PAL-GHK
Introduction
PAL-GHK, also known as Pro-vitamin A or palmitoyl oligopeptide and palmitoyl tetrapeptide-3, has been found to have significant benefits for the skin. Pal-GHK is a hybrid peptide made up of one fatty acid and one peptide. Studies have shown that it can potentially help treat or improve the appearance of skin issues such as acne, stretch marks, scarring, and wrinkles.[R] It produces collagen and boosts the skin’s general suppleness by upregulating the skin’s extracellular matrix [R]
This peptide works by promoting the synthesis of collagen and elastin, two proteins that are essential for healthy and elastic skin. By stimulating the production of these proteins, PAL-GHK can help reduce the appearance of wrinkles and fine lines, improve skin texture, and enhance overall skin health.[R]
Key Features
rcd.bio offers PAL-GHK with the following specifications:
- A purity of 98%, verified by third-party laboratory testing.
- Available in 10mg powder form.
How PAL-GHK Works?
An adhesion molecule called PAL-GHK (PGH) helps calcium phosphate crystals stick together. To describe its function in the mineralization process, extensive research has been conducted on it. PGH promotes adhesiveness and the stability of crystalline formations, playing a crucial part in adhesion processes. In addition to contributing to inflammatory processes and wound healing, these adhesion molecules also bind integrin molecules.
The Palmitoyl Peptide’s most well-known effect is that it promotes collagen synthesis and development in the dermal layers of the skin, ultimately leading to a more youthful appearance [R].
PGH is particularly good in repairing collagen degradation that develops over time due to environmental stressors like aging, and exposure to ultraviolet (UVA) light, radiation, and other pollutants. Palmitoyl tripeptide 1 facilitates cell attachment to collagen molecules, which promotes collagen synthesis and keeps skin moisturized and firm while minimizing wrinkles and other outward symptoms of aging [R].
Aging skin loses its natural elasticity and firmness, resulting in the appearance of wrinkles, fine lines, and sagging. To combat these signs of aging, scientists have been studying the use of Palmitoyl Peptide, specifically the adhesion molecule PAL-GHK (PGH), to promote collagen synthesis and skin rejuvenation.[R] Palmitoyl Peptide is a small molecule composed of amino acids that can penetrate the skin’s dermal layers and stimulate the production of collagen. [R]. Collagen is a protein that gives our skin its strength and elasticity, treating aged skin leading to wrinkle reduction, and enhancing skin strength,
Palmitoyl tripeptide 1, a component of PGH, facilitates cell attachment to collagen molecules, promoting collagen synthesis and keeping the skin moisturized and firm while minimizing wrinkles and other outward signs of aging. This is particularly effective in repairing collagen degradation that occurs due to environmental stressors like aging, exposure to ultraviolet (UVA) light, radiation, and pollutants.[R].
The scientific basis behind the benefits of PAL-GHK
Over the years, PAL-GHK peptide has been the subject of numerous experiments. The following have shown positive effects.
Collagen Formation
Collagen is a protein that provides structure and elasticity to our skin, but as we age, our bodies produce less of it, leading to the appearance of wrinkles and dryness. Research has shown that it can possibly initiate relief from inflammation, softening of wrinkles, improved elasticity and texture, and increased collagen and elastin production.[R].
Additionally, Palmitoyl tripeptide 1 has been found to protect against collagen loss caused by external influences such as smoking and air pollution. This makes it an important support for collagen maintenance and regeneration in healthy skin cells, ultimately leading to a healthier complexion with enhanced tone and texture.[R].
Dermal Skin Layers
Proteins found in the dermal skin layers, like collagen and elastin, deteriorate over time and cause wrinkles and dryness [R]. According to studies, palmitoyl tripeptide 1 improves skin hydration when applied topically because it stimulates collagen, connective tissues, and elastin in the skin [R]. This shows it is possible to use it as a topical peptide treatment for skin problems.
Furthermore, it boosts the activity of numerous antioxidant genes that support a healthy epidermis. The end result is skin that appears smoother, firmer, and healthier-looking with fewer wrinkles [R].
Wound Healing
Peptides such as PAL-GHK (PGH) have been found to speed up the skin repair process by inducing an inflammatory response, raising epidermal growth factors, promoting collagen formation, and enhancing tissue defense. PGH significantly accelerates the healing process of wounds by triggering cellular and molecular cascades. [R].
The process of wound healing is complex and requires precise interactions between elements of the extracellular matrix and cell-derived substances. However, studies have shown that PGH plays a crucial role in this process, making it an important component in wound healing and skin regeneration[R].
Precautions
This is not intended to be considered as medical advice and is only being supplied for educational and scientific research. Pal-GHK is only to be used in labs and for study; they are not intended for human consumption.
The FDA has approved Pal-GHK (Palmitoyl Tripeptide-1) to be safe for usage in cosmetic goods in a safety evaluation study and is regarded as safe. [R] [R] [R]
Although there is no specific evidence regarding the hazards of a low level of PAL-GHK, it is crucial to use cosmetic products containing Pal-GHK according to the advised dosage and usage. [R] [R] [R]
Potential side effects
In one study, it has revealed no evidence of side effects of palmitoyl tripeptide-1 (Pal-GHK) [R]. In another study, Pal-GHK as one of the synthetic peptides may irritate the skin. Further, there is no precise information available. It is significant to highlight that the studies cited are constrained, and additional analysis is required to identify any potential negative effects of PAL-GHK. [R]
Where Can I Buy the Best PQQ?
rcd.bio offers PAL-GHK for laboratory research use only.
When buying PAL-GHK, it is important to choose a reputable seller who provides quality products. At rcd.bio, each product is accompanied by a third-party-issued Certificate of Analysis showing the identification, purity, and concentration of our product.
Conclusion
It has been demonstrated that the peptide PAL-GHK, which is generated from palmitoyl-lysine-glycine-histidine-lysine, is beneficial for skin care. Studies on PAL-GHK’s impact on the stratum corneum have shown that this compound helps to promote the synthesis of collagen while also offering excellent moisturization and further barrier protection.
PAL-GHK is made up of residues of palmitic acid, lysine, glycine, and histidine, which are arranged in a certain order that enables it to self-assemble into a more effective form without the need for other components.
Through the metal-ion-dependent structure that helps to increase collagen formation and improve barrier restoration abilities, PAL-GHK nourishes the skin as it penetrates the stratum corneum. The mechanism of action of PAL-GHK has been further studied in subsequent research on the self-assembly process and the positive effects such as improving discolored skin and repair photoaged skin
Disclaimer
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PLEASE NOTE: All products offered by rcd.bio are strictly intended for laboratory and research purposes only. They are not intended for use on animals or humans.
