N-Acetyl Epithalon Amidate


Based on a naturally occurring peptide called epithalamion that is isolated from the pineal gland, epitalon is a short synthetic peptide made of four amino acids (alanine, glutamic acid, aspartic acid, and glycine). [R]

According to studies, Epithalon may be able to increase the production of the cellular enzyme telomerase, which is essential for determining cell fate and aging. [R] The cause of aging is correlated when telomeres shorten, this is why epitalon showed a promising effect as anti-aging since it activates telomerase which lengthens telomeres. Telomerase also prevents decline in some cells, including stem cells, by increasing telomere extension.

Key Features

rcd.bio offers N-Acetyl Epithalon Amidate (Epitalon) with the following specifications:

  •  A purity of 98%, verified by third-party laboratory testing.
  • A 100mg powder form.
  • A Bacteriostatic Water is also included

The Bacteriostatic water, a sterile preparation, is used for the purpose of diluting or dissolving research chemicals. The addition of benzyl alcohol to the bacteriostatic water renders it inhibitory to the growth of a majority of potential contaminants, thereby facilitating the safe reuse of the container multiple times with the aid of a sterile needle.

Chemical Profile Epithalon (Epitalon)

  • CAS Number: 307297-39-8
  • Molar Mass: 90.349g.mol-1
  • Chemical Formula: C14H22N4O9
  • IUPAC Name: (4S)-4-[[(2S)-2-aminopropanoyl]amino]-5-[[(2S)-3-carboxy-1-(carboxymethylamino)-1-oxopropan-2-yl]amino]-5-oxopentanoic acid

How Epitalon Works?

The chromosomes’ protective caps, known as telomeres, are located at the ends of each DNA strand. They are made up of repeated DNA sequences and related proteins, and their main purpose is to preserve vital genetic material during cell division and protect the genetic information within them. When telomeres are too short, a cell stops replicating and enters a condition of senescence or programmed cell death. Telomeres continuously shorten as cells divide and replicate. Telomeres thus have a significant impact on aging and disorders associated with old age. [R]

Epitalon may increase the body’s production of telomerase. The enzyme telomerase is found at the two ends of each chromosome, according to the study. It might be feasible to stop aging by possibly enhancing telomerase production. [R]

Epitalon has the possibility of eliminating free radicals as according to an animal study, Epitalon peptide is a potent antioxidant that is comparable to melatonin and may lengthen life.  [R]

Another mechanism according to studies, epithalon regulates the expression of genes that are connected to different cell systems on a functional level. This synthetic peptide interacts with DNA sites in the promoter regions of the genes that make the signaling molecules CD5, IL-2, MMp2, and Tram1, according to research. [R]

The scientific basis behind the benefits of N-Acetyl Epithalon Amidate

The effectiveness and safety of Epitalon have been explored. Epitalon has been thoroughly studied for its potential usefulness in treating a number of different diseases. The following list of recent Epitalon research topics includes:

Eye Health

In eye health, it was able to possibly help retinal function in rats with retinitis pigmentosa, a hereditary condition that causes blindness suggests improvement. [R]

Cardiovascular Health

Cardiovascular mortality risk is cut in half as suggested by a study. [R]

Metabolism Conditions

A study also showed that epitalon can lower levels of LDL and total cholesterol which can exert a stress-protective effect. [R]

Other than increasing the activity of telomerase in living cells, restoring blood sugar tolerance and restoring normal insulin response to glucose in rhesus monkeys, i.e., increased insulin sensitivity has been explored for epitalon. [R]


According to a study done on female transgenic mice, a single dose of Epitalon (Ala-Glu-Asp-Gly) given over 5 days in a row each month dramatically decreased the total number and maximum size of tumors.  The data indicate that the downregulation of HER-2/neu gene expression in mammary adenocarcinoma is at least largely responsible for Epitalon’s anticancer activity. [R]

Difference between Epitalon and N-Acetyl Epitalon Amidate

The peptides Epitalon (also known as Epitalon) and N-Acetyl Epitalon Amidate peptide (also known as Epitalon Amidate or abbreviated as AEDG) have chemical structures that are similar, yet they differ significantly in some important ways.

Epithalon’s half-life, stability, and effectiveness are altered, but the peptide’s general function remains unchanged. The native peptide is only modified in two ways: N-acetylation and amidation. Each one provides distinct advantages that boost the potency of Epithalon and allow for slower phosphate administration. Acetylation is a common, natural process that occurs in many regions of the body. It is also a mechanism used by the pharmaceutical industry to help a chemical reach the central nervous system.

Acetylated molecules form by acetylation and the amidated proteins have been shown to potentially increase the pace at which a molecule crosses the blood-brain barrier, boosting the intensity of the compound’s effects and aiding in the reduction of required dosage. To understand better aspirin, for example, is a modified version of salicylic acid. According to the study, the inclusion of salicylic acid enhances the molecule’s anti-inflammatory properties.

The addition of acetyl and amidated groups to the amino acid sequence in Epitalon Amidate is the main distinction between Epithalon and Epitalon Amidate. This acetyl group changes the peptide, improving its stability and bioavailability.

As a result, Epitalon Amidate is typically regarded as a stronger and more efficient version of Epithalon. It is additionally believed to have a longer half-life, which denotes a longer amount of time during which it is active in the body. [R]

Epitalon Amidate has been demonstrated to have more focused effects on telomerase activity and telomere length, whereas Epitalon has a wider range of effects on the endocrine system and immunological function. This is another difference between the two peptides.  [R]

Overall, despite the similarities in the characteristics and advantages of the two peptides, Epitalon Amidate is a more developed and potent version of Epitalon because of its altered structure and increased bioavailability due to its improved receptor binding.


The information presented here is for educational purposes only and should not be construed as medical advice. Epitalon is intended for laboratory and research use only and is not intended for human consumption.

Potential side effects

There are no known negative effects associated with Epitalon.

Frequently Ask Questions (FAQs)

Can Epitalon stop the aging process?

Epitalon may have anti-aging properties as research suggests, but further research needs to be done.

Where Can I Buy the Best Epitalon?

rcd.bio offers N-Acetyl Epithalon Amidate (Epitalon)  for sale online. rcd.bio sells N-Acetyl Epithalon Amidate for laboratory research use only.

rcd.bio offers N-Acetyl Epithalon Amidate (Epitalon)  as research chemicals, so it is important to choose a reputable seller who provides quality products. At rcd.bio, each product is accompanied by a third-party-issued Certificate of Analysis showing the identification, purity, and concentration of our product. 

RDC.Bio also offers N-Acetyl Epithalon (Epitalon) powder only in 100mg dosage.

N-Acetyl Epithalon (Epitalon) is a peptide with a similar chemical structure to N-Acetyl Epitalon Amidate. However, unlike Epitalon Amidate, it lacks the extra acetyl amidated group in its amino acid sequence, which can improve its stability and bioavailability. Epitalon is less potent than Epitalon Amidate, yet it still has significant potential.


Epitalon is a synthetic tetrapeptide made of four amino acids that may increase the production of telomerase, an enzyme essential for determining cell fate and aging. Telomeres, the protective caps at the ends of DNA strands, shorten as cells divide and replicate, leading to aging and disorders associated with old age. Epitalon has the potential to increase telomerase production and eliminate free radicals, making it a potent antioxidant. Additionally, studies suggest that epithalon may regulate the expression of genes connected to different cell systems and exert stress-protective effects, lower levels of LDL and total cholesterol, and restore blood sugar tolerance and normal insulin response to glucose. Epitalon Amidate is a more potent and efficient version of Epitalon, with more focused effects on telomerase activity and telomere length. 


Please take note of the scientific applications of this product and carefully read our Terms and Conditions before making a purchase from rcd.bio. By completing your order and submitting payment, you agree to abide by our Terms and Conditions. Please be aware that the product packaging may differ slightly from the images displayed on our website.

If for any reason you are not completely satisfied with the product you receive, please contact us at [email protected]. Our team is dedicated to ensuring customer satisfaction and will be happy to assist you.

PLEASE NOTE: All products offered by rcd.bio are strictly intended for laboratory and research purposes only. They are not intended for use on animals or humans.