Sermorelin, also known as GHRH-(1-29), is a prototypical growth hormone secretagogue (GHS) and an analog derived from the first 29 amino acids of the growth hormone-releasing hormone (GHRH) protein. It operates on the hypothalamic-pituitary-somatotropic axis leading to hypothalamic and pituitary hormones, distinct from other GHS that function through the ghrelin/GHS-R pathway. The activation of the GHRH receptor by Sermorelin leads to the production of cAMP via the Gs protein/adenylate cyclase and mitogen-activated protein kinase pathways.[R]
Research indicates that Sermorelin has been used for both the diagnosis and treatment of growth hormone (GH) deficiency, with limited exploration in the context of hypogonadism. While it appears to have a favorable safety profile with minimal adverse effects, further large-scale, longitudinal studies are needed to fully understand and characterize the complementary role of Sermorelin in the management of conditions like hypogonadism and growth hormone deficiency.[R]
This product was made by RCD.Bio is not for human consumption, but as a useful tool for researchers who want to learn more about how these compounds work on growth hormone, bone growth, muscle growth and research for clinical studies.
RCD.Bio offers Sermorelin Nasal Sprays with the following specifications: [R]
- A purity of 98%, verified by third-party laboratory testing.
- Available in nasal spray form: 100mcg per spray/10mg/10ml
- CAS No: 86168-78-7
- Chemical Formula: C149H246N44O42S
- Molar Mass: 3357.9 g/mol
- IUPAC Name: DL-tyrosyl-DL-alanyl-DL-alpha-aspartyl-DL-alanyl-DL-isoleucyl-DL-phenylalanyl-DL-threonyl-DL-asparagyl-DL-seryl-DL-tyrosyl-DL-arginyl-DL-lysyl-DL-valyl-DL-leucyl-glycyl-DL-glutaminyl-DL-leucyl-DL-seryl-DL-alanyl-DL-arginyl-DL-lysyl-DL-leucyl-DL-leucyl-DL-glutaminyl-DL-alpha-aspartyl-DL-isoleucyl-DL-methionyl-DL-seryl-DL-argininamide
How does Sermorelin Nasal Spray Work?
Sermorelin Nasal Spray might be better for test subjects than other ways of giving Sermorelin because it is more convenient, easier to use, might work faster, and causes less discomfort unlike sermorelin injections. But the safety and effectiveness should be carefully checked out in well-planned research studies or clinical trials particularly in the nasal spray form.
Sermorelin is a synthetic form of the hormone that releases growth hormone (GHRH). A study shows that GHRH activates mitogen-activated protein (MAP) kinase through pathways involving adenylyl cyclase, cAMP, and protein kinase A. Cellular signaling is shown by this one-of-a-kind pathway that is different from the usual cAMP-dependent mechanism. By understanding these processes, we can get a sense of how Sermorelin might help the body. By changing how many somatotroph cells multiply, Sermorelin may help with processes that are necessary for growth and maintenance. The fact that MAP kinase is activated suggests that it plays a part in how cells respond. Even though the study doesn’t directly look at how Sermorelin can be used by humans, the complex mechanisms that were found show how useful it could be in research settings and help us learn more about how it affects the functions of cells in the body.[R]
The scientific basis behind the benefits of Sermorelin Nasal Spray
Numerous research investigations and trials on animals suggest that Sermorelin Nasal Spray use may have a number of benefits, including:
Body Composition Changes With Age
The study explores the impact of Growth Hormone-Releasing Hormone (GHRH) injections, specifically the synthetic form Sermorelin, on aging-related changes in growth hormone (GH) and insulin-like growth factor-I (IGF-I) levels in men. Aging is associated with declines in GH and IGF-I, contributing to changes in body composition such as decreased lean body mass and increased body fat.The research involves healthy young and old men, with baseline measurements revealing lower spontaneous GH release and IGF-I levels in the older group. Upon administering GHRH injections, there were dose-related increases in GH and IGF-I levels, with significant improvements observed at the higher dose. Importantly, after high-dose treatment, no significant differences in these parameters were found between age groups. The study suggests that short-term Sermorelin administration to healthy older men can effectively reverse age-related declines in GH and IGF-I levels, indicating a potential avenue for addressing age-related alterations in body composition.[R]
Increased Muscle Mass and Improved Body Composition
The investigation underscores that the nightly administration of the GHRH analog [Nle27]GHRH-(1–29)-NH2, or Sermorelin, for four months yielded noteworthy gains in lean body mass, particularly evident in men. The anabolic effects initiated by the GHRH analog contributed to a discernible increase in lean body mass, suggesting a potential counteraction to age-related declines in muscle mass. This discovery implies that Sermorelin may confer a positive influence on body composition, fostering the preservation or augmentation of lean muscle mass, specifically among the male test subjects in the study. [R]
Another study addresses age-related declines contributing to reduced muscle mass and strength in older individuals. Administering Sermorelin, a growth hormone-releasing hormone(GHRH), over six weeks resulted in increased nocturnal GH release and improvements in muscle strength and endurance. GHRH treatment demonstrated potential benefits, such as enhanced muscle function without significant adverse effects. While the study did not show major changes in body composition or metabolic factors, the observed positive impact on muscle strength suggests that Sermorelin may be valuable in addressing age-related issues related to muscle health. [R]
To address age related declines this, pharmacological approaches like growth hormone therapy (sermorelin therapy) have been explored. Another study has showed that Sermorelin, an FDA-approved treat gh deficiency for pediatric patient, is well-tolerated by aging test subjects. It increases 24-hour Growth hormone secretion, raises insulin-like growth factor-I levels, and improves body composition. t Sermorelin may offer benefits in countering age-related declines in muscle and overall physical function. [R]
Enhanced Insulin Sensitivity
In a similar study, GHRH analog treatment increased insulin sensitivity in male test subjects within four weeks. This improvement in insulin sensitivity helps address age-related metabolic function changes. The findings suggest that Sermorelin may improve glucose regulation and metabolic health in aging adults.[R]
Another noteworthy effect observed in male test subjects undergoing GHRH analog treatment was a substantial improvement in libido. This observation implies a plausible connection between Sermorelin administration and the amplification of sexual health-related parameters. While the study notes that this enhancement was specific to male test subjects , it highlights a potential avenue for further exploration into the impact of GHRH analogs on facets of reproductive health and well-being, offering valuable insights into the broader implications of Sermorelin administration..[R]
Enhance Endogenous GH Levels
The study investigates the potential of growth hormone-releasing peptides (GHRPs) and the GH-releasing hormone analog, sermorelin (SERM), as a safe alternative to human growth hormone (GH) for enhancing endogenous GH levels. The focus is on insulin-like growth factor 1 (IGF-1) as a surrogate marker for GH activity. In a retrospective review involving 105 male test subjects on testosterone therapy seeking improvements in lean body mass and fat loss. The results revealed that strict compliance with thrice-daily dosing of GHRP/SERM therapy significantly increased serum IGF-1 levels. Importantly, the study suggests that inhibition of estrogen production or estrogen receptor blockade may influence the effectiveness of the therapy, emphasizing the intricate interplay between hormonal factors. These findings propose that GHRP/SERM combination therapy could be beneficial, particularly for test subjects with wasting conditions that may improve with increased GH secretion. Overall, the study contributes valuable insights into the potential of Sermorelin in promoting endogenous GH activity and its implications for enhancing body composition.[R]
Mild Cognitive Impairment
The study explores the effects of growth hormone-releasing hormone (GHRH) on brain γ-aminobutyric acid (GABA) levels in individuals with mild cognitive impairment (MCI) and healthy aging. The aged test subjects underwent a 20-week randomized, double-blind, placebo-controlled substudy. Administered daily subcutaneous injections of tesamorelin, a stabilized analogue of human GHRH. After 20 weeks of GHRH administration, the study found increased GABA levels in all three brain regions, elevated N-acetylaspartylglutamate (NAAG) levels in the frontal cortex, and decreased myo-inositol (MI) levels in the posterior cingulate. These neurochemical changes were consistent in both test subjects with MCI and those with normal cognitive function. The results suggest that GHRH administration may modulate inhibitory neurotransmitter and brain metabolite levels, providing preliminary support for a potential mechanism explaining the favorable effects of GHRH on central nervous system cognition in test subjects with MCI.[R]
Is Sermorelin Nasal Spray legal?
As of the provided information, Sermorelin, including Sermorelin Nasal Spray, was withdrawn from the United States market by the manufacturer in November 2002. [R] This means that there are no U.S. Food and Drug Administration (FDA)-approved Sermorelin products available for routine use. While Sermorelin itself is licensed as a diagnostic test for the secretion of growth hormone and is used for the treatment of growth hormone deficiency in children, the specific Sermorelin products were taken off the market. [R]
Where Can I Buy Sermorelin Nasal Spray online?
When buying Sermorelin Nasal Spray , it is important to choose a reputable seller who provides quality products. At RCD.bio, each product is accompanied with a third-party-issued Certificate of Analysis showing the identification, purity, and concentration of our product.
To sum up, Sermorelin, also known as GHRH-(1-29), works on the pituitary gland and has unique pathways that make it different from other growth hormone secretagogues. Even though Sermorelin was taken off the U.S. market in 2002, it is still useful for researchers who want to learn more about how it affects bone marrow stem cells, nuclear gene expression, cellular energy balance, and different diseases. Sermorelin Nasal Spray, whose details were provided by RCD.Bio, is easy to get and might work for test subjects. However, it needs to be carefully studied in well-planned clinical trials or research studies to make sure it is safe and effective.
There is good scientific evidence that Sermorelin may have benefits, such as the ability to help with changes that happen with age in body composition, muscle mass, insulin sensitivity, libido, and brain function. Studies have shown that the results are good, with more lean body mass, stronger muscles, and better insulin sensitivity. Even though Sermorelin Nasal Spray has been taken off the market, its legality is still up in the air. However, the compound’s complex mechanisms and positive effects seen in research studies show that it could help us learn more about how cells work and be used to treat a wide range of health problems.
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