Galantamine Hydrobromide [Powder] – Product Details
What is Galantamine Hydrobromide Powder?
Galantamine is a reversible and competitive inhibitor of the enzyme acetylcholinesterase (AChE) and is approved for treating Alzheimer’s disease. It also acts as an allosteric modulator of nicotinic acetylcholine receptors (nAChR). By activating nAChR and increasing the expression of the anti-apoptotic protein Bcl-2, it can potentially prevent apoptosis and provide neuroprotection.
Naturally, Galantamine is classified as a tertiary alkaloid and was first discovered and isolated from plant sources like Galanthus nivalis in the early 1950s. Initially, it was studied for its effects on neuropathic pain and paralytic conditions such as post-polio paralysis, myopathies, and reversing neuromuscular blockade.
The remarkable discovery of Galantamine’s ability to inhibit acetylcholinesterase led to its exploration as a potential treatment for various psychiatric disorders. However, due to the challenges associated with extracting and synthesizing Galantamine, its reemergence as a therapeutic option for Alzheimer’s disease didn’t occur until the early 1990s. In 2001, it received FDA approval for the treatment of Alzheimer’s disease, ranging from mild to moderate to severe cases.
|Galantamine Hydrobromide Powder
|acetyl cholinesterase inhibitor
|Minimize open-air exposure, and store in a cool dry place
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