Picamilon is a highly regarded nootropic compound that has gained recognition among researchers for its potential therapeutic applications in Russia. Primarily being studied for the management of stress, anxiety, and other neurological conditions, this compound combines the inhibitory neurotransmitter GABA with vitamin B3 (Niacin). One of its unique attributes is its ability to potentially traverse the blood-brain barrier, an accomplishment that GABA alone cannot achieve.

Extensive preclinical studies have demonstrated promising results regarding the effects of Picamilon. It shows potential in reducing anxiety- and depression-related behaviors, enhancing both short- and long-term memory, and shielding neurons from excitotoxicity, which can cause damage. Furthermore, Picamilon allegedly exhibits the ability to augment cerebral blood flow and provide protection against nerve inflammation. These findings further contribute to its growing reputation as a valuable research compound with potential cognitive benefits.

Despite the mentioned potential health advantages, Picamilon is recognized as a research chemical. Buy Picamilon for research use only.

Picamilon Sodium Nicotinoyl – GABA Product Details

Picamilon, a nootropic initially developed in the former USSR, has been designed with the intention of potentially augmenting GABA activity within the brain. While it has gained recognition as a prescription compound for the treatment of neurological conditions such as stress and anxiety in Russia, it has not been approved in the United States.

Picamilon is composed of a combination of gamma-aminobutyric acid (GABA) and nicotinic acid (vitamin Niacin). GABA acts as a neurotransmitter responsible for transmitting chemical messages throughout the brain and nervous system. An interesting characteristic of Picamilon is its potential to cross the blood-brain barrier, which is not achievable by GABA alone.

Niacin, or vitamin B3, serves various essential functions in the body, including DNA repair and the synthesis of fats and cholesterol. Additionally, Niacin acts as a vasodilator. While natural food sources such as fish, beef, and seeds contain Niacin, the body does not produce it on its own, unlike GABA.

The combination of Niacin with GABA is the key factor enabling Picamilon to potentially penetrate the blood-brain barrier and exert the effects associated with this particular nootropic compound.

  • CAS Number 34562-97-5
  • Molar Mass 208.217 g·mol−1
  • Chemical Formula C10H12N2O3
  • IUPAC Name 4-(Pyridine-3-carbonylamino)butanoic acid
  • Synonyms: Pikamilone sodium, pikamilone sodium salt, sodium 4-(nicotinamido)butanoate, butanoic acid sodium salt

Key Features of Picamilon Sodium Nicotinoyl – GABA for Sale

  • 98% Purity
  • 5000mg
  • Sold for research use only

Potential Benefits of Picamilon Sodium Nicotinoyl – GABA

Picamilon and Memory

While limited research has been conducted on the effects of Picamilon on memory, a preclinical study demonstrated its potential in improving short- and long-term memory. Additionally, the study found that Picamilon enhanced navigation abilities in animals. However, it is important to note that the study involved a combination of Picamilon, piracetam (another nootropic), and tacrine (a medication for mild to moderate dementia) to achieve these effects. [R]

Picamilon and Vision Disorders

Studies have investigated the potential benefits of Picamilon in the treatment of vision disorders. In one clinical study involving 60 test subjects with macular degeneration, three months of Picamilon treatment showed positive results in improving visual acuity and peripheral vision. These beneficial effects suggest the probability of Picamilon in managing macular degeneration. [R]

Another study focused on central chorioretinal dystrophy, a condition that leads to progressive vision loss. In this study, Picamilon demonstrated improvements in visual acuity, peripheral vision, and a reduction in glaucoma severity among the 48 clinical test subjects involved. [R]

Picamilon and Disadaptation Syndrome

Disadaptation syndrome, characterized by disequilibrium and gait modifications, can affect postural reactions and increase the fear of falling. Picamilon, phenibut, and aminalon were tested in a preclinical study on test subjects with disadaptation syndrome. The study suggested that these compounds potentially led to a decrease in blood filling of the brain and increased blood flow from the brain, indicating their potential in managing disadaptation syndrome. [R][R]

Picamilon and Neuroprotection

Various preclinical studies have highlighted the neuroprotective properties of Picamilon. It has shown the potential to protect brain cells from excitotoxicity, a condition where excessive activation leads to cell death. Additionally, Picamilon has been found to enhance mitochondrial function in neurons and protect immune and brain cells from oxidative stress and membrane damage. [R][R]

Furthermore, studies have indicated that Picamilon may help normalize serotonin and dopamine levels in brain regions associated with Parkinson’s disease. [R]

Picamilon and Diabetic Neuropathy

In animal studies, Picamilon has demonstrated the potential in reducing inflammation of nerves and partially lowering brain sorbitol levels in mice with diabetic neuropathy. These findings suggest a role for Picamilon in preventing and treating this condition, which involves nerve damage resulting from diabetes. [R][R]

Picamilon and Anxiety and Depression

Animal studies have provided insights into the potential anxiolytic and antidepressant effects of Picamilon. These studies have demonstrated that Picamilon can reduce anxiety- and depression-related behaviors in rats, potentially through its activation of GABA-A receptors. GABA, as the chief inhibitory neurotransmitter in the brain, counteracts the effects of anxiety-causing neurotransmitters like glutamate. [R][R]

Moreover, Picamilon has been shown to suppress responses to disturbing stimuli, suggesting a potential reduction in anxiety response. [R]

The research compound is believed to address depression caused by alcohol withdrawal syndrome.

Picamilon and Cerebral Blood Flow

Maintaining proper cerebral blood flow is crucial for overall brain health and can help prevent serious conditions such as stroke. Preclinical studies have consistently shown that Picamilon has the potential to enhance blood flow throughout the brain. In a comparative study conducted in 1989, Picamilon was found to have a more substantial effect on blood flow compared to other nootropics like piracetam. [R]

Another study conducted in 2005 indicated that Picamilon’s ability to increase cerebral blood flow may be attributed to its activation of chloride channels in GABA receptors. [R]

How It Works

Preclinical investigations have revealed that once Picamilon enters the brain, it undergoes enzymatic breakdown into its constituent components: GABA and niacin. GABA is believed to exert its effects by activating both GABA receptor subtypes, namely GABA-A and GABA-B receptors. On the other hand, niacin has been shown to possess vasodilatory properties, leading to increased blood flow throughout the brain.

Furthermore, studies conducted on animals have provided evidence supporting the potential of Picamilon to enhance cerebral blood flow. Additionally, the nootropic properties of Picamilon have been observed in rat models, demonstrating its ability to activate GABA receptors and potentially alleviate anxiety- and depression-related behaviors.


When researching the use of Picamilon Sodium Nicotinoyl GABA, it is essential to take certain precautions. Here are some precautions to keep in mind:

Observe best practices for studying research chemicals: Studying research chemicals requires a responsible and informed approach to ensure safety and meaningful scientific exploration. Research chemicals, also known as designer drugs or experimental compounds, are substances synthesized for scientific investigation or exploration of their properties.

Follow recommended dosage: Adhere to the recommended dosage instructions outlined on the product label. Avoid exceeding the suggested dose to minimize the risk of potential adverse effects among test subjects.


In conclusion, the use of Picamilon Sodium (also known as Nicotinoyl-GABA, Pikamilon Sodium Salt, or Nicotinoyl GABA Sodium Salt) offers a range of benefits that stem from its unique molecular composition. This synthetic combination of the inhibitory neurotransmitter GABA and the essential vitamin Niacin (Vitamin B3) has shown potential in various clinical studies and research investigations.

One of the alleged primary advantages of Picamilon Sodium is its ability to enhance cerebral circulation and blood supply to the brain. This is achieved through the vasodilatory effects of Niacin, which acts to dilate blood vessels and promote improved blood flow. This property makes Picamilon Sodium a valuable candidate for addressing conditions associated with compromised cerebral blood flow, such as brain trauma and gravitational exposures.

Additionally, Picamilon Sodium has demonstrated the potential to lower blood pressure, induce muscle relaxation, and promote mood improvement. These effects are attributed to the combined actions of GABA and Niacin, which work synergistically to modulate neurotransmission and energy metabolism within the brain.

Furthermore, Picamilon Sodium has shown potential in improving memory function, making it a possible therapeutic option for test subjects seeking cognitive enhancement. Its molecular structure and linked derivative of GABA contribute to its ability to support memory processes and neuronal function.

It is important to note that while the benefits of Picamilon Sodium are encouraging, further research is necessary to fully understand its mechanisms of action and its efficacy in various neurological conditions.


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PLEASE NOTE: All products offered by are strictly intended for laboratory and research purposes only. They are not intended for use on animals or humans.