Orlistat is an FDA-approved medication that is sold under the name of Xenical or Alli orlistat. [R]
Alli orlistat 60 mg capsules weight loss aid is used by overweight adults following a low-fat, reduced-calorie diet. This weight loss supplement supposedly inhibits enzymes that break down dietary fats, leading to minimal fat absorption. This promotes weight loss and has few systemic side effects. However, the diet pill may cause digestive issues like oily stools and increased bowel movements.
Orlistat Product Details
Orlistat, also known as Tetrahydrolipstatin, is available as a prescription medication under the brand names Xenical or Alli diet pills. The weight loss aid refill inhibits pancreatic and gastric lipases, essential enzymes for fat absorption, by binding to their active sites. The process prevents the breakdown of dietary fats and reduces calorie intake. Orlistat specifically targets the gastrointestinal tract, with negligible effects on other enzymes.
- CAS Number 96829-58-2
- Molar Mass 495,735 g/mol-1
- Chemical Formula C29H53NO5
- IUPAC Name (2S)-2-[(1R)-1-hydroxy-2-[(2S)-5-oxooxolan-2-yl]ethyl]octanoic acid
Key Features of Orlistat
- 98% Purity
Potential Benefits of Orlistat
Orlistat and Cancer
Orlistat has demonstrated potential as an anticancer compound, showing inhibition of endothelial cell proliferation, angiogenesis, and FAS activity in various cancer cells. Further clinical research is needed to explore its potential as an anti-tumor drug. [R]
Orlistat’s Effect on Weight Loss
Diet and exercise are the necessary starting points of any weight loss program. Orlistat is an FDA-approved weight loss supplement that could expedite such an endeavor.
Long-term studies have confirmed that orlistat leads to significant diet weight loss. When taken with a well-balanced, low-calorie, low-fat diet, orlistat (120 mg, taken with major meals) can prevent the absorption of about 30% of dietary fat, equivalent to approximately 200 additional calories. Combining orlistat with an energy-restrictive diet has been shown to result in more weight loss compared to a placebo with energy restriction. [R] [R]
Studies have demonstrated weight loss ranging from 8.76 kg to 9.2% over one year. Meta-analyses have shown a mean weight loss of 2.9 kg over 12 months of treatment. Orlistat has also been found to prevent weight gain in the long term, even without a controlled-energy diet. It has been approved by the FDA for the treatment of childhood and adolescent obesity. [R] [R] [R]
Orlistat and Cardiovascular Diseases
Orlistat has been found to improve lipid profiles and lower blood pressure, which are risk factors for cardiovascular disease associated with obesity. It has shown positive effects on parameters such as apolipoprotein B, total cholesterol, LDL cholesterol, triglycerides, and the LDL-to-HDL cholesterol ratio. [R]
Orlistat and Diabetes
Orlistat treatment, in combination with diet, has shown improvement in glycemic control in obese test subjects with type 2 diabetes. Studies have demonstrated clinically meaningful weight loss and maintenance, along with decreases in HbA1c, fasting plasma glucose, and oral sulfonylurea medication dosages. [R] [R]
Orlistat and Binge Eating Disorder
Orlistat, when combined with a mildly reduced-calorie diet, has been shown to lead to significant weight loss and lower scores on the Eating Disorder Inventory 2 in test subjects with binge eating disorder. [R]
Orlistat and Knee Osteoarthritis
It is alleged that Orlistat combined with a low-calorie diet has been more effective in reducing weight compared to a low-calorie diet alone. Certain research studies have shown the potential to reduce the clinical progression of knee osteoarthritis, as indicated by decreased WOMAC pain scores. [R]
How It Works
Orlistat, when absorbed, acts as an inhibitor of pancreatic and gastric lipases, which are enzymes responsible for breaking down dietary fats. By binding to the active sites of these lipases, Orlistat prevents the hydrolysis of triacylglycerols (TGs) into absorbable fatty acids and monoacylglycerols.
Orlistat inhibits the absorption of approximately 25% of the fat consumed by the intestines. Unabsorbed fats are expelled from the body during bowel movements As a result, the absorption of dietary lipids is hindered, leading to a decrease in calorie intake. Orlistat specifically targets the gastrointestinal tract and has minimal impact on other enzymes.
When using Orlistat, it is important to take certain precautions. First, it is essential to follow a low-fat diet while using Orlistat. This medication works best when combined with a balanced eating plan that includes reduced-calorie and low-fat meals. Additionally, it is important to be aware of potential digestive system side effects associated with orlistat. These can include oily stools, increased bowel movements, and flatulence. While these effects are usually temporary and manageable by reducing dietary fat intake, it is important to be prepared for such potential discomfort.
When purchasing a weight loss product, carefully read the labels to ensure that orlistat is the active ingredient. Pay attention to the dosage instructions and follow label directions. Orlistat is intended for use by overweight adults who are actively working towards losing weight through lifestyle changes and dietary modifications. It is not intended for individuals seeking cosmetic weight loss or as a substitute for healthy habits.
Potential Side Effects
Orlistat is generally considered safe when used as directed. However, like any medication, it can cause side effects. The most common side effects include gastrointestinal issues such as oily stools, increased bowel movements, and flatulence. These effects are often temporary and can be managed by following a low-fat diet. In rare cases, severe liver injury has been reported, so it is important to seek medical attention if you experience symptoms such as dark urine, yellowing of the skin or eyes, or persistent nausea. It is advisable to consult with a healthcare professional for personalized advice and monitoring while using Orlistat.
In conclusion, Orlistat serves as a valuable weight loss aid when used as part of a comprehensive weight loss program. As a lipase inhibitor, it helps block the absorption of dietary fat in the digestive tract, allowing unabsorbed fat to be excreted. By following label directions and incorporating Orlistat into a healthy diet and exercise routine, it can be an effective weight loss pill for individuals seeking to shed extra pounds. Its specific mechanism of action, minimal absorption, and direct effects on specific enzymes make it a smart edge for weight management.
Orlistat’s ability to prevent the absorption of about 30 percent of the fat consumed acts as a starting point for achieving weight loss goals. It is the only FDA-approved over-the-counter weight loss pill with proven efficacy. Incorporating Orlistat into a weight loss program can help individuals reduce calorie intake and promote fat loss, providing an added advantage in their journey towards a healthier weight.
In summary, Orlistat is an effective weight loss aid that helps individuals stay on track with their diet and weight loss journey. With its minimal absorption and direct effects on fat metabolism, it provides a smart edge for those seeking to achieve their weight loss goals.
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