakdown of glucobrassicin, a sulfur-containing compound found in cruciferous vegetables, providing a full spectrum of health-protective benefits. This unique compound’s actions encompass epigenetic processes that influence gene expression.

One notable aspect of I3C’s mechanism is its ability to counter immune evasion by viruses like HPV16 by antagonizing crucial protein repression. Additionally, it acts as a histone deacetylase class I inhibitor, which reduces the production of proinflammatory cytokines and moderates T-cell activation.

Regarding hepatoprotective mechanisms, I3C plays a role in modulating the immune response, inhibiting proinflammatory cytokines and chemokines, and impacting microRNAs associated with liver damage.

In the context of cancer cells, I3C displays diverse effects. At higher doses, it induces apoptosis, a process of programmed cell death. At lower doses, it inhibits cell growth. I3C also regulates microRNAs, modulates estrogen receptors, and reduces the expression of enzymes like aromatase, which is involved in estrogen synthesis. However, the precise role of I3C in carcinogenesis remains complex, and further human studies are necessary to fully understand its impact.

It’s worth noting that I3C’s typical instability in the body can lead to the formation of various metabolites, including 3,3′-diindolylmethane (DIM). These metabolites may contribute to its biological effects, and isolated DIM is sometimes used as a supplement to harness specific health benefits.


When researching the use of Indole-3-Carbinol (I3C), it is essential to take certain precautions. Here are some precautions to keep in mind:

Observe best practices for studying research chemicals

Studying research chemicals requires a responsible and informed approach to ensure safety and meaningful scientific exploration. Research chemicals, also known as designer drugs or experimental compounds, are substances synthesized for scientific investigation or exploration of their properties.

Follow the recommended dosage

Adhere to the recommended dosage instructions outlined on the product label. Avoid exceeding the suggested dose to minimize the risk of potential adverse effects among test subjects.

Safety and Side Effects

Indole-3-carbinol (I3C) is generally considered safe when consumed through dietary sources like cruciferous vegetables; however, supplemental forms and higher doses can lead to potential side effects. Some test subjects, particularly those with sensitive stomachs, may experience digestive upset, including nausea and bloating. Additionally, I3C may interact with certain medications, potentially affecting their efficacy.


In conclusion, Indole-3-carbinol (I3C) derived from cruciferous vegetables stands as a promising dietary supplement with potential health benefits. It has been associated with promoting proper detoxification, hormone regulation, and even cancer risk reduction in various research studies. However, it’s important to note that the safety and efficacy of I3C can vary among participants, and sensitive individuals may experience gastrointestinal discomfort when taking supplements at higher doses. Moreover, those taking medication should consult a physician to evaluate potential interactions.

When considering I3C compounds, it’s advisable to carefully review the supplement facts and additional compounds, ensuring they align with your dietary preferences, such as non-GMO and vegetable source ingredients.


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