J147 Powder is a research compound being investigated for its possible benefits for brain cells. It has also shown potential in addressing neurodegenerative disorders, specifically Alzheimer’s disease.

With its optimal molecular weight, J 147 Powder is believed to efficiently cross the blood-brain barrier, allowing it to directly impact brain cells and promote brain health. It exhibits the ability to decrease blood glucose levels, indicating potential applications in managing conditions like diabetes. Moreover, J147 is thought to influence acetylcholine or phosphodiesterase enzymes, which are essential for cognitive enhancement, leading to potential improvements in memory and cognitive abilities, particularly in individuals with memory deficits. Its targeted modulation of protein interactions and cellular processes holds promise for the prevention or attenuation of neurodegenerative changes associated with Alzheimer’s disease.

J 147, despite the above-mentioned health advantages, is still classified as an experimental drug. This category suggests that the compound is unsafe for human consumption. Buy J147 for research purposes only.

J147 Powder Product Details

J147 is a research compound derived from curcumin, a polyphenol found in turmeric and ginger. Initially developed in 2011, the molecular mechanism of action of J147 has only recently been uncovered. This compound shows promising potential as a potent neuroprotective agent affecting memory enhancement.

Furthermore, J147 holds promise as a preventive treatment for neurodegenerative diseases, which are characterized by the progressive degeneration of brain neurons. This neurotrophic compound has the potential to assist test subjects with Alzheimer’s disease by mitigating the debilitating cognitive decline associated with its progression. Additionally, J147 has been found to have anti-aging properties and can enhance memory.

Despite the numerous benefits demonstrated by J147, further large-scale clinical studies are required to validate these findings.

  • CAS Number 1146963-51-0
  • Molar Mass 350.33g·mol−1
  • Chemical Formula C18H17F3N2O2
  • IUPAC Name N-(2,4-dimethylphenyl)-2,2,2-trifluoro-N-[(E)-(3-methoxyphenyl)methylideneamino]acetamide

Key Features of J147 Powder

  • 98% Purity
  • 500mg
  • Sold for research purposes only

Potential Benefits of J147 Powder

J147 as a Potential Nootropic

J147 exhibits promising properties as a nootropic, capable of reversing severe cognitive deficits even in elderly animal models. It has demonstrated positive effects on spatial memory and long-term potentiation, suggesting its potential in improving memory and learning abilities. [R][R]

J147 and Diabetes

Animal models have demonstrated that J147 can lower blood glucose and HbA1c levels by increasing AMPK. Additionally, although not statistically significant, J147 may improve the function of residual beta cells in diabetes. [R][R]

J147 and Mitochondrial Function

Studies have indicated that J147 can improve mitochondrial function indirectly, leading to increased ATP levels. This compound has shown the ability to mitigate oxidative stress and enhance mitochondrial function, as evidenced by its effect on ATP synthesis (specifically ATP5A inhibition). [R]

J147 as an Anti-Aging Agent

Researchers have suggested that J147 has the potential to rejuvenate aging cells. Mitochondrial dysfunction is known to accelerate the aging process, leading to a decline in cellular homeostasis and physiological activity. J147 has been found to counteract these effects by reducing the production of reactive oxygen species (ROS) and mitigating cell damage and mitochondrial deterioration. [R]

J147 and Diabetic Neuropathy

J147 shows potential in treating diabetic peripheral neuropathy (DPN), a condition characterized by nerve damage due to chronically elevated blood glucose levels. In both in vivo and in vitro studies using rats, J147 dosages have alleviated DPN by negatively regulating AMPK on TRPA1. This compound has been proposed as a non-pharmaceutical alternative to polypharmaceutical approaches for treating the various pathogenic mechanisms contributing to diabetic neuropathy. [R]

J147 and Major Depressive Disorder

Major depressive disorder (MDD) is a severe mental disorder associated with a deficiency of monoamine neurotransmitters, particularly serotonin (5-HT) and its receptors. Studies have shown that acute treatment with J147, a novel curcumin derivative, has exhibited antidepressant-like effects in the hippocampus of mice by increasing brain-derived neurotrophic factor (BDNF) levels. [R][R]

J147 and Alzheimer’s Disease

Laboratory-controlled studies have shown that J147 has the potential in slowing the progression of Alzheimer’s disease and reverse memory loss. It achieves this by modulating neurotrophin signaling, which promotes neuronal survival and enhances memory formation and cognition. Additionally, J147 has been found to increase levels of nerve growth factor and brain-derived neurotrophic factor, which are neurotransmitters that play a crucial role in memory formation, learning, and cognitive functions. [R][R]

How It Works

J147 operates by modulating the body’s natural energy and focus requirements by interacting with the ATP synthase enzyme. This mitochondrial protein plays a crucial role in regulating the aging process by controlling cellular energy production.

The presence of J147 in the human system helps prevent age-related toxicities resulting from mitochondrial dysfunction and excessive ATP production.

In addition to its impact on energy regulation, J147 also influences the levels of various neurotransmitters, including NGF and BDNF. Furthermore, it reduces the elevated levels of beta-amyloid, which are commonly observed in individuals with Alzheimer’s disease and dementia.

The effects of J147 encompass a range of positive outcomes, such as slowing the progression of Alzheimer’s disease, preventing memory loss, and promoting the production of new neuronal cells.


When researching the use of J147 Powder, it is essential to take certain precautions. Here are some precautions to keep in mind:

Observe best practices for studying research chemicals: Studying research chemicals requires a responsible and informed approach to ensure safety and meaningful scientific exploration. Research chemicals, also known as designer drugs or experimental compounds, are substances synthesized for scientific investigation or exploration of their properties.

Follow recommended dosage: Adhere to the recommended dosage instructions outlined on the product label. Avoid exceeding the suggested dose to minimize the risk of potential adverse effects among test subjects.

Safety and Side Effects

J147 has undergone extensive clinical testing conducted by independent laboratories, affirming its long-term safety for use. Notably, it is free from genetically modified organisms (GMOs) and gluten, ensuring a suitable option for a wide range of individuals.

However, it is important to acknowledge that certain side effects have been reported in studies. These may include increased heart rate, elevated blood pressure, insomnia, gastrointestinal discomfort, and in rare cases, kidney failure.


In conclusion, J147 Powder offers a range of potential benefits that make it a promising candidate for various applications, particularly in the treatment of Alzheimer’s disease and cognitive impairment. Through its modulation of brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF), J147 Powder has shown the ability to reverse severe cognitive deficits and improve synaptic plasticity, thereby enhancing memory and cognitive function.

Furthermore, J147 Powder demonstrates orally active properties and the ability to cross the blood-brain barrier, allowing it to directly impact brain cells and promote brain growth. Its potential applications extend beyond Alzheimer’s, as it has shown efficacy in treating other neurodegenerative disorders.

Quality control measures have been implemented to ensure the safety and long-term use of J147 Powder. Extensive animal studies and independent research have demonstrated its effectiveness in generating energy, improving synaptic plasticity, and protecting neurons.

Additionally, J147 Powder has shown potential in decreasing blood glucose levels, suggesting its possible application in treating diabetes. Its positive impact on mental intelligence and longevity further adds to its value for research purposes and potential future developments.


Please take note of the scientific applications of this product and carefully read our Terms and Conditions before making a purchase from By completing your order and submitting payment, you agree to abide by the Terms and Conditions of our company. Please be aware that the product packaging may differ slightly from the images displayed on our website.

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PLEASE NOTE: All products offered by are strictly intended for laboratory and research purposes only. They are not intended for use on animals or humans.