Melanostatin, an endogenous brain peptide, tripeptide known as L-prolyl-L-leucylglycinamide. Melanostatin first came to attention when it was found to be a natural hypothalamic factor. This compound has a unique job in the body. It stops the anterior pituitary gland from releasing the hormone that increases melanocytes. Melanostatin is like a key that fits a certain lock in our brains and changes how hormones work. It has a potential effect on the way the brain works, changing everything from behavior to the way the body moves. In fact, it has shown promise in improving the effects of some drugs used to treat Parkinson’s disease.[R]

Key Features of  MIF-1

RCD.Bio offers  MIF-1 with the following specifications:

  • A purity of 98%, verified by third-party laboratory testing.

MIF-1  [R]

  • CAS Number: 2002-44-0
  • Molecular weight: l  284.35 g/mol
  • Chemical Formula: C13H24N4O3
  • Synonyms: Pro-Leu-Gly-NH2; 2002-44-0, L-Prolyl-L-leucylglycinamide
  • IUPAC Name: (2S)-N-[(2S)-1-[(2-amino-2-oxoethyl)amino]-4-methyl-1-oxopentan-2-yl]pyrrolidine-2-carboxamide

How It Works

MIF-1, short for Melano-Inhibitory Factor-1, is a tripeptide (prolyl-leucyl-glycineamide) derived from oxytocin, a brain peptide hormone. Its mechanism of action and beneficial effects on the central nervous system (CNS) have been the subject of extensive research. In the olfactory cortex, MIF-1 initially depresses the amplitudes of focal potentials (FPs) triggered by lateral olfactory tract (LOT) stimulation. Scientists have been studying how it works and what good things it does in our blood-brain barrier. When they tested it, they found that Melanostatin does some interesting things. In one part of the brain called the olfactory cortex (which is involved in our sense of smell), MIF-1 first makes certain signals weaker. But then, after a while, it actually makes those signals stronger and adds some new ones. In the parietal cortex, Melanostatin elevates FP amplitudes evoked by nearby stimulation points. Studies suggest that MIF exerts an excitatory influence on the CNS by reversible hyperpolarization at the cellular level, potentially underpinning its benefits and potential therapeutic applications of MIF for conditions like depression and Parkinson’s disease [R]

MIF-1 Research

Numerous studies have been conducted on the potential application of Melanostatin. Below are some of the relevant findings on the MIF:

MIF-1 in Brain Function

Melanostatin , has shown intriguing benefits in research settings, particularly in understanding brain function. When Melanostatin is introduced into the brain’s ventricles, it has been observed to have a positive impact on both behavior and electrical activity in various brain regions, including the neocortex, amygdala, hippocampus, and hypothalamus. One notable effect is the enhancement of electrical activity in these brain areas. Specifically, Melanostatin increases the activity in the neocortex, which is involved in higher-level thinking, as well as in the amygdala and hippocampus, regions linked to emotions and memory. This enhanced electrical activity suggests that Melanostatin could play a role in improving brain function and communication between these important brain regions. Additionally, MIF-1’s interaction with morphine, a pain-relieving substance, is noteworthy. It seems that MIF-1 can either enhance or block the effects of morphine, depending on the circumstances, further highlighting its potential importance in understanding how different substances affect the brain. [R]

MIF-1 in stress induced analgesia

Melanostatine-1, or MIF-1, is used in research to better understand how the body responds to different substances and stressors. In a recent study with snails, scientists found that MIF-1, along with another chemical called Tyr-MIF-1, could block the pain-relieving effects of morphine and warm stress. This means that when these chemicals were present, the snails didn’t feel as much pain from heat or the effects of morphine. What’s fascinating is that MIF-1 and Tyr-MIF-1 seem to work in a way similar to how opioid antagonists function in mammals. This discovery hints at the possibility that certain aspects of how our bodies respond to opioids might be quite ancient in nature, with even snails showing similarities in their responses. [R] While these findings don’t promote the use of these chemicals in humans, they do shed light on the complex analgesic effects in different creatures, big and small, hot it might share some common mechanisms.

MIF-1 on Emotion and Behavior 

MIF-1 has shown some interesting benefits in research, particularly in studies conducted on cats and mice. In experiments with cats, Melanostatin appears to influence emotional reactions. It’s been observed to have actions similar to substances like L-DOPA and amantadin, affecting the way cats respond to emotions. While it may not function as a typical antidepressant, MIF seems to activate defensive behaviors in certain situations, like when cats experience reserpine-induced depression. Interestingly, it can also reduce aggressive behavior in cases of haloperidol-induced depression. In mice that have been treated with reserpine, MIF counters some of the effects of reserpine, such as hypothermia, and enhances muscle tone while reducing ptosis (drooping eyelids). Additionally, it has the potential to counteract catalepsy induced by haloperidol, a medication used for various purposes. MIF appears to work by increasing the levels of dopamine and its metabolite, homovanilic acid, in the brain. These findings highlight the complex and multifaceted effects of MIF in laboratory settings, contributing to our understanding of its potential applications in research. [R]

MIF-1 on Tremors

MIF-1 shows great potential in helping researchers better understand and manage tremors induced by oxotremorine. Its effects follow a dose-dependent pattern, with an optimal range for effectiveness. While the applications of MIF-1 remain primarily within the realm of scientific research, this knowledge paves the way for more informed and precise investigations into its beneficial effects, potentially offering insights into various neurological and experimental contexts. [R]


The information presented here is for educational purposes only and should not be construed as medical advice.  Melanostatin   is intended for laboratory research use only and is not intended as dietary supplements. In laboratory settings, clear solution co-solvents may be employed to dissolve this substance for experimental or research objectives. Furthermore, additional research studies are accessible and can be explored through various research platforms, including Google Scholar.

Where Can I Buy  MIF  online? offers  MIF for laboratory and research use only.

When buying custom peptides , it is important to choose a reputable market seller who provides quality control on MIF-1. At, customers can ensure each product is accompanied with a third-party-issued Certificate of Analysis showing the identification, purity, and concentration of our product. offers Melanostatin in sealed storage.


In summary, Melanostatin) is a remarkable tripeptide with a unique role in our bodies. It acts as a key, influencing hormone actiity in the brain by inhibiting the release of melanocyte-stimulating hormone (melanin formation). This influence extends to various brain regions, including directly crossing the neocortex, amygdala, and hippocampus, enhancing electrical activity and potentially improving brain function. Melanostatin also exhibits complex effects on emotions and behaviors in research settings, influencing reactions in cats and mice. Additionally, it shows promise in understanding and managing tremors induced by oxotremorine. All these benefits hint at the intriguing potential of Melanostatin in various neurological and experimental contexts.


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