There are fascinating substances with enormous potential for research and discovery in the area of scientific study. Semax is one such substance that has received a lot of attention already. Originally developed as a neuropeptide to address circulatory disorders, Semax has found its place as a valuable research chemical. Derived from the 4-10 fragment of the adrenocorticotropic hormone (ACTH), Semax was first formulated in Russia during the 1980s. Initially designed to combat circulatory issues like heart attacks, strokes, and high blood pressure, this synthetic neuropeptide has shown promise in the field of acute cerebral hypoxia caused by traumatic brain injury.[R][R]

One intriguing aspect of peptide Semax affects brain chemistry. Research suggests that Semax has the ability to increase dopamine levels in the brain, which plays a crucial role in motivation, pleasure, and cognition. This property, coupled with its reported capacity to enhance memory and mental clarity, makes Semax a compound worth investigating further.

To further understand the scientific community’s enthusiasm for Semax and its prospective applications, we shall look into the results of the research in the following sections.


Key Features

RCD.Bio offers Semax with the following specifications:

  • A purity of 98%, verified by third-party laboratory testing.
  • Available in  30mg powder form


  • CAS Number: 4037-01- 8
  • Molar Mass: 813.93 g·mol−1
  • Chemical Formula: C37H51N9O10S
  • IUPAC Name: (2S)-1-[2-{[(2S)-1-[(2S)-2-{[2-{[(2S)-2-{[(2S)-2-amino-4-methylsulfanylbutanoyl]amino}-4-carboxybutanoyl]amino}-3-(1H-imidazol-5-yl)propanoyl]amino}-3-phenylpropanoyl]pyrrolidine-2-carbonyl]amino}acetyl]pyrrolidine-2-carboxylic acid
  • Synonyms: L-Methionyl-L-α-glutamylhistidyl-L-phenylalanyl-L-prolylglycyl-L-proline, (Pro8,Gly9,Pro10)ACTH-(4-10)


How Semax Works?

We don’t fully understand how Semax works because there hasn’t been much research done outside of Russia. But early studies have shed light on a number of possible causes, such as:

Increases BDNF Levels in the Brain:[R] [R][R

Brain-derived neurotrophic factor (BDNF) is a protein produced by the central nervous system that supports the growth, survival, and development of neurons. BDNF is also crucial for synaptic plasticity, which is the basis of memory and learning processes. Animal studies have suggested that Semax might enhance the synthesis of BDNF. For instance, research conducted on rats demonstrated that nasal administration of Semax increased BDNF levels in the rat hippocampus and basal forebrain. Another study revealed that Semax therapy resulted in an eight-fold increase in BDNF levels.

It is important to note that further research is necessary to fully elucidate the precise mechanisms of action of Semax. The existing studies provide valuable insights into its potential effects on BDNF levels and enkephalin breakdown, but more comprehensive research is needed to establish a comprehensive understanding of Semax’s workings.


The scientific basis behind the benefits of Semax

Numerous research investigations and trials on animals suggest that Semax may have a number of benefits. 


Dopamine Release

Animal research has indicated that Semax has the potential to activate dopaminergic brain circuits in rodents. This effect was observed with the involvement of D-Amphetamine as a mediator. Furthermore, the increase in dopamine levels resulting from Semax administration was found to be more than 20-fold compared to the basal values.[R]

To fully comprehend the mechanisms and effects of Semax-induced dopamine activation in humans, more research is needed, as the above studies were performed on animal models.



Semax holds promising potential as a therapeutic option for attention-deficit hyperactivity disorder (ADHD), as suggested by a 2007 study. The study highlights the potential benefits of Semax on adult learning and memory development. Animal studies also showed that Semax affected brain growth and BDNF (brain-derived neurotrophic factor) release, hence the findings of this study are significant.  Moreover, animal studies have revealed that combining Semax with one of the regularly used drugs for ADHD therapy can increase the medication’s effect on dopamine levels. These results suggest that the therapeutic advantages of psychostimulants for treating ADHD could be increased by the addition of Semax. [R]

It is important to note that further research is needed to fully explore and validate the efficacy and safety of Semax as a treatment for ADHD. 



A 1997 Russian study suggests that Semax may have a significant impact on memory and concentration, particularly in healthy men experiencing stressful conditions. According to the study, Semax has the potential to enhance operative memory and attention in both humans and experimental animals.[R]

Another study conducted on rats showcased Semax’s ability to reverse the suppression of learning and memory caused by heavy metal exposure. In this research, Semax demonstrated comparable or even significantly greater efficacy in counteracting the inhibitory effects when compared to ascorbic acid (vitamin C). These findings indicate that Semax may possess antioxidant pharmacological properties, further adding to its potential cognitive benefits.[R]

It is important to note that while these studies provide promising insights into the potential of Semax to enhance memory and counteract memory impairment, further research is required to fully comprehend and validate the effects of this peptide on memory. 


Brain Health

Research conducted on rat brain focal ischemia suggests that Semax’s neuroprotective benefits may stem from its ability to influence the expression of genes related to the immune and vascular systems. This indicates that Semax has the potential to protect the brain from damage and support its overall health.

In a clinical trial involving 100 test subjects who had ischemic stroke, Semax was administered alongside intensive conventional therapy. The results demonstrated that Semax accelerated the recovery of impaired brain functions, particularly in relation to motor problems. Notably, these positive effects were observed within a short treatment period of either 5 or 10 days.[R]

Another study explored the potential of Semax to reduce overall brain damage in individuals with compromised blood flow to the brain. The research suggested that Semax might also decrease the future risk of stroke. Importantly, the trial found that Semax was well tolerated by the participants, further highlighting its potential as a safe and beneficial intervention.[R]

While these results show promise for Semax’s effect on brain health, it is essential to emphasize that additional study is required to confirm these findings.


Heart Health

An animal study investigated the impact of Semax on heart rates in rats following myocardial infarction (MI), commonly known as a heart attack. The results showed that Semax was able to inhibit hypertrophy, which refers to excessive cardiac growth triggered by hypertension. [R

Another rat investigation confirmed that Semax reduces the sympathetic nervous system hyperactivity brought on by MI. During the post-infarction (post-heart attack) period, sympathetic nervous system stimulation may encourage heart failure if left unchecked. [R]

It is important to note that these findings were obtained from animal studies, and further research is needed to determine the precise mechanisms and implications of Peptide Semax’s effects on heart health in humans.


Cognitive Functions

Studies conducted on rats have provided insights into the potential effects of Semax on cognitive brain function. One study observed that Semax treatment significantly increased the number of conditioned avoidance responses in rats. This finding led researchers to hypothesize that Semax may have a positive impact on cognitive functions. Conditioned avoidance responses are behavioral indicators of cognitive abilities, suggesting that Semax may enhance cognitive processes in the brain. In another trial, Semax was investigated for its potential to alleviate cognitive impairment induced by acute stress. The study suggested that Semax administration may have mitigated the negative effects of acute stress on cognitive function. This indicates that Semax might possess protective properties against stress-related cognitive decline.[R][R]


Depression and Stress

Semax has shown potential as a therapeutic treatment for depression based on research conducted on rats. A single dose of Semax led to an increase in BDNF levels in the rat hippocampus, along with stimulation of the tyrosine kinase B receptor (TrkB). These findings are noteworthy because TrkB signaling activation is associated with the behavioral effects typically observed with antidepressants, and decreased BDNF has been linked to the pathophysiology of depression. [R]

Studies on animals suggest that Semax may help mitigate the negative consequences of stress. Semax has demonstrated the ability to reduce the stress-related increase in macrophages, which are white blood cells that can become hyperresponsive after exposure to toxins. Additionally, research conducted on rats has shown that Semax treatment can alleviate cognitive damage caused by acute constrained stress. Furthermore, persistent Semax treatment has been found to have an anxiety-reducing effect in healthy individuals. [R][R][R]

While these findings show promise, further research, including clinical studies involving human participants, is necessary to fully understand the mechanisms and potential therapeutic applications of Semax peptide in relation to depression and stress-related conditions.



The information presented here is for educational purposes only and should not be construed as medical advice. Semax is intended for laboratory research use only and is not intended for human consumption.


Potential side effects

Because there hasn’t been any clinical study done on this medication, there is currently no solid information about any potential side effects.


Where can I Buy Semax? offers  Semax research chemicals strictly for laboratory research use only.

When buying good stuff such as Semax, it is important to choose a reputable seller who provides quality products. At, each product is accompanied by a third-party-issued Certificate of Analysis showing the identification, purity, and concentration of our product. 



Semax is a synthetic neuropeptide developed to treat circulatory disorders and acute cerebral hypoxia. 

It has been shown to increase dopamine levels in the brain, enhance memory and mental clarity, and potentially possess neuroprotective properties. Semax has been researched for its potential benefits in conditions such as ADHD, dopamine activation, memory enhancement, brain health, heart health, stress reduction, depression, and cognitive function.
However, it’s important to note that Semax has not been cleared by the FDA and has not undergone comprehensive clinical studies. Therefore, there is limited information on its potential side effects. 



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