Melanotan II (MTII) has a history that goes back to the early 1900s, when the main function of alpha-melanocyte-stimulating hormone (MSH) was figured out in animals, first in frogs and lizards. The hormone’s role in potentially controlling skin color in humans was only recently found. It’s only been in the last few decades that the many functions of MSH and related melanocortins (MCs) were fully understood, such as their role in controlling sexual function in humans. Around 1984, Melanotan I (MTI), a very strong melanotropic peptide, was made so that it could be sold as a tanning agent. Notably, a smaller molecule called Melanotan II (MTII) was created later. It has a structure that is restricted in shape and is more attractive to fat. During testing, an unplanned but important discovery happened: a higher dose of MTII caused nausea right away, and the erection lasted longer than expected. Soon after, more tests showed that a lower dose caused a reliable erectile response. This showed that MTII might be useful for treating impotence. Because MTII works quickly and seems to work well, it is an important new discovery in the field of controlling sexual function and using drugs to potentially help people. [R]
This product was made by RCD.Bio not for people to use, but as a useful tool for researchers who want to learn more about how these compounds work. The goal of RCD.Bio is to help scientists learn more about Melanotan II and its possible uses by giving them a place to search for information. Researchers can use this man-made peptide to find new information, which will help them learn more about how it works in organisms and how it might potentially help sexual problems.
- A purity of 98%, verified by third-party laboratory testing.
- CAS No: 121062-08-6
- Chemical Formula: C50H69N15O9
- Molar Mass: 1024.2 g/mol
- IUPAC Condensed: (3S,6S,9R,12S,15S,23S)-15-[[(2S)-2-acetamidohexanoyl]amino]-9-benzyl-6-[3-(diaminomethylideneamino)propyl]-12-(1H-imidazol-5-ylmethyl)-3-(1H-indol-3-ylmethyl)-2,5,8,11,14,17-hexaoxo-1,4,7,10,13,18-hexazacyclotricosane-23-carboxamide
How does Melanotan-2 Work?
The impact of Melanotan 2 (MT-II) on penile erection is mediated by its interaction with central nervous system melanocortinergic (MC) receptors. The activation of MC receptors is a key trigger for the intricate physiological process of penile erection, which is largely regulated by the central nervous system. Recent studies suggest that although the MC3 and MC4 receptor subtypes are found in the central nervous system, the MC4R is increasingly being recognized as the principal mediator of erections induced by melanocortin.
As a melanocortin agonist, Melanotan 2 binds to these receptors and triggers a series of physiological reactions that augment or facilitate penile erection. The explicit participation of MC4R in this process indicates its importance as the primary effector. It is worth mentioning that there is evidence suggesting that inhibiting MC3R in the forebrain can increase erections induced by melanocortin may have therapeutic implications. By utilizing this mechanism, which is not reliant on traditional methods that target peripheral vascular tissue, novel avenues are created for centrally mediated treatments of erectile dysfunction and other associated sexual dysfunctions.[R]
The mechanism behind the significant tanning effects of Melanotan I (MT-I) lies in its interaction with melanocortin-1 (MC-1) receptors, predominantly located in peripheral melanocytes within the skin. This interaction triggers a cascade of events leading to substantial skin pigmentation, particularly notable on the face and upper body. These areas, typically exposed to the sun, possess a higher density of melanocytes, contributing to the marked impact of MT-I. [R]Comparatively, Melanotan II (MT-II) presents a related yet distinct avenue. While both MT-I and MT-II target melanocortin receptors. It’s worth noting that MT-II may also induce a pigmentation effect, providing a bridge between the two compounds’ shared and unique physiological impacts.
The scientific basis behind the benefits of Melanotan-2
Numerous research investigations and trials on animals suggest that melanotan ii’s use may have several benefits as tanning nasal sprays, increased pigmentation, etc.
Sexual Health in Men And Women
Researchers recently looked into how Melanotan II (MT2) could potentially help with erectile dysfunction (ED). According to the results, MT2 has the potential to be a big step forward for ED. A penile erection was triggered by MT2 in 17 out of 20 male test subjects even when they weren’t sexually aroused, showing that it works to solve this common problem. Penile rigidity increased significantly, with subjects experiencing an average of 41 minutes at a level of rigidity exceeding 80%. Additionally, participants test subjects have showed higher sexual arousal after the administration of MT2 compared to a placebo, showing that it is a powerful way to improve sexual function. Although some side effects like feeling sick and yawning, the overall results of this study suggest that MT2 may potentially aid ED [R]
Sexual Health Problems in Women
It was recently discovered that melanocortins (MCs) play a key role in controlling sexual functions in both male and female subjects. The research looks into the effects of Melanotan II (MTII), an analog of MC, showing that it can improve sexual function in both men and women by increasing genital arousal and, in men, erectile dysfunction. MTII is different from other drugs that improve sexual performance because it works in a way that other drugs don’t. It works in the brain. This unique method creates a more natural sexual response with few or no unwanted side effects, which is very different from traditional methods. Surprisingly, the sexual-enhancing properties of MTII were found by accident while studying how it and related analogs affect the color of human skin. This added an unexpected dimension to its potential uses in dealing with common sexual health problems.[R]
Researchers did an interesting study on how giving mice Melanotan II (MTII), a melanocortin-3/4 receptor agonist, through the cerebroventricular system affected their insulin sensitivity. They focused on liver and whole-body responses that were not affected by food intake or body weight. A group of male C57Bl/6 mice were given 225 ng of MTII over 24 hours. The control group got distilled water. The findings showed that MTII significantly improved insulin sensitivity in the whole body, showing that it improved glucose clearance in both normal and high insulin levels. Interestingly, this effect was seen without changing insulin’s ability to stop the body from making glucose on its own. In addition, MTII caused Glut4 mRNA expression to rise specifically in skeletal muscle. These results show that MTII’s central stimulation of melanocortin-3/4 receptors has a complex effect on insulin sensitivity. This shows that it could be used as a targeted intervention in addition to its known effect on eating and body weight.[R]
Melanotan-II (MT-II), was tested for its ability to make people tan in a groundbreaking pilot phase-I clinical study. Test subjects got MT-II or saline injections under their skin every other day for two weeks as part of the study. Doses were changed gradually, which showed interesting results. It’s interesting that a complex of stretching and yawning happened at the same time as spontaneous penile erections and lasted for 1–5 hours after MT-II doses. Most importantly, more tanning was seen in the face, upper body, and buttocks a week after MT-II doses were given, proving that it worked very well to tan test subjects. These results give us important information about MT-II’s possible uses as a tanning agent. They also open the door for more research and development in this area. [R]
Further research is imperative to explore the use of MT-II as a tanning product, especially in the form of a tanning nasal spray for sunless tanners. Many individuals resort to tanning beds, which can potentially lead to skin cancers due to the high UV exposure on skin cells. Therefore, additional clinical trials are necessary to assess the safety of MT-II in human test subjects and determine its potential correlation with skin cancer.
In a recent study investigating the protective effects of the melanocortin receptor (MCR) agonist, Melanotan-II (MTII), against binge-like ethanol drinking, intriguing findings shed light on the role of MC3 receptors (MC3Rs). Administering MTII, a nonselective MCR agonist, significantly reduced voluntary ethanol consumption in C57BL/6J mice. The study further delved into the neurocircuitry involved in binge-like ethanol intake using the “drinking in the dark” (DID) procedure, a commonly employed animal model. The research revealed that MC3R−/− mice, lacking normal expression of MC3Rs, exhibited heightened sensitivity to the protective effects of MTII, with all doses blunting binge-like ethanol drinking. In contrast, MC3R+/+ mice showed a dose-dependent response, with only the highest dose (1.0 μg) significantly reducing binge-like drinking. These results suggest that MC3Rs may counteract the protective effects of MTII against binge-like ethanol drinking, hinting at the potential therapeutic role of selective MC3R antagonists in addressing excessive ethanol consumption.[R]
The information presented here is for educational purposes only and should not be construed as medical advice. Melanotan-2 is intended for laboratory research use only and is not intended for human consumption.
Is Melanotan-2 legal?
Without medical approval or regulation comparable to that of research chemicals, Melanotan 2 does not possess the classification of prescription medication in several regions worldwide. Notably, ongoing research efforts are focused on clarifying the effects of the subject matter. Melanotan 2 is sometimes distributed and marketed for cosmetic or research purposes, with its primary benefit being its ability to enhance tanning. Even though some studies suggest minimal adverse effects at specific dosages, the safety and long-term effects of Melanotan 2 have not been adequately established. It is strongly advised that any utilization be supervised by a medical professional, notwithstanding these observations. It is crucial to emphasize that RCD Bio does not provide recommendations for the application of Melanotan 2 beyond the scope of scientific investigation.
Where Can I Buy Melanotan-2 online?
When buying melanotan, it is important to choose a reputable seller who provides quality products. At RCD.bio, each product is accompanied by a third-party-issued Certificate of Analysis showing the identification, purity, and concentration of our product.
In conclusion, Melanotan II (MTII) is offered by RCD.Bio has emerged as a subject of considerable scientific interest and research. Initially developed for investigating melanocortin receptors and their impact on skin color, MTII has shown unexpected but promising results in various areas of sexual health, insulin sensitivity, tanning, and even alcohol consumption. The nasal spray, with a purity of 98%, presents a convenient and efficient delivery method for researchers exploring the potential applications of MTII.
The key features of the Melanotan-2, including its purity, dosage, and chemical formula, highlight its suitability for scientific investigations. The interaction of MTII with central nervous system melanocortinergic receptors, particularly the MC4 receptor subtype, underscores its role in facilitating penile erection and addressing erectile dysfunction. Additionally, the melanocortin-3/4 receptor agonist properties of MTII demonstrate its potential to improve insulin sensitivity, with implications for targeted interventions in metabolic disorders.
Research findings also suggest MTII’s effectiveness as a tanning agent and its impact on alcohol consumption, providing avenues for further exploration in these areas. However, it is crucial to note that the product is intended solely for laboratory and research purposes, and its legal status varies across regions.
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