Pregnenolone, a vital hormone powerhouse within our bodies, takes the lead in orchestrating the synthesis of essential hormones such as estrogen, progesterone, cortisol, and testosterone. Emerging from key organs such as the adrenal glands, liver, skin, brain, testicles, and ovaries, this versatile neurosteroid has become the focal point of intense research, unveiling a plethora of potential applications. Join us as we unravel the captivating findings that shed light on pregnenolone’s impact on cognition, memory, neuroprotection, mood regulation, anti-inflammatory prowess, and pain relief. This exploration is purely centered on research, offering a fascinating glimpse into the scientific intricacies of pregnenolone without delving into any considerations of personal use. Get ready for a compelling journey through the scientific wonders of this extraordinary hormone!

Key Features

  • 98% Purity
  • Sold for research purposes only and not for human consumption
  • Offered in Capsules, Tablets, Nasal Spray, and Powders.

What is Pregnanolone?

Pregnenolone (3a-hydroxy-5b-pregnan-20-one) functions as a progesterone metabolite, influencing the activity of gamma-aminobutyric acid (GABA) receptors at both synaptic and extrasynaptic sites within the GABAA system.[R] Pregnenolone stands out as a prominent neurosteroid, serving as the precursor to all other neurosteroids present in the brain. Its impact extends to crucial aspects like myelination, neuroinflammation, neurotransmission, and neuroplasticity, showcasing its significance in cognition, aging, and addiction. Research has highlighted altered pregnenolone levels in mental and pain disorders, shedding light on the therapeutic potential of pregnenolone adjunct therapy in these conditions. This evidence underscores the therapeutic possibilities associated with pregnenolone.[R]

Pregnanolone Potential Benefits

Numerous animal and human studies have been conducted on the potential application of Pregnanolone. Below are some of the relevant findings:

Pregnanolone on Stress

In a recent study diving into the impact of female hormones on stress resilience and defense against free radicals, researchers made intriguing discoveries. Female rats, subjected to stress by inhaling CO2 after having their ovaries removed, exhibited increased signs of brain damage from free radicals. However, a ray of hope emerged when these rats were administered pregnanolone, a hormone. Surprisingly, pregnanolone acted as a safeguard, protecting their brains from such damage. This intriguing finding hints at the potential protective role of female hormones against oxidative stress, with pregnanolone standing out as a promising treatment avenue for this specific type of stress.[R]

It is important to note that Pregnanolone on stress was conducted in female rats only, further research should be done.

Pregnanolone on Cognition

Recent research shed light on the impact of diet-induced obesity in mice, revealing potential drawbacks for both metabolism and cognition. The study honed in on the hypothalamus, a critical brain region governing metabolism and cognition, and identified reduced pregnenolone levels in mice with diet-induced obesity. This decline in pregnenolone correlated with a noticeable decline in cognitive function among the mice. In a bid to explore pregnenolone’s role in memory performance, the researchers administered pregnenolone to the mice, and the outcomes were promising. Supplementation with pregnenolone demonstrated an improvement in recognition memory, hinting at its therapeutic potential for enhancing cognitive function, particularly in individuals grappling with metabolic disorders.[R]

It’s important to note that this study was conducted in mice, so the results may not necessarily apply to humans thus rigorous scientific research is suggested.

Pregnanolone on Learning and Memory

Exploring the effects of PREGS and DHEAS on age-induced learning impairment in 16-month-old mice, this study employed the step-down type of passive avoidance. In this test, older mice exhibited lower step-down latency than their 3-month-old counterparts, indicating retention issues in aged mice. However, pretraining injections of PREGS or DHEAS (1-20 mg/kg, s.c.) demonstrated a dose-dependent enhancement of 24-hour delay retention performances in this task among aged mice. The most significant effects were observed with a PREGS dose of 5 mg/kg and a DHEAS dose of 10 mg/kg.

These findings suggest that the treatment of PREG, DHEA, and their sulfate esters holds promise in supporting youthful memory and cognition in middle-aged and elderly animals, addressing common issues related to mental focus.[R]  

Pregnanolone Promotes Optimal Hormone Balance

As a vital precursor for cortisol, progesterone, and DHEA, subsequently convertible into essential hormones like estrogens and testosterone, pregnenolone emerges as a key player in sustaining hormonal equilibrium. The intricate system governing the body’s stress response finds balance through the utilization of pregnenolone. For individuals identified with hormone deficiencies via thorough testing or those seeking assistance in balancing cortisol to DHEA, pregnenolone supplements prove invaluable for restoring youthful hormone levels. However, it’s crucial to emphasize that this study necessitates thorough scientific scrutiny to firmly establish the efficacy of pregnenolone.

Pregnanolone on Cancer 

Allopregnanolone, a byproduct of progesterone breakdown in the body, has been under scientific scrutiny due to its potential applications in anxiety and depression treatment. This compound interacts with specific receptors in the brain, influencing the immune system and cellular growth. Intriguingly, recent studies have unveiled a dual role for allopregnanolone in cancer development. While low levels seem to facilitate the growth of various cancers, including breast cancer, ovarian, and glioblastoma, elevated amounts exhibit a contrasting effect by inhibiting this progression. This nuanced understanding sheds light on the complex interplay of allopregnanolone in physiological and pathological conditions. [R]

Pregnanolone on Traumatic Brain Injury

In a rat study, researchers found that when rats experienced a traumatic brain injury (TBI), it led to a lot of a couple of proteins (IL-1β and TNF-α) being released, causing swelling in the brain. This swelling could lead to permanent loss of brain cells and problems with memory and thinking. The study discovered that giving the rats progesterone and allopregnanolone right after the injury reduced the levels of these proteins. However, after a few hours, the protein levels went up again, but by the sixth day, they were back to normal. This suggests that progesterone and allopregnanolone might help with brain swelling and recovery right after a traumatic brain injury.[R]

It is important to note that the study mentioned above was conducted solely on laboratory rats and there is no limited study conducted to know possible life extension in humans.

 How Does Pregnanolone Work?

Pregnenolone has the important job of being the starting material for neurosteroids. These neurosteroids can then help regulate different neurotransmitter receptors like GABA-A and NMDA receptors. This can help with the brain’s ability to change and adapt to new information, which is important for learning and memory.[R]

Potential Side-effects of Pregnanolone Research

  • Dizziness or Drowsiness
  • Headaches
  • Mood Changes
  • Nausea or Upset Stomach
  • Sleep Disturbances
  • Hormonal Effects

Please note that these observations are based on research studies, and individual subject responses may vary. This information is provided for research purposes only.

Frequently Asked Questions

Can Pregnanolone impact hormonal balance?

Pregnanolone is a precursor to hormones, and research explores its potential effects on hormonal balance. However, individual responses may vary.

How does Pregnanolone relate to neuroprotection?

Studies suggest that Pregnanolone may have neuroprotective effects, particularly in conditions like Alzheimer’s disease, emphasizing its potential role in supporting brain health.

What is the mechanism of action of Pregnanolone?

Pregnanolone modulates the action of gamma-aminobutyric acid (GABA) at GABAA synaptic and extrasynaptic receptors, contributing to its potential neuroactive effects.

Can Pregnanolone be used to manage oxidative stress?

Some studies suggest that Pregnanolone may play a protective role against oxidative stress, potentially making it a candidate for managing conditions associated with oxidative damage.

Summary of Pregnanolone

Pregnenolone is a naturally occurring chemical in the body, known to impact brain function, and serve as a precursor to all neurosteroids present in the brain. Its influence extends to critical processes like myelination, neuroinflammation, neurotransmission, and neuroplasticity, implying a significant role in cognition, aging, and addiction. Research has indicated fluctuations in pregnenolone levels in conditions related to mental health and pain disorders. While some studies suggest therapeutic potential for a healthier and more enriched life, it’s important to note that scientific evidence supporting its use in conditions like autism, back pain, bipolar disorder, schizophrenia, and others is currently insufficient, distinguishing it from more established dietary supplements.


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