Modified GRF 1-29, also known as CJC-1295 without DAC, is a synthetic derivative of growth hormone-releasing hormone (GHRH) designed for research purposes only. GHRH is a natural chemical in the body responsible for stimulating the production of growth hormones. Classified as a growth hormone secretagogue, Modified GRF 1-29 acts to increase the secretion of growth hormone from the pituitary gland.

Termed Modified Growth Releasing Factor aminos 1-29 or ModGRF(1-29), this compound is a synthetic analog of the endogenous peptide signaling hormone Growth Hormone Releasing Hormone (GHRH). The native GHRH comprises 44 amino acids, while the synthetic GRF 1-29 (Sermorelin) contains 29 amino acids. Modified GRF (1-29) goes a step further with four substituted amino acids in its chain. These substitutions serve crucial roles in preventing degradation and oxidation during manufacturing, transportation, and in vivo applications. Simultaneously, they enhance binding affinity to the GHRH receptors, contributing to the compound’s effectiveness.

As compared with CJC-1295 with DAC the peptide that lacks DAC demonstrates a shorter half-life.

It’s essential to underscore that Modified GRF 1-29, or CJC-1295 without DAC (DAC means drug affinity complex), is strictly meant for research purposes. Researchers employ this synthetic compound in controlled laboratory settings to investigate its impact on growth hormone release and related physiological functions.

Key Features

  • 98% Purity
  • Sold for research purposes only and not for human consumption
  • Nasal Spray: 20mcg per spray/10ml/2mg
  • Sublingual Tablets: 100mcg per tablet/30ct/3mg

Potential Benefits of Mod GRF 1-29 (CJC-1295 No DAC)

Modified GRF elicits similar effects to GHRH, encompassing muscle growth (hypertrophy), expedited wound healing, enhanced bone growth, increased fat burning, and a boosted metabolism for muscle-building goals. Additionally, Modified GRF may exhibit positive impacts on both the immune system and the regulation of blood sugar.

Mod GRF 1-29 Research and Lean Muscle Mass

The potential benefits of Mod GRF 1-29 (CJC-1295 Without DAC) come to light in its demonstrated ability to increase muscle mass through various mechanisms. Research suggests that this synthetic peptide promotes the growth and differentiation of muscle cells, contributing to enhanced muscle development. Additionally, Mod GRF 1-29 stimulates the production of insulin-like growth factor 1 (IGF-1), a key mediator in the growth-promoting effects of growth hormone. [R]

The promotion of muscle cell growth and the elevation of IGF-1 levels make Mod GRF 1-29 a compelling subject of study for researchers interested in understanding and potentially manipulating muscle development. These findings open avenues for investigating the peptide’s impact on muscle-related conditions, performance enhancement, or muscle-wasting disorders.

Mod GRF 1-29 Research and Fat Loss

The potential benefits of Mod GRF 1-29 (CJC-1295 Without DAC) extend to its demonstrated ability to facilitate fat loss through distinct physiological mechanisms. Research indicates that this synthetic peptide can positively influence body composition by elevating the metabolic rate. This increase in metabolic activity promotes the utilization of stored body fat as an energy source. [R]

The promotion of fat loss through enhanced metabolic rate positions Mod GRF 1-29 as a subject of interest for researchers exploring avenues related to weight management, metabolic disorders, and overall body composition modulation. These findings present potential implications for understanding the peptide’s impact on metabolic processes and its role in addressing conditions associated with excessive fat accumulation.

Mod GRF 1-29 Research and Intestine

The potential benefits of Mod GRF 1-29 (CJC-1295 Without DAC) in the context of intestinal health are a subject of interest in current research. Early studies indicated that growth hormone (GH) could positively impact conditions such as Crohn’s disease, short bowel syndrome, and other inflammatory bowel disorders. However, the downsides of long-term exogenous GH administration, including significant side effects, raised concerns about its practical application in this setting. [R]

In response to these challenges, researchers have turned their attention to GHRH analogs, specifically exploring whether Mod GRF could offer similar positive effects on the intestine without GH’s associated serious side effects. Studies conducted in monkeys have provided preliminary insights, suggesting that Mod GRF interacts with vasoactive intestinal peptide (VIP) receptors, leading to an enhancement in bowel motility.

It’s crucial to emphasize that Mod GRF 1-29 (CJC-1295 Without DAC) is strictly intended for research use only. While these preliminary findings are promising, further research is essential to fully understand the potential therapeutic applications of Mod GRF in addressing inflammatory bowel conditions.

Mod GRF 1-29 Research and Heart Function

Exploring the potential benefits of Mod GRF 1-29 (CJC-1295 Without DAC), research in rodent models has indicated that this compound, along with other GHRH derivatives, may offer advantages in enhancing heart function, particularly in the aftermath of a heart attack. The findings suggest an improved ability of the heart to pump blood, a crucial factor in the recovery process following cardiac events. [R]

This discovery holds significant promise in the realm of cardiovascular health, potentially contributing to an enhanced quality of life and a reduced risk of long-term mortality for individuals diagnosed with heart failure. The implications of this research extend to a broad spectrum of cardiovascular conditions, including but not limited to pulmonary hypertension, heart failure, heart attack, and various congenital heart conditions.

It’s vital to underscore that Mod GRF 1-29 (CJC-1295 Without DAC) is designated for research use only. While these findings present intriguing possibilities, further research is imperative to fully comprehend the therapeutic applications of Mod GRF in the context of heart function and cardiovascular health.

Mod GRF 1-29 Research and Thyroid Hormone

The potential benefits of Mod GRF 1-29 (CJC-1295 Without DAC) extend into the intricate interplay between the thyroid gland and growth hormone (GH) release. Individuals facing issues with their thyroid glands often experience related challenges in GH release. To delve deeper into this connection, scientists conducted studies where test subjects with hypothyroidism were stimulated with modified GRF. The results demonstrated that those receiving thyroid replacement hormone exhibited stronger reactions to GRF, establishing a clear link between thyroid hormone and GH. [R]

This observation represents just one facet of how peptides like modified GRF contribute to advancing our understanding of human physiology. By investigating these interactions, scientists gain insights that may pave the way for novel therapeutic approaches and targeted interventions.

How Does Mod GRF 1-29 Work?

The mechanism of action of Mod GRF 1-29 (CJC-1295 Without DAC) closely mirrors that of the body’s natural Growth Hormone Releasing Hormone (GHRH). This synthetic growth hormone-releasing peptide operates by binding to the Growth Hormone Releasing Hormone receptor (GHRHr) located in the anterior part of the pituitary gland. Once bound, it initiates a cascade of events aimed at enhancing the pulsatile release of growth hormone.

The primary outcome of Mod GRF 1-29’s interaction with the GHRH receptor is the stimulation of increased growth hormone production. This, in turn, triggers a rise in the levels of Insulin-like Growth Factor-1 (IGF-1), a key player in various growth and metabolic processes. Notably, Mod GRF 1-29 demonstrates its optimal efficacy when administered concurrently with a natural growth hormone release in the body. This synchronization can be achieved by aligning the administration with the body’s inherent growth hormone release or by co-administering it with a Growth Hormone Releasing Peptide (GHRP). This combined approach further amplifies the effects of both peptides.


When researching Mod GRF 1-29 (CJC-1295 Without DAC) nasal spray, it is essential to take certain precautions. Here are some precautions to keep in mind:

Observe best practices for studying research chemicals

Studying research chemicals requires a responsible and informed approach to ensure safety and meaningful scientific exploration. Research chemicals, also known as designer drugs or experimental compounds, are substances synthesized for scientific investigation or exploration of their properties.

Follow the recommended dosage in the warning section

Adhere to the recommended dosage instructions outlined on the product label. Avoid a significant increase of the suggested dose to minimize the risk of potential adverse effects among test subjects.

Potential Side Effects

The side effects associated with Modified GRF 1-29 are generally mild and dose-dependent, with negative effects seldom occurring at moderate dosage levels. According to research studies, test subjects may experience mild and transient symptoms, including skin flushing, nausea, stomach upset, dizziness, and/or headaches.

Why Consider Research Chemicals in Nasal Sprays

Nasal spray is a delivery method for research chemicals that involves administering the substance through the nasal passages. This form is preferred by some researchers for several reasons. Firstly, nasal spray offers a non-invasive and convenient route of administration, eliminating the need for injections. This can be advantageous in research settings, simplifying the process and potentially reducing stress for study subjects.

Secondly, nasal administration allows for quick absorption of the research chemical into the bloodstream through the nasal mucosa. The rich blood supply in the nasal cavity facilitates rapid onset of action, making it an efficient delivery method.

Moreover, nasal sprays often provide precise dosage control, enabling researchers to administer accurate amounts of the substance. This accuracy is crucial for maintaining consistency in research experiments and ensuring reliable results.

Overall, nasal spray for research chemicals offers a practical, efficient, and precise delivery method, making it a favorable option for certain research applications compared to other forms of administration.

Why Consider Research Chemicals in Sublingual Tablets?

Sublingual tablets offer a convenient and standardized form for administering research chemicals, promoting consistency in dosage and facilitating accurate data collection. Researchers can delve into the pharmacokinetics and other aspects of these compounds, contributing to the broader understanding of their properties and potential therapeutic implications in a research context.


In summary, Mod GRF 1-29 (CJC-1295 Without DAC) is a synthetic growth hormone-releasing hormone analog with potential benefits in various research applications. 

Its mechanism of action involves binding to GHRH receptors, stimulating growth hormone release, and influencing factors like bowel motility, weight loss, protein synthesis, bone health, and heart function. 

Notably, its mild and dose-dependent side effects, coupled with convenient nasal spray administration, make it a promising candidate for scientific research studies exploring growth hormone regulation and related physiological processes. Researchers should, however, strictly adhere to ethical guidelines and recognize its exclusive use for research purposes.