You may be familiar with LGD 4033 Ligandrol if you talk about body fat and muscle strength. It’s a research substance that has drawn a lot of attention for its capacity to increase lean muscle mass and decrease body fat mass without having the negative effects of anabolic activity. However, what precisely is LGD 4033 Ligandrol, and is its use safe? The information provided below gives a general description of LGD 4033 Ligandrol. 

It’s important to keep in mind that LGD 4033 Ligandrol, along with other research compounds, is intended only for research purposes and not for human consumption. offers this product only for sale for research use and does not endorse or recommend it for any other purpose. If you are using this product for research, be sure to follow all handling instructions and safety precautions.

What is LGD 4033 Ligandrol?

A selective androgen receptor modulator (SARM) called LGD 4033 Ligandrol was created to treat muscle-wasting diseases like osteoporosis and muscular dystrophy. It functions by attaching to androgen receptors within the body, which aids in gaining strength and muscle growth. (R) (R)

Additionally, LGD 4033 Ligandrol has a selective action, which means that it only targets specific lean body mass tissues like muscle gains while not affecting other tissues like the liver and prostate. (R)

Here is the chemical composition of LGD 4033 Ligandrol: (R)

  • Product Type:  Powder
  • Product Name:  LGD 4033 Ligandrol
  • Application: Scientific
  • CAS: 1165910-22-4
  • Molar Mass: 338.253 g·mol−1
  • Chemical Formula:  C14H12F6N2O
  • IUPAC Name: 4-[(2R)-2-[(1R)-2,2,2-trifluoro-1-hydroxyethyl]pyrrolidin-1-yl]-2-(trifluoromethyl)benzonitrile
  • Synonyms:  VK5211; LGD-4033
  • Storage: Minimize open-air exposure, store in a cool dry place
  • Variants: LGD 4033 Ligandrol Powder (1000mg) and Liquid 30ml/ 15mg per ml/ 450 mg

How Does LGD 4033 Ligandrol Work?

Ligandrol LGD 4033 or selective androgen receptor modulator (SARM) functions by attaching to the body’s androgen receptors, which are located in a few tissues like the muscles, bones, and liver. The activation of these receptors by LGD 4033 Ligandrol after it binds to them causes an increase in muscle protein synthesis, which promotes the development of new muscle tissue. (R)

Ligandrol has been demonstrated to increase bone density by encouraging the growth of new bone tissue in addition to increasing muscle growth. As a result, it has the potential for treatment of ailments like osteoporosis. (R)

What are the Potential Applications of LGD 4033 Ligandrol?

Muscle wasting

LGD 4033 powder works well to prevent potential diseases that cause muscle wasting, like sarcopenia and muscular dystrophy.

A clinical study reported by Yarrow et al. entitled “A Randomized Trial of LGD 4033 Ligandrol in Cachexia and Sarcopenia” was conducted. According to this study, LGD 4033 Ligandrol increased muscle tissues and strength in elderly sarcopenic patients. (R)

Bone health

Research has indicated that LGD 4033 powder can increase bone density and stop bone resorption, making it a potential treatment for diseases like osteoporosis.

Study on rats with orchidectomies: Singh et al.’s “LGD 4033 Ligandrol prevent bone loss in orchidectomized rats” This study demonstrated in osteopenic female rats that the commonly used model for studying osteoporosis, LGD 4033 Ligandrol, prevented bone loss in rats. (R)

Athletic Performance

LGD 4033 powder is the potential for good physical ability because studies have shown that it enhances athletic performance.

A clinical trial conducted by Bhasin et al. entitled “The Effects of LG 4033 Ligandrol on Physical Function and Performance in Healthy Older Men and Women” was conducted. According to this study, LG 4033 Ligandrol enhanced physical performance and function in older adults as test subjects. (R)

Cancer Cachexia

Ligandrol LGD 4033 powder has been researched as a possible treatment for cancer cachexia, a condition that causes cancer patients to lose weight and muscle mass.

The effects of LGD 4033 on muscle wasting in patients with cancer cachexia: a randomized, double-blind, placebo-controlled trial” by Condorelli et al. According to the clinical trial reported, LGD 4033 increased muscle mass and strength in cachectic cancer patients. (R)

Safety and Side Effects

  • Testosterone suppression: LGD 4033 Ligandrol can suppress testosterone production in the body, which can lead to side effects such as decreased libido, fatigue, and muscle weakness. (R)
  • Liver toxicity: LGD 4033 Ligandrol has been shown to cause liver damage in some animal studies. However, the extent of its effects on human liver function is not yet fully understood. (R)
  • Cardiovascular effects: LGD 4033 Ligandrol may cause an increase in blood pressure and other cardiovascular effects, although the evidence for this is limited. (R)
  • Other potential side effects: Other potential side effects of LGD 4033 Ligandrol include headaches, nausea, and mood changes. (R)

In addition, LGD 4033 Ligandrol is currently not approved for human use by the FDA, which means that it’s only available as a research chemical. It’s important to use caution when purchasing LGD 4033 powder and only buys from reputable sources like


Because LGD 4033, selective androgen receptor modulator (SARM) is still a research compound, there are a variety of potential areas for further investigation that could aid in our understanding of its physiological effects and potential applications. Future studies may focus on topics like long-term safety, particular applications, combination therapies, and mechanisms of action.

Overall, there are a lot of potential directions for future study that could aid in our understanding of LGD 4033 effects and potential uses. As research advances, we might be able to better comprehend its effectiveness and safety and tailor its use to various conditions. (R)

What are some of the most promising findings from research on LGD 4033?

Some of the most promising findings from research on LGD 4033 Ligandrol include its potential to increase muscle mass and strength, improve bone density, and reduce muscle wasting in certain conditions.

What types of research studies have been conducted on LGD 4033?

Research studies on LGD 4033 have included animal studies, human trials, and in vitro studies examining its effects on various tissues and pathways.

What are some of the limitations of current research on LGD 4033?

Limitations of current laboratory research use on LGD 4033 include small sample sizes in some studies, short-term follow-up periods, and a lack of long-term safety data.

What are some potential areas of future research on LGD 4033?

Potential areas of future laboratory research on LGD 4033 include further exploration of its effects on specific types of muscle and bone disorders, combination therapies, and examination of its effects on different tissues and pathways in the body.

What are the regulatory considerations for researching LGD 4033 Ligandrol?

LGD 4033 Ligandrol is still a research compound and has not been approved for human use by regulatory agencies such as the FDA. Researchers must comply with ethical and safety guidelines in conducting studies with the compound.

How can researchers access LGD 4033 Ligandrol for use in studies?

LGD 4033 Ligandrol can be obtained from a variety of research chemical suppliers, but researchers should ensure that they are obtaining the compound from a reputable source and complying with all regulatory requirements for its use in research.

Where to Buy LGD 4033 Ligandrol?

When it comes to Nootropics and other research compounds is among the most reliable and novel companies available. We offer targeted solutions with lab-tested purity for your specific needs.


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