NAD+ (nicotinamide adenine dinucleotide) is a pivotal coenzyme involved in critical cellular activities, including energy production, DNA repair, inflammatory regulation, hormone signaling, circadian rhythms, cognition, muscle function, and more. Our nasal NAD+ compound provides a concentrated dose of this essential molecule to help investigate and replenish age-related declines.

As we get older, NAD+ levels deplete over time, accelerating aging and contributing to dysfunction. Restoring NAD+ has been shown to activate youthful cellular pathways and enhance function. Our pure NAD+ formula is expertly crafted using a patented fermentation process identical to natural NAD+ synthesis.

Our NAD+ nasal spray is currently available for research purposes only while further therapeutic applications and biological mechanisms continue to be explored. Intranasal delivery is believed to provide quicker access to brain cells which is why it could be the ideal product for research studies regarding NAD+.

Key Features

  • 98% Purity
  • Sold for research purposes only and not for human consumption
  • 5mg per spray/10ml/500mg

Potential Benefits of NAD+ (Nicotinamide Adenine Dinucleotide)

NAD+ (nicotinamide adenine dinucleotide) is an essential coenzyme involved in critical cellular activities that regulate healthy aging. It plays key roles in mitochondrial function, metabolism, DNA repair, and gene expression related to lifespan.

Research shows that NAD+ levels dramatically decline with age in multiple species. This depletion has been associated with impaired cellular function and accelerated aging. Diminished NAD+ reserves correlate with the onset and progression of age-related diseases like metabolic disorders, heart disease, and neurodegeneration.

Studies suggest that preserving NAD+ levels may promote healthy metabolism and mitigate age-related decline. Animal models have demonstrated that sustaining NAD+ content can preserve aspects of youthful cellular function into advanced age. However, more research is still needed to fully understand the mechanisms.

While promising, the long-term effects of sustained NAD+ repletion remain unknown in humans. Buy NAD+ for research purposes only.

1. Aging

Sirtuins are a class of genes that regulate critical defense systems within organisms to promote health and longevity. They protect against genomic instability, facilitate DNA repair, and have exhibited anti-aging effects in animal studies – such as extended lifespan.

However, sirtuins require adequate levels of the coenzyme NAD+ to function properly and trigger these beneficial pathways. NAD+ is an essential “fuel” to activate sirtuins and drive their protective roles.

Research in model organisms like yeast, worms, and mice indicates replenishing NAD+ content can sufficiently rouse sirtuin activity for amplified longevity. Though these findings appear promising, further investigation regarding applicability to humans is still needed before conclusions are drawn. [R]

Scientists emphasize that while preliminary results suggest sustained NAD+ repletion may stimulate sirtuin expression and maintain genomic integrity – potentially conferring anti-aging effects – considerable research remains to elucidate the clinical impact for humans fully.

2. Cognitive Function

Emerging animal research suggests that maintaining adequate cellular levels of the coenzyme NAD+ may have neurological benefits. such as mental clarity. Studies in mouse models indicate supplementing NAD+ can reduce destructive protein buildup and cell death common in neurodegenerative conditions.

In Alzheimer’s disease models, elevating NAD+ content appeared to lessen neuronal plaque accumulation while improving cell signaling and cognitive function. Other early studies propose that sustained NAD+ could shield brain cells against oxygen deprivation injury.

However, the mechanisms in human brains remain largely undefined. While these preliminary rodent findings provide early clues into potential interactions between NAD+ biology and age-related neuronal decline, efficacy for human neurological conditions requires much more investigation.

3. Heart Function

Cardiovascular disease remains a leading cause of mortality, often linked to age-related arterial stiffening and high blood pressure. As arteries lose elasticity over time, this can cause enlarged heart size, blocked arteries, strokes, and other cardiovascular damage.

Emerging research indicates that maintaining adequate levels of the coenzyme NAD+ may confer protective cardiovascular benefits. Animal studies have shown the potential for NAD+ repletion to preserve heart function and shield against lesion formation caused by inadequate blood flow. [R]

Additionally, early evidence suggests sustained NAD+ levels could defend against abnormal heart enlargement in mice models. However, the mechanisms behind these effects remain not fully characterized.

While initial results seem promising, scientists emphasize much more investigation is still required to understand if boosting NAD+ content could support healthy circulatory function in humans.

4. Muscle Function

Mitochondria act as the powerhouses of the cell, producing energy that fuels cellular activity. Maintaining mitochondrial health is especially important in active muscle cells. As we age, mitochondrial function often declines, impairing muscle performance.

Research suggests the coenzyme NAD+ plays a key role in preserving muscular mitochondrial integrity over time. Animal studies indicate replenishing NAD+ content may rejuvenate aged muscle mitochondria and enhance fitness.

In mouse models, sustained NAD+ levels correlated with increased exercise capacity, endurance, and leanness. However, the mechanisms driving these effects require further elucidation, especially about translation into human outcomes. [R]

While initial results provide early evidence that NAD+ repletion could potentially support muscle cell energy production and exercise ability, an abundance of additional investigation is still needed. Consult a trusted healthcare provider before altering any fitness regimens or nutritional intake.

5. Metabolic function

Obesity and associated disorders like diabetes are highly prevalent conditions reaching epidemic proportions globally. Research indicates that declining NAD+ levels attributed to aging and lifestyle factors may contribute to metabolic dysfunction.

Some animal studies suggest sustaining NAD+ content could potentially confer certain metabolic benefits – alleviating age and diet-related weight gain in mice while improving exercise capacity. Other early mouse research hints that NAD+ repletion may mitigate aspects of diabetes progression. [R] [R]

However, the mechanisms of these effects remain not fully characterized and require much more investigation, particularly translational human studies. Long-term safety and efficacy have yet to be demonstrated.

While emerging science proposes that preserving NAD+ levels may someday provide a pathway to support healthy metabolism, extensive prudence is warranted about implications for patients. Those with obesity or diabetes should consult medical professionals before altering recommended lifestyle or treatment regimens.

6. How It Works

NAD+ (nicotinamide adenine dinucleotide) is an essential coenzyme that enables critical biological reactions within cells to sustain life. It works by transferring electrons between molecules to facilitate metabolic processes.

Together with its counterpart NADH, this molecule plays integral roles in numerous cellular pathways – most critically energy production. By carrying protons and electrons, NAD+ helps unlock energy from nutrients to power cellular activity. Without adequate NAD+ reserves, cells cannot generate the energy needed for basic function.

Beyond energy generation, NAD+ also regulates other vital systems like circadian rhythms that control sleep/wake cycles through gene expression. The molecule is necessary for hundreds of enzyme-driven processes across biology.

While research continues into the multifaceted bioactivities of NAD+, what remains undisputed is its elemental requirement for cellular viability and health. Future investigations may uncover even more biological roles for this fundamental coenzyme.


When researching the use of NAD+ (Nicotinamide Adenine Dinucleotide) nasal spray, it is essential to take certain precautions. Here are some precautions to keep in mind:

Observe best practices for studying research chemicals

Studying research chemicals requires a responsible and informed approach to ensure safety and meaningful scientific exploration. Research chemicals, also known as designer drugs or experimental compounds, are substances synthesized for scientific investigation or exploration of their properties.

Follow the recommended dosage in the warning section

Adhere to the recommended dosage instructions outlined on the product label. Avoid a significant increase of the suggested dose to minimize the risk of potential adverse effects among test subjects.

Potential Side Effects of NAD+ (Nicotinamide Adenine Dinucleotide)

As with any research compound, moderation, and responsible oversight is advisable when studying NAD+. While generally well-tolerated, NAD+ may cause short-term side effects in some subjects.

The most common symptoms in subjects appear to be nausea, fatigue, brain fog, headaches, diarrhea, indigestion, stomach discomfort, and cramping. The mechanisms behind these effects remain understudied but are likely tied to rapid changes in cell energy pathways or enzymatic processes provoked by an abrupt NAD+ surplus.


In summary, emerging science suggests NAD+ may have the potential to influence cellular metabolism, energy levels, overall health, and cell function by raising declining reserves. Some early research hints at possible wellness benefits related to these biological activities. However, considerable further investigation in humans is still urgently required to fully characterize efficacy and safety. Researchers emphasize that while animal models show promising results, extreme caution is warranted about drawing conclusions or making recommendations around supplementation.