Nefiracetam is a fascinating nootropic chemical that belongs to the racetam family. Nefiracetam has gained attention for its potential benefits in those with cognitive difficulties because of its ability to improve memory, learning, and cognitive functions.[R]
Nefiracetam is a derivative of Piracetam and is said to be more powerful and have more positive effects. Nefiracetam is an interesting possibility for additional study because preliminary research indicates it may have antidementia effects in rats[R]. Further, it has been demonstrated in a number of animal models to have promise as an anti-amnesic agent, able to mitigate the memory-depleting effects of chemicals including ethanol, bicuculline, picrotoxin, chlorodiazepoxide, scopolamine, and cycloheximide. [R]
Remember, while Nefiracetam holds promise, it is essential to abide by ethical guidelines and regulatory requirements. RCD.Bio ensures that their supply of Nefiracetam is specifically intended for research purposes only not for human use. So, let’s learn more about Nefiracetam by looking at how it works, what it does, and how it might be used in scientific research.
RCD.Bio offers Nefiracetam with the following specifications:
- A purity of 99%, verified by first and third-party laboratory testing.
- Available in tablet form: 100mg/20ct/2g and 100mg/40ct/4g
- CAS Number: 77191-36-7
- Molecular weight: 246.310 g·mol−1
- Molecular Formula : C14H18N2O2
- IUPAC Name: N-(2,6-dimethylphenyl)-2-(2-oxopyrrolidin-1-yl)acetamide
- Synonyms: 77191-36-7; N-(2,6-dimethylphenyl)-2-(2-oxopyrrolidin-1-yl) acetamide; Translon; DM 9384
How Nefiracetam Works?
Nefiracetam, a potent member of the racetam family, is a nootropic compound used as cognitive enhancer This remarkable substance is believed to possess even greater efficacy than its predecessor, Piracetam.[R]
The mechanism of action through which Nefiracetam operates involves the restoration of normal neurotransmission in specific areas of the brain, particularly those associated with cholinergic, GABA, and possibly glutamate signaling. By exerting neuro-regulatory effects, Nefiracetam aims to optimize the functioning of these essential neurotransmitter systems.[R]
Notably, Nefiracetam appears to enhance both cholinergic and GABAergic signaling. As a cyclic derivative of GABA, nefiracetam exhibits a strong affinity for the GABAA receptor, where it is believed to act as an agonist. Additionally, it has been found to stimulate NMDA receptors, metabotropic glutamate receptors (mGluR5), and both N-type and L-type voltage-gated Ca2+ channels. These multifaceted interactions contribute to its comprehensive modulation of neurotransmission.Moreover, Nefiracetam’s effects on hippocampal neurotransmission are noteworthy. It achieves this by selectively targeting nicotinic ACh receptors, functioning independently of the effects seen with piracetam and aniracetam. By engaging with these receptors, Nefiracetam promotes optimal communication within the hippocampus, a brain region crucial for memory formation and cognitive processes.[R] [R]
The Laboratory and Research purposes of Nefiracetam
Animal models have been used to learn more about how Nefiracetam could be used. Here are a few of the most important findings:
In the field of clinical research on nootropics, one of the primary goals is the development of effective cognitive enhancers. Cognition encompasses various essential aspects such as memory, learning ability, critical analysis, logical thinking, attention, perception, planning, and impulse control [R]. It is widely recognized that substances like Nefiracetam and other Racetams have the potential to enhance many of these cognitive functions, making them promising candidates for addressing memory-related concerns [R]
Numerous clinical studies have shed light on the benefits of Nefiracetam when it comes to memory and learning. For instance, rats supplemented with Nefiracetam exhibited improved memory formation and recall abilities [R].
Nefiracetam, under controlled laboratory conditions, can enhance information processing and cognitive performance. As a result, information can be better retained for both short-term and long-term memory [R]
The positive impact of Nefiracetam on memory and learning opens up possibilities for its potential application as a aid for memory loss associated with aging, stroke, Alzheimer’s disease, or brain trauma. By enhancing memory formation and retention, Nefiracetam holds promise as a potential therapeutic option for individuals experiencing cognitive decline [R].
It’s important to note that while the scientific evidence supports the cognitive benefits of Nefiracetam, it is crucial to use this substance responsibly and strictly for research purposes. Continued research efforts will undoubtedly contribute to our knowledge of Nefiracetam and its potential applications in the field of cognitive enhancement.
In addition to its cognitive benefits, Nefiracetam has shown the potential to reduce stress and anxiety, making it relevant in the context of depression ,. Research conducted on olfactory bulbectomized mice, known for their depressive-like behavior, revealed unexpected antidepressant effects following Nefiracetam administration. Interestingly, these effects were observed as early as one day after the mice received a dose of Nefiracetam. This positive impact is believed to be associated with the compound’s ability to modulate metabotropic glutamate receptors, thereby influencing depressive symptoms [R]
Another intriguing finding suggests that Nefiracetam’s calming effects may extend to reducing seizure activity in rats. This discovery highlights the compound’s potential as an anti-epileptic agent, further supporting its broad range of beneficial effects [R]
Furthermore, Nefiracetam holds promise in the possibility of enhancing the well-being of stroke victims. A double-blind, randomized treatment study was conducted on patients who experienced depression following a stroke. The results indicate that Nefiracetam may have a positive impact in treating depressive symptoms associated with stroke [R]
Researchers suggest that Nefiracetam may contribute to improved visual acuity, allowing the brain to process light and color more effectively. This synthetic substance is believed to have a significant impact on enhancing attention and reducing eye strain, making it beneficial for individuals engaged in tasks that require sustained visual focus[R]
Nefiracetam may be helpful for many workers who spend their days staring at dull computer screens because it may make doing so less of a chore. [R]
Theoretically, Nefiracetam prolongs the eyelid heaviness and tiredness linked to the aforementioned scenario.
Even though the possible benefits of Nefiracetam for clear vision are interesting, it is important to remember that the substance is only meant for study and should not be used to treat yourself. Continued research and scientific study are needed to fully understand how Nefiracetam affects how the brain processes visual information and to find out how it might be used to improve vision.
Brain health is a vital aspect of overall well-being, and Nefiracetam has shown potential in promoting and safeguarding neuronal health in various neurological conditions. Illnesses such as Parkinson’s, Alzheimer’s, Huntington’s, stroke, brain injury, and spinal cord injuries can lead to the loss of brain cells. Nefiracetam has been found to play a protective role by increasing the production of nerve growth factor (NGF), which supports healthy cell growth in the brain’s activated neuron . [R]
Furthermore, Nefiracetam may hold promise in the treatment of cerebrovascular diseases. Clinical trials have demonstrated that this research compound has the ability to enhance blood flow to the brain, thereby providing it with vital oxygen and nutrients necessary for optimal brain function [R]. By improving cerebral blood flow, Nefiracetam may contribute to the maintenance of a healthy brain and potentially aid in the management of cerebrovascular conditions.
Remember, Nefiracetam is intended solely for research purposes and is not approved for human consumption.
The information presented here is for educational purposes only and should not be construed as medical advice. Nefiracetam is intended for laboratory research use only and is not intended for human consumption.
Potential side effects
There are various negative effects to be cautious of even if Nefiracetam has no dangerous side effects.
The most typical side effects include headaches, nausea, agitation, and anxiousness. [R]
According to toxicity studies done on the medication, this investigational treatment may also cause testicular toxicity. [R]
Nefiracetam’s potential impact on testicular hormone levels in animal test subjects was examined in a specific study involving a particular breed of dogs. [R]
Nefiracetam needs more study before it can be said to be safe for people to take, even though it is impossible to say for sure that the effects of the drug on dogs will be the same on people.
What is the molecular weight of Nefiracetam?
Nefiracetam has a molecular weight of 246.3 and is a fat-soluble nootropic. It has the chemical formula C14H18N2O2.
Where can I Buy Nefiracetam?
RCD.bio offers Nefiracetam for laboratory research use only.
When looking to purchase pharmaceutical intermediates or organic intermediates like Nefiracetam, it is essential to find a trustworthy seller that offers high-quality products. RCD.bio is a reliable source that provides Nefiracetam specifically for laboratory research use only.
At RCD.bio, we understand the importance of product quality and transparency. That’s why we ensure that every Nefiracetam purchase is accompanied by a Certificate of Analysis, which is issued by a third-party. This certificate verifies the identification, purity, and concentration of our Nefiracetam product, giving you confidence in the integrity of your research materials.
RDC. Bio also offers Nefiracetam powder form available in 5g and 10g.
Nefiracetam powder provides precise dosage control, making it perfect option for studies requiring specific dosages or customized formulations. It also offers faster absorption and onset of action, potentially beneficial for time-sensitive cognitive evaluations. However, the bitter taste of the powder may affect test subjects, which can be mitigated by using tablets that are tasteless and easier to administer. Ultimately, the choice between powder form and tablet form of Nefiracetam depends on the specific purpose of your research or experiment, enabling you to select the most suitable form for your need
Nefiracetam, a powerful nootropic drug belonging to the racetam family, is considered more effective than Piracetam, the original racetam. Originally developed in Japan during the 1990s for the treatment of cerebrovascular diseases, Nefiracetam has been found to have significant cognitive-enhancing properties. Research on animals suggests that it offers neuroprotective and nootropic benefits when used over a long period of time. The neuro-regulatory effects of Nefiracetam involve enhancing both GABAergic and cholinergic transmission, which contributes to its wide range of mental health advantages. These include reducing apathy, improving thinking and long-term memory, alleviating anxiety and depression, increasing the production of nerve growth factor, and providing anxiolytic effects.
Common side effects of Nefiracetam include headaches and nausea, which may be due to choline insufficiency. Other minor adverse effects may include agitation, anxiety, upset stomach, tiredness, dizziness, and diarrhea. However, long-term studies on humans and primates have shown that Nefiracetam is generally safe.
Nefiracetam should be taken with a meal that contains healthy fats or with a tablespoon of plant extracts such as expeller-pressed cold-pressed coconut or olive oil to enhance rapid absorption. Nefiracetam might increase the need for choline in the brain, hence it is advised to stack it with a reliable choline source like Citicoline or Alpha GPC.
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PLEASE NOTE: All products offered by RCD.bio are strictly intended for laboratory and research purposes only. They are not intended for use on animals or humans.