N-Acetyl Epithalon 


Epitalon is a short synthetic peptide comprised of alanine, glutamic acid, aspartic acid, and glycine that is based on epithalamion, a naturally occurring peptide derived from the pineal gland. [R]

Studies suggest that the cellular enzyme telomerase, which is critical for regulating cell destiny and aging, can be produced more abundantly by Epithalon. [R] Thus, suggests anti-aging properties of the research compound.

Key Features

rcd.bio offers N-Acetyl Epithalon (Epitalon) as research chemicals with the following specifications:

  • A purity of 98%, verified by third-party laboratory testing.
  • A 100mg powder form.

Epithalon (Epitalon)

  • CAS Number: 307297-39-8
  • Molar Mass: 90.349g.mol-1
  • Chemical Formula: C14H22N4O9
  • IUPAC Name: (4S)-4-[[(2S)-2-aminopropanoyl]amino]-5-[[(2S)-3-carboxy-1-(carboxymethylamino)-1-oxopropan-2-yl]amino]-5-oxopentanoic acid

How Epitalon Works?

Telomeres, the chromosomes’ protective caps, are found at the ends of each DNA strand.Their key function is to keep the genetic information contained inside them and to retain vital genetic material throughout cell division. They are made up of repeating DNA sequences and proteins. A cell undergoes senescence, or programmed cell death, when its telomeres shorten and it stops replicating. Telomeres gradually get shorter when cells divide and multiply. Telomeres thus play a crucial role in aging and age-related diseases. [R]

The use of epitalon might boost the body’s telomerase production. According to a study, the telomerase enzyme is located at the two ends of each chromosome. By perhaps increasing the synthesis of telomerase, it might be possible to prevent aging. [R]

According to an animal study, Epitalon peptide is a powerful antioxidant that is comparable to melatonin and may extend life, therefore it may be able to destroy free radicals. [R]

Epithalon is another mechanism that, in accordance with studies, controls the functional expression of genes linked to various cell systems. According to studies, this synthetic peptide interacts with DNA locations in the promoter regions of the genes responsible for producing the signaling molecules CD5, IL-2, MMp2, and Tram1. [R]

The scientific basis behind the benefits of N-Acetyl Epithalon Amidate

The efficacy and safety of Epitalon have been investigated. Epitalon has undergone substantial research because of its potential to be useful in possibly improving a number of ailments. The following list of recent Epitalon study subjects is just a sample:

Reproductive Health

The quality of oocytes (egg cell) decreases over time after ovulation in vivo or in vitro. A study was conducted to assess the preventive effects of Epitalon on the state of post-ovulatory aged oocytes in vitro. The epitalon trial dramatically reduced the frequency of spindle abnormalities and aberrant cortical granule distribution during aging for 12h and 24h, while improving mitochondrial membrane potential and DNA copy number, and so decreasing oocyte death by 24h of in vitro aging. [R]

Cholesterol levels

Additionally, a study revealed that epitalon may possibly lower LDL and total cholesterol levels, which can have a stress-protective impact.  [R]

Insulin sensitivity

In addition to boosting telomerase activity in living cells, epitalon has also been studied for its potential to improve insulin sensitivity and improve blood sugar tolerance in rhesus monkeys. [R]


A single dose of Epitalon (Ala-Glu-Asp-Gly) administered over 5 days in a row each month significantly reduced the total number and maximum size of tumors, according to a study done on female transgenic mice.  The results show that the anticancer action of Epitalon is at least in part caused by the downregulation of HER-2/neu gene expression in breast adenocarcinoma. [R]

Eye Care

Improved eye health is shown by rats with retinitis pigmentosa, a genetic disorder that results in blindness, having fixed retinal function.  [R]

Cardiovascular Health

According to a study, the risk of cardiovascular mortality is decreased in half. [R]

Difference of N-Acetyl Epitalon and N Acetyl Epitalon Amidate peptide

The half-life, stability, and effectiveness of epithalon are altered, while the peptide’s overall function remains constant. The original peptide undergoes only two modifications: N-acetylation and amidation. Each offers unique properties that boost the potency of Epithalon while allowing for slower phosphate dosing. Acetylation is a widespread and natural process that happens throughout the body. It is also a mechanism employed by the pharmaceutical industry to aid in the delivery of a substance to the central nervous system.

An extra amide group has been added to the amino acid chain of N-Acetyl Epitalon Amidate, a more recent variant of N-Acetyl Epitalon. The goal of this change is to increase the peptide’s stability and absorption in the body.

The amide group in N-Acetyl Epitalon Amidate is hypothesized to lengthen the peptide’s half-life and make it more resistant to being broken down by bodily enzymes. This suggests that N-Acetyl Epitalon Amidate may provide greater anti-aging advantages than N-Acetyl Epitalon. [R]

Acetylated molecules, which are formed by acetylation and amidated proteins, have been demonstrated to potentially speed up the rate at which a molecule crosses the blood brain barrier, increasing the potency of the compound’s effects and assisting in the reduction of required dosage. To put it another way, aspirin is a modified version of salicylic acid. According to research, adding salicylic acid to the molecule improves its anti-inflammatory capabilities.

The key difference between Epithalon and Epitalon Amidate is the addition of acetyl and amidated groups to the amino acid sequence in Epitalon Amidate. The peptide is altered by this acetyl group, which improved receptor binding and stability.


This material is being provided for educational reasons only; it is not intended to be taken as medical advice. Epitalon is not meant for human consumption and is only meant for use in laboratories as a research chemical.

Potential side effects

Clinical studies have revealed that the synthetic peptide Epitalon Amidate is generally well-tolerated and safe. There are no known toxicities or adverse effects associated with it.


A four-amino acid synthetic tetrapeptide called epitalon may boost the synthesis of telomerase, an enzyme crucial for determining cell destiny and aging. As cells divide and replicate, telomeres, the protective caps at the ends of DNA strands, shorten, causing aging and illnesses related to aging. Epitalon is a potent antioxidant since it has the capacity to boost the production of telomerase and destroy free radicals.

Studies imply that epithalon controls the expression of genes related to many cell systems, protects against stress, decreases levels of LDL and total cholesterol, and restores blood sugar tolerance and a normal insulin response to glucose. Epitalon is less potent than epitalon amidate.


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