L-Tetrahydropalmatine (L-THP) is a synthetically produced potent enantiomer of tetrahydropalmatine, an isoquinoline alkaloid found in several different plant species, including Corydalis. L-THP has been found to possess a potential of a wide range of health benefits, including analgesic properties, anti-inflammatory properties, and powerful anti-addiction properties. It has also been shown to have research potential in promoting a healthy mood and reduce depression-related symptoms induced by stress.

L Tetrahydropalmatine Product Details

As one of the active ingredients in Corydalis extract, L-THP has generated significant interest in the medical community due to its therapeutic potential. However, this claim is based on preliminary human studies which means this chemical is not an approved dietary supplement.

  • CAS Number: 112789-14-2
  • Molar Mass: 295.43 g/mol
  • Chemical Formula: C21H27NO4
  • IUPAC Name: (1R,9S,12S)-12-[(R)-1-methoxyethyl]-1,2,3,4,6,7,8,9,10,11,12,13,14,15,16-tetradecahydro-10,13-dimethyl-5,8-methanobenzo[f]azocin-1-ol
  • Synonyms: Tetrahydropalmatine L-THP powder, L-tetrahydropalmatine, L-THP, Stephania tetrandra, and (R)-1-[(1S,3aR,4S,6aR)-4-(benzoyloxy)-1,2,3,3a,4,5,6,6a-octahydro-1,3a,5-trimethyl-1H-benzimidazol-1-yl]ethan-1-ol

Key Features L-THP

  • 98% purity
  • 10g
  • Being studied for its potential anti-addiction property
  • Sold for research purposes only

Possible Benefits of L Tetrahydropalmatine L THP

L-Tetrahydropalmatine for Pain Relief

L-Tetrahydropalmatine (L-THP) as a possible adrenergic agent, along with its alleged analgesic properties, promotes relief for pain. It has been shown to possess analgesic features to decrease pain caused by acidosis by inhibiting the activity of acid-sensing ion channels in rat DRG neurons. [R]

In mice, L-THP research compounds have been observed to produce analgesic effects via D1R agonist and D2R antagonism, resulting in increased mechanical threshold, thermal latency, and non-rapid eye movement sleep. [R]

The berberine alkaloid found in L-THP can also produce anti-hyperalgesia effects by intensifying dopaminergic transmission through D1R. [R]

L-Tetrahydropalmatine (L-THP) for Addiction

L-THP may also have anti-addiction properties, as it has been found to block the effects of methamphetamine (METH) in all stages of the conditional place preference (CPP) task. It has also been observed to selectively activate critical regions of the brain’s dopaminergic, serotonergic, and norepinephrine systems according to pharmacological magnetic resonance imaging. [R] [R] [R]

L-THP can inhibit morphine-induced CPP acquisition and expression in a dose-dependent manner. [R] [R] [R]

L-Tetrahydropalmatine and Cardiovascular Health

One research study claims that L-THP promotes cardiovascular health by activating the KATP channel, which can encourage angiogenesis by regulating the sequence of citrulline-to-arginine flux, arginine biosynthesis, and VEGFR2 expression in endothelial cells. However, further studies are needed to fully understand its potential as a heart health compounds. It is important to note that L-THP is not recommended as a safe food supplement for human consumption and should only be used for research studies. [R] [R]

Overall, it’s important to note that L-Tetrahydropalmatine is a research compound and is not intended for human consumption or as a treatment for any medical conditions. While there is promising research on the potential benefits of L-THP, more studies are needed before any conclusions can be drawn. If you’re interested in studying L-THP, it’s essential to use it only for research purposes and to follow proper safety protocols.

How It Works

L-Tetrahydropalmatine (L-THP) is a potent enantiomer of the tetrahydroprotoberberine isoquinoline alkaloid obtained from several different plant species, including Corydalis yanhusuo. L-THP exerts its analgesic properties by acting as a dopaminergic antagonist, particularly at the D1 receptor. This results in a reduction in dopamine release, which can help to alleviate pain and reduce addiction-related behavior.

In addition to its analgesic properties, L-THP has potential anti-inflammatory effects, which may be beneficial in controlling addiction and depression-related symptoms induced by chronic pain. L-THP’s potent anti-addiction properties are thought to be due to its ability to regulate the brain’s reward pathway by inhibiting dopamine release.

Furthermore, L-THP is a heterotetracyclic compound with a unique chemical structure that may contribute to its therapeutic benefits. Scientific studies have shown that L-THP may promote a healthy mood and could improve cognitive function, in addition to its analgesic and anti-addiction properties.

Overall, L-THP’s mechanism of action is complex and multifaceted, involving its ability to act as a dopaminergic antagonist, regulate the brain’s reward pathway, and possess anti-inflammatory properties. The scientific basis behind the benefits of L-THP suggests that this compound may hold promise as a potential treatment for pain, addiction, and other related conditions.


L-Tetrahydropalmatine (L-THP) is a research chemical and is not intended for human consumption. It should only be purchased by authorized personnel who are conducting scientific studies or research. It is important to note that L-Tetrahydropalmatine is marketed worldwide and should be obtained from a reputable supplier that provides lab-tested products.

Potential Side Effects

At higher doses, L-Tetrahydropalmatine (L-THP) may cause side effects such as sleepiness, dizziness, and nausea. In rare cases, it may also lead to respiratory inhibition and extrapyramidal symptoms. It is important to note that the safety and potential side effects of L-THP are still being studied, and more research is needed to fully understand its effects on the body.


In conclusion, L-Tetrahydropalmatine (L-THP) is a potent active compound found in several different plant species, including the Corydalis extract. This heterotetracyclic compound obtained from L-THP has significant analgesic and anti-inflammatory properties and has generated promising results in research studies.

Because L-THP is categorized as a research chemical, buy L Tetrahydropalmatine for research purposes only.


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