Kanna extract is derived from the succulent plant known as Sceletium tortuosum, native to southern Africa, particularly South Africa. This plant material has been traditionally used by the San and Khoikhoi people in the region for over three centuries.

One of the primary advantages of using Kanna extract is its possibly positive impact on cognitive function. It has been recognized for its ability to potentially enhance focus and mental clarity.

Additionally, Kanna extract may assist in alleviating symptoms of anxiety and depression, making it a potential remedy for those seeking emotional balance.

Kanna Extract Product Details

Kanna Extract is a natural substance derived from the succulent plant known as Sceletium tortuosum, native to Southern Africa.

Kanna extract is typically obtained from the Kanna plant, which can be made as Kanna Powder, which is rich in the major alkaloids. The major alkaloid present in Kanna is responsible for many of its beneficial effects.

One of the key advantages of using Kanna Extract or Kanna powder is its ability to promote possible cognitive function and may increase energy levels. It has been traditionally used by South African communities to chew or brew tea to enhance alertness, focus, and mental clarity.

Moreover, Kanna Extract or Kanna powder is renowned for its stress-relieving properties. It may positively impact mood and relaxation, making it a possible natural remedy for those seeking relief from everyday stresses.

Key Features

  • 98% Purity
  • Available in Tablets and Kanna Powder form
  • Sold for research purposes only
  • This is not a vitamin

Potential Benefits of Kanna Extracts


Kanna has displayed the potential to enhance executive function and cognitive adaptability. A study encompassing healthy test subjects who were supplemented with 25 mg/day of Kanna for 9 weeks reported notable improvements in these cognitive aspects. [R]


Active compounds in Kanna bind to the cholecystokinin-1 receptor, which, upon activation, reduces the sensation of hunger. This implies that Kanna may have the potential to assist participants in curbing overeating. [R]

Historical accounts from the early 1900s mention Kanna’s appetite-suppressing effects. Nevertheless, contemporary studies are scarce and imperative to investigate Kanna’s impact on hunger and appetite regulation. [R]


Traditional medicinal practices and animal investigations have suggested that Kanna may function as a natural analgesic. In a rat study, mesembrine derived from Kanna exhibited slightly lower effectiveness compared to the potent opioid morphine. [R]

Traditional customs involved applying Kanna to alleviate leg pain among hunters and farmers and administering it to pregnant female test subjects to alleviate discomfort. [R]

Kanna’s pain-alleviating properties are associated with the activation of opioid receptors in the brain, akin to endorphins and enkephalins. Importantly, Kanna does not seem to engender addiction, in contrast to prescription opioids. [R]


Mesembrine and complete extracts of Sceletium tortuosum, such as Zembrin, exhibit promise as potential antidepressants. Clinical investigations involving Zembrin have shown enhanced sleep quality and diminished stress levels among participants. [R]

In laboratory experiments conducted with rats, a purified Sceletium tortuosum extract demonstrated antidepressant properties roughly equivalent to half the efficacy of imipramine, a tricyclic antidepressant medication. [R]

Certain psychiatric practitioners in South Africa have reported favorable outcomes in managing dysthymia, and anxiety using Kanna. Kanna’s mode of action parallels that of prescription antidepressants and anti-anxiety medications by augmenting serotonin availability, a neurotransmitter linked to mood regulation. [R]

Laboratory analyses have suggested that a Sceletium tortuosum extract rich in mesembrine could potentially reduce the stress hormone cortisol, implying potential utility for users grappling with elevated stress and high blood pressure.

However, further research is necessary to validate these outcomes in animals and humans.

Alzheimer’s Disease

Alzheimer’s disease is characterized by a substantial decline in cognitive function. Scientists have identified phosphodiesterase 4, abbreviated as PDE4, as a potential target for the development of new Alzheimer’s medications. [R]

Due to its capacity to inhibit PDE4, some researchers speculate that Kanna might have the potential to alleviate initial Alzheimer’s symptoms. However, as of now, there haven’t been any clinical trials conducted to validate whether this theory translates into real-world effectiveness. [R]

How It Works

The mechanism of action of Kanna Extract or Kanna powder involves intricate interactions with neurotransmitters and brain receptors. Principally, it impacts the serotonin system, hindering the reuptake of serotonin—a neurotransmitter linked to mood regulation.

By preventing the rapid reabsorption of serotonin by nerve cells, Kanna Extract sustains heightened serotonin levels in the synaptic cleft, potentially fostering improved mood and diminishing feelings of anxiety and depression.

Additionally, Kanna’s active compounds, notably mesembrine, may stimulate specific opioid receptors in the brain, providing potential pain relief without the addictive qualities associated with conventional opioid medications.

Moreover, some research suggests that Kanna Extract, particularly mesembrine-rich varieties, may lower cortisol, potentially reducing anxiety levels, and promoting relaxation and well-being.

Furthermore, interactions with the cholecystokinin-1 (CCK-1) receptor hint at Kanna’s potential role in hunger sensation reduction, potentially offering implications for appetite control and weight management.


When researching the use of Kanna Extract, it is essential to take certain precautions. Here are some precautions to keep in mind:

Observe best practices for studying research chemicals

Studying research chemicals requires a responsible and informed approach to ensure safety and meaningful scientific exploration. Research chemicals, also known as designer drugs or experimental compounds, are substances synthesized for scientific investigation or exploration of their properties.

Follow the recommended dosage in the warning section

Adhere to the recommended dosage instructions outlined on the product label. Avoid a significant increase of the suggested dose to minimize the risk of potential adverse effects among test subjects.

Potential Side Effects

Kanna Extract is generally considered safe for many people when used in moderation and according to recommended dosages. However, some participants may experience side effects, which can include mild gastrointestinal discomfort such as nausea or stomach upset. Additionally, because Kanna Extract primarily affects serotonin levels, excessive use or high doses may lead to symptoms such as headaches, and dizziness.

It’s essential to exercise caution when combining Kanna Extract with other substances that affect serotonin, such as certain medications, as it may increase the risk of serotonin syndrome, a potentially serious condition.

As with any compound or herbal remedy, it’s advisable to consult with a healthcare professional before using Kanna Extract, especially if you have underlying medical conditions or are taking other medications.


In conclusion, Sceletium tortuosum, commonly known as Kanna, has a rich history as a South African succulent plant used for various purposes by indigenous communities. Whether in its traditional fermented forms like Kanna, channa, or kougoed, or in its modern extract and powder, Kanna has demonstrated its versatility over centuries.

Physical crushing of the plant and the fermentation process are thought to reduce the potentially harmful effects of oxalic acid. From soothing the aching legs of hunters and farmers to alleviating anxiety and stress, Kanna offers a potential sense of calm and relief without hallucinogenic or addictive properties.

In the realm of present modern science, Kanna’s potential benefits shine. Its active compounds show promise in addressing anxiety, depression, and mood enhancement, while also offering pain relief. This natural cure holds the potential to treat insomnia, improve cognitive performance, and contribute to an overall sense of well-being.

As participants seek the highest quality Kanna extracts, powders, and collected plant material, it’s important to buy Kanna online from reputable sources to ensure the purity and quality of the product. With its rich history and the presence of beneficial alkaloids, Kanna continues to be a valuable part of nature’s arsenal for enhancing mental and emotional health.

Whether enjoyed as a tea, powder, or in other forms of preparation, Kanna stands as a testament to the healing power of nature.


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PLEASE NOTE: All products offered by are strictly intended for laboratory and research purposes only. They are not intended for use on animals or humans.