Kava Extract Kavalactones


Welcome to the world of kava extract, a remarkable natural remedy during ancient times derived from the Piper methysticum herb found in the South Pacific Islands. With its origins deeply rooted in traditional practices, kava extract has gained recognition for its potential therapeutic benefits. While we must emphasize that this article is focused solely on its use as a research chemical and not for human consumption, we aim to shed light on the fascinating properties of kava extract.

Derived from the kava plant, this extract is commonly available in the form of tablets or capsules, containing ethanolic or acetonic extracts. At the heart of its composition lies a group of compounds known as kavalactones, or kavapyrones, which are the key psychotropic constituents responsible for its potential effects. [R]

Initially developed as an anti-anxiety remedy, kava extract gradually found its way into the wider market, gaining popularity for its potential in addressing anxiety symptoms. Numerous clinical investigations have suggested that kava extract may indeed be a promising treatment option for anxiety. Additionally, further research has explored its potential in enhancing sleep quality, making it a subject of interest in the field of nootropics.  [R]

However, it is essential to reiterate that the purpose of this article is to inform and educate about kava extract as a research chemical, not to promote its use for human consumption. We encourage responsible and ethical practices when utilizing kava extract solely for scientific research purposes. In the following sections, we will delve deeper into the scientific aspects of kava extract, exploring its potential benefits and shedding light on the ongoing research surrounding this intriguing natural compound.

Key Features of Kava Extract Tabs 70 Kavalactones 

RCD.Bio offers Kava Extract Tabs 70 Kavalactones with the following specifications:

  • A purity of 70%, verified by third-party laboratory testing.
  • Available in 100mg/50ct/5g and 100mg/100ct/10g in tablet form

How Kava Extract Works?

Kava extract is a natural remedy that has gained popularity for its potential benefits in promoting relaxation, reducing anxiety, and providing other health benefits. But how does kava extract actually work? 

Kava extract is believed to exert its pharmacological effects through various mechanisms. One of the key actions of kava extract involves blocking voltage-gated sodium ion channels. These channels play a crucial role in the transmission of electrical signals in nerve cells. By blocking these channels, kava extract may help reduce neuronal excitability, leading to strong feelings of relaxation and sedative effect.

Another pharmacological effects of kava are thought to include in increasing ligand binding to GABA type A receptors, decreasing excitatory neurotransmitter release due to calcium ion channel blockade, reducing noradrenaline (norepinephrine) neuronal reuptake, reversibly inhibiting monoamine oxidase B, and preventing the production of thromboxane A(2). According to reports, it may have sedative, anxiolytic, antistress, analgesic, local anesthetic, anticonvulsant, and neuroprotective qualities due to a blend of chemicals known as kavalactones. [R]

The scientific basis behind the benefits of Kava Extract Kavalactones

Numerous research investigations and trials on animals suggest that kava extract may have a number of benefits. 

Anti-inflammatory Activity

When skin is exposed to UV light, it can lead to inflammation and swelling. However, the study revealed that kava extract may help combat these effects. The natural kavalactones present in kava extract, with a particular focus on kavain, demonstrated their ability to reduce skin inflammation caused by UV light exposure.

Furthermore, kava extract showed promising anti-inflammatory effects against other substances as well. Inflammation induced by formalin, serotonin, carrageenan, or dextran was significantly inhibited by the natural kavalactones found in kava extract. These substances are known to trigger inflammation and swelling in the body.  [R]

Antioxidant activity

Kava extract, derived from the root of the Piper methysticum plant, has been studied for its antioxidant activity. Researchers conducted a study where they examined the properties of the aqueous extract of kava root and isolated ten different fractions containing six flavonoids and seven kavalactones. To evaluate their antioxidant capabilities, they used two commonly used assays called DPPH and ABTS.

The DPPH assay and ABTS assay are methods used to measure the ability of compounds to scavenge free radicals. Free radicals are unstable molecules that can cause damage to cells and contribute to various health problems. Antioxidants, on the other hand, can neutralize these free radicals, reducing their harmful effects.

In the study, one of the isolated compounds from kava extract, called compound C3 or isosakuranetin, demonstrated the most potent antioxidant properties. It showed strong free radical scavenging activity. What this means is that compound C3 from kava extract has the possibility to neutralize free radicals, protecting cells from their damaging effects. By acting as an antioxidant, kava extract may help reduce oxidative stress in the body, which is associated with various health conditions and aging.[R]


Kava root extract has been studied for its potential in treating gout, a type of arthritis caused by high levels of uric acid in the blood. In a study, researchers examined the aqueous extract of kava root and evaluated its anti-hyperuricemia activity using an in vitro assay that measures the inhibition of xanthine oxidase, an enzyme involved in uric acid production. Among the compounds tested, compound C10 (alpinetin) showed the most promising results, displaying a significant inhibitory effect on xanthine oxidase with an IC50 value of 134.52 µg/mL. These findings suggest that kava extract, particularly the compound alpinetin, may have potential as an anti-gout treatment, but further research is needed to explore its effectiveness and safety in humans. [R]


In the same study mentioned earlier, researchers investigated the antibacterial properties of kava root extract. They identified two mixtures of kavalactones, specifically MC5 and a pure compound C6 , which showed the ability to inhibit the growth of Listeria monocytogenes bacteria. Additionally, another kavalactone mixture, MC7 (kavain), demonstrated the potential to restrict the development of Klebsiella pneumoniae bacteria. These findings suggest that kava extract, particularly the identified kavalactones, may possess antibacterial properties that could be further explored for their potential applications in fighting bacterial infections caused by these specific strains.[R]

Anxiety Reduction

A study protocol for a randomised controlled trial has been published for the treatment of generalised anxiety disorder. The traditional extract of kava has been found to help in anxiety. [R]

Furthermore, clinical studies revealed that kava was effective for treating mild to moderate anxiety when taken daily in doses between 20 and 300 mg of kavalactones. [R]

Sleep Improvement

In a trial,  the effectiveness of a specific extract of kava, known as WS 1490, in test subjects experiencing sleep disturbances related to non-psychotic anxiety, tension, and restlessness has been examined.

In conclusion, this study suggests that sleep disturbances associated with non-psychotic anxiety disorders maybe managed using kava extract WS 1490. [R]

Mood and Cognition

In a double-blind randomized placebo-controlled trial involving healthy test subjects, the acute effects of Kava-kava (Piper methysticum G. Forster), on emotional reactivity and cognitive performance were investigated. The study employed several measures to assess mood changes and cognitive performance. Notably, the mood-elevating effects of Kava were most pronounced in test subjects who had a naturally cheerful disposition (trait cheerfulness), suggesting that trait cheerfulness influenced the drug-induced increase in cheerful mood.

Furthermore, Kava was found to possibly improve the accuracy and speed of performance in the partial report and item recognition tasks, indicating its beneficial effects on visual attention and short-term memory retrieval, respectively.  This suggests that Kava has the potential to enhance cognitive functioning.

In conclusion, Kava exhibited potent anxiolytic properties while also facilitating cognitive functioning and promoting positive affectivity associated with exhilaration. [R]


This material is being provided for educational reasons only; it is not intended to be taken as medical advice. Kava product is not meant for human consumption and is only meant for use in laboratories as a research chemical.

Potential side effects

Kava’s potential hepatotoxicity including liver failure has long been documented by using Kava. [R

headaches, dehydration, shakes and jitters, high blood pressure, and heartburn. [R]

Where can I Buy the Best Kava Extract Kavalactones?

RCD.bio offers Kava Extract Kavalactones for the sole reason of using it for laboratory research.

When buying kava extract, it is important to choose a reputable seller who must have provided the highest quality products to regular users in research. At RCD.bio, each product is accompanied by a third-party-issued Certificate of Analysis showing the identification, purity, and concentration of our product.

Some also offer this amazing botanicals such as kava tincture and kava bars


Kava extract from Piper methysticum has been studied for its potential benefits in various areas.
It has shown anti-inflammatory activity, antioxidant properties, and anti-hyperuricemia activity. The antibacterial effects of Kava extract have been observed against certain bacterial strains. Studies have also indicated its possible efficacy in reducing anxiety symptoms and improving sleep quality of well-being. Furthermore, Kava extract has demonstrated mood-enhancing effects and has the potential to enhance cognitive functioning.

It is important to note that the quality and composition of Kava products can vary, and caution should be exercised when using them. Additionally, concerns have been raised regarding the potential hepatotoxicity of Kava, including liver failure. 


Please take note of the scientific applications of this product and carefully read our Terms and Conditions before making a purchase from RCD.bio. By completing your order and submitting payment, you agree to abide by our Terms and Conditions. Please be aware that the product packaging may differ slightly from the images displayed on our website.

If for any reason you are not completely satisfied with the product you receive, please contact us at [email protected]. Our team is dedicated to ensuring customer satisfaction and will be happy to assist you.

PLEASE NOTE: All products offered by RCD.bio are strictly intended for laboratory and research purposes only. They are not intended for use on animals or humans.