Nicotinamide Riboside

Nicotinamide riboside (NR) is a molecule that can be converted into nicotinamide adenine dinucleotide (NAD+), a coenzyme essential for cellular energy production. NAD+ is involved in numerous metabolic processes, including the transfer of electrons in cellular respiration, the breakdown of glucose and fatty acids, and DNA repair.

NR is a form of vitamin B3 that has gained attention for its potential benefits in promoting healthy life and aging, akin to the anti-aging supplements marketed today. It is believed that supplementing with NR can help maintain and restore NAD+ levels, which naturally decline with age. By increasing cellular energy production, NR may support overall health and vitality, as well as improve exercise performance and recovery.

Despite the alleged health benefits of NR, it is not a recommended NAD supplement and it needs to be evaluated by the Food and Drug administration regarding its efficacy on the human body. For this reason, people should not rely solely on this research chemical for their well-being since it is not designed to diagnose treat cure or prevent any illnesses.

Nicotinamide Riboside Product Details

One of the most promising benefits of NR is its potential in preventing or slowing the progression of age-related diseases, such as Alzheimer’s disease. NAD+ plays a critical role in maintaining cellular health and reducing oxidative stress, which are key factors in the development of neurodegenerative diseases.

  • CAS Number: 1341-23-7
  • Molar Mass: 255.25 g/mol
  • Chemical Formula: C11H15N2O5+
  • IUPAC Name: (2S,3S,4R)-2-[[(2R,3R,4S,5R)-3,4-dihydroxy-5-[6-(hydroxyamino)-6-oxohexyl]oxolan-2-yl]methylamino]-3,4-dihydroxybutanoic acid
  • Also known by Synonyms: NR Nicotinamide riboside chloride, Pyridinium, 3-(aminocarbonyl)-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-[6-(hydroxyamino)-6-oxo- hexyl]-2-tetrahydrofuranyl]-chloride 1-(β-D-Ribofuranosyl)nicotinamide chloride, Niagen, Tru Niagen, and ChromaDex NR

Nicotinamide riboside (NR) is a compound that has been studied in animals for its potential health benefits. To date, we have very few human trials of NR, meaning it is not safe for human consumption. Purchase NR for research purposes only.

Key Features

  • 98% purity
  • 9 g
  • Potential NAD+ booster
  • Sold for research purposes only

Potential Benefits of Nicotinamide Riboside 

As the majority of studies regarding nicotinamide riboside and NAD+ are conducted on animals, it is difficult to draw definite conclusions on its efficacy for humans. Nonetheless, there are some plausible health advantages associated with nicotinamide riboside.

Nicotinamide Riboside and Cellular Energy Production

One of its most important functions is its ability to increase NAD+ levels in cells, which is essential for the proper functioning of oxidative metabolism. NAD+ is a coenzyme that is involved in many cellular processes, including energy production, DNA repair, and the regulation of cellular signaling pathways. As we age, our NAD+ levels tend to decline, which can lead to a variety of health problems. [R]

Nicotinamide Riboside and Brain Health

Some preliminary research has suggested that Nicotinamide Riboside NR may protect neurons and contribute to the growth and development of neural tissue. In older mammals, NR may help to maintain the cellular function of neural stem cells. This is particularly relevant to the aging population, where age-related cognitive decline is a major concern. While the data from animal studies are promising, it is important to note that the efficacy of NR in humans for brain health is still uncertain. [R]

Nicotinamide Riboside and Healthy Aging

By increasing NAD+ levels in the body, Nicotinamide Riboside NR may activate enzymes that promote healthy aging. This is because NAD+ is involved in many cellular repair processes and plays a critical role in maintaining the health of our cells. Additionally, increasing NAD+ levels in the body may help to support our innate immunity, which becomes less efficient as we age. Therefore, NR may be beneficial for overall longevity. [R] [R]

Nicotinamide Riboside and Heart Health

Studies on animals have shown that increasing NAD+ levels may help reverse age-related vascular changes and reduce aortic stiffness, lower systolic blood pressure among adult mammals at risk of high blood pressure, and improve heart health. This suggests that Nicotinamide Riboside NR may have potential applications in supporting cardiovascular health, although more research is needed to confirm its efficacy in humans. [R]

Nicotinamide Riboside and Circadian Rhythms

Another potential benefit of Nicotinamide Riboside NR is its ability to regulate circadian rhythms. By increasing NAD+ levels, NR may help the body to regulate its internal clock, which could be useful for treating jet lag and other circadian rhythm disorders. [R]

Nicotinamide Riboside and Weight Management

While Nicotinamide Riboside NR has been shown to speed up metabolism in mice, its effects on humans are still uncertain. More research is needed to determine whether NR would be an effective weight management tool in humans. [R]

Nicotinamide Riboside and Muscle Function

Nicotinamide Riboside NR may be beneficial for improving muscle function and exercise performance in older adults. By increasing NAD+ levels, NR may help to improve muscle strength and endurance, allowing older adults to exercise more effectively. This may be particularly useful in improving the quality of life in older adults. [R] [R]

Overall, while the benefits of NR are generally recognized, it is important to remember that most of the research has been conducted on animals, and more studies are needed to confirm the efficacy of NR in humans. Nevertheless, NR is a research chemical that could encourage healthy cellular metabolism, brain health, cardiovascular health, weight management, and muscle function in older adults.

How It Works

Nicotinamide riboside (NR) is a form of vitamin B3 that is converted into nicotinamide adenine dinucleotide (NAD+) in the body. NAD+ is a coenzyme involved in many cellular processes, including energy production, DNA repair, and cell signaling. By increasing NAD+ levels, NR can support good health and potentially extend lifespan.

NR is a precursor to NAD+, which means that it is used by the body to make NAD+. This is important because NAD+ levels naturally decline with age, and this decline has been linked to a range of age-related diseases, including Alzheimer’s disease. By supplementing with NR, it is possible to support NAD+ levels and potentially reduce the risk of age-related disease.

The scientific basis behind the benefits of NR lies in its ability to support energy production in cells. NAD+ is an essential component of the process by which cells generate energy, and by supporting NAD+ levels, NR can help maintain cellular energy production. This is particularly important in tissues with high energy demands, such as the brain and skeletal muscle.

In addition to supporting energy production, NR may also have other benefits for health. For example, it has been shown to reduce inflammation and improve insulin sensitivity. It may also play a role in protecting against age-related disease by reducing oxidative stress and supporting DNA repair.

Precautions

While Nicotinamide riboside (NR) is generally considered safe for most test subjects, it could still lead to certain side effects.

Firstly, it is important to note that NR is not intended to diagnose, treat, or cure any disease. It is a form of vitamin B3 that is found in small amounts in foods like milk and beer, and it can also be synthesized in the body.

Individuals who are pregnant or breastfeeding should avoid consuming high doses of NR, as there is limited research on its safety in these populations.

Additionally, the appropriate dosage of NR may vary depending on a test subject’s age, weight, and overall health status. It is recommended to start with a lower dosage and gradually increase over time, up to a maximum of one capsule daily.

Those who have a history of skin cancer or who are at risk of developing skin cancer should avoid NR, as it may increase the risk of skin cancer.

NR may also interact with certain medications, such as blood thinners or chemotherapy drugs. Individuals who are taking medications should consult with their healthcare provider before consuming NR.

Lastly, it is important to note that NR is absorbed by the body differently than other forms of vitamin B3.

Potential Side Effects

Throughout multiple research studies, no significant negative reactions were observed from the use of NR. However, some mild side effects were reported in certain instances, which included:

  • Nausea
  • Muscle soreness and cramps
  • Increased bruising
  • Elevated blood pressure

Conclusion

Nicotinamide riboside (NR) has been evaluated for its potential health benefits, including its effects on cellular processes, stress, sleep, and longevity. While it should not be relied upon solely to treat any medical condition, incorporating NR into a daily regimen may provide some benefits.

NR can be found in small amounts in foods such as milk and beer and can also be synthesized in the body. The appropriate nicotinamide riboside dosage may vary depending on the test subjects’ age, weight, and overall health status. It is recommended to start with a lower amount and gradually increase over time, up to a maximum of one capsule daily.

NR is a precursor to nicotinamide adenine dinucleotide (NAD+), an important enzyme involved in cellular energy production. By increasing NAD+ levels, the research chemical may help support healthy aging and longevity.

In addition, NR has been shown to have anti-inflammatory effects and may help reduce oxidative stress, which can contribute to a variety of health issues. Some studies have also suggested that NR may improve sleep quality and reduce feelings of stress and anxiety.

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