Sunifiram is an innovative substance that works to potentially improve memory, attention, and general cognitive performance. Learn about its origins, advantages, and how it could enable research on how to fully utilize brain function.

Before digging into the product’s general overview and data, remember that Sunifiram and other research compounds are only meant for scientific investigation and are not recommended for human consumption.

What is Sunifiram Powder

Sunifiram powder is an experimental research chemical derived from Piracetam. It is well-known for its potent anti-amnesia effects. While it is frequently associated with racetam compounds, it is technically not a racetam due to its broken pyrrolidone backbone. However, in terms of cognitive-enhancing qualities, it is like racetams. Research has shown that it has significantly greater potential potency than Piracetam or Phenylpiracetam. (R)

It was originally developed to treat the symptoms of cognitive decline in Alzheimer’s disease patients. However, due to the lack of funding, no human trials were conducted to review its effects. All the evidence about its effects comes from animal studies. (R) (R)

Nootropics, or “smart drugs,” are compounds that can potentially improve cognitive function, such as memory, attention, creativity, and motivation as they may have a potentially potent anti-amnesia effect. Sunifiram is a novel molecule that belongs to this class. It is particularly renowned for its capacity to improve memory recall and learning. Sunifiram is related to Unifiram – it is a chemically simplified version of Unifram. (R) (R)

In the 2000s, a group of researchers looking for novel molecules that can enhance cognitive capacities created Sunifiram (molecular weight: 246.304 g/mol) for the first time. It attracted attention due to its potential special qualities and capacity to activate certain brain receptors linked to memory and learning. Studies indicate that one key mode of action for Sunifiram is through potential interactions with the glutamergic system – particularly through AMPA-receptor activation. (R)

Even though Sunifiram is a relatively new substance, interest in its potential cognitive improvement has been constantly rising. It is sometimes offered as a dietary supplement even though it is neither controlled by the government nor licensed for use in medicine. Results from a mice study suggest that Sunifiram activates the AMPA-mediated neurotransmission system. Plus, it may block AMPA receptor activation by drugs that suppress the activity of AMPA receptors. (R)

Potential Benefits of Sunifiram

Sunifiram DM-235 and Improved Memory:

Sunifiram may help improve short-term and long-term memory, helping you recall and retrieve information more quickly. In research trials, it improved focus, alleviated cognitive deficits, and possessed potent anti-amnesia effects. It is considered an ampakine-like nootropic effect, meaning it shares similarities with ampakine compounds in terms of its cognitive-enhancing effects. (R) (R)

Sunifiram DM-235 and Enhanced Focus and Concentration:

Sunifiram research may allow you to focus on work for extended periods without interruptions by generating heightened alertness, and concentration and enhancing the attention span. Research suggests that it may have an impact on long-term potentiation. By modulating certain neurotransmitters and receptors in the brain, Sunifiram has been shown to potentially enhance synaptic plasticity. (R)

Sunifiram DM-235 and Increased Mental Clarity:

Research shows Sunifiram may aid in the removal of brain fog and enhance mental clarity, making it simpler to think critically and solve issues. (R)

Sunifiram DM-235 and Potential Mood Enhancement:

Some subjects have reported feeling happier and more motivated in studies utilizing Sunifiram. (R)

Sunifiram DM-235 and Neuroprotective Properties:

Sunifiram has been examined for its ability to protect brain cells against oxidative stress and age-related cognitive impairment. (R)

Key Features

  • Name of Product: Sunifiram Powder
  • Product Type: Powder
  • Purity: 98%
  • Amount of Powder: 5g
  • Appearance: White or off-white powder Physical State
  • Solid Solubility: Freely Soluble in Propylene Glycol
  • Application: Experimental drug with anti-amnesic effects in animal studies
  • Storage: Minimize open-air exposure, store in a cool dry place. Keep away from direct sunlight and heat.
  • Variants: Available in Powder (5000mg) only.
  1. CAS Number: 314728-85-3
  2. Molecular Weight: 246.304 g/mol
  3. Chemical Formula: C14H18N2O2S
  4. IUPAC Name: N-(2,3-Dimethyl-5,6,7,8-tetrahydrofuro[2,3-b]quinolin-4-yl)-2-(2-oxopyrrolidin-1-yl)acetamide
  5. Also known by Synonyms: DM-235, DM-232 (R)

How Does Sunifiram Work?

Sunifiram as a freely soluble powder works in the brain by regulating specific neurotransmitters and receptors, with one key mode of action notably those involved in memory formation. It is thought to increase synaptic plasticity, which is important for building neural connections and enhancing information storage. (R)

Although its exact working mechanism remains unknown, Sunifiram has been shown to: Stimulate the release of acetylcholine. In one animal study, Sunifiram reportedly increased acetylcholine release. Another preclinical study showed it blocked the effects of scopolamine, a drug that blocks acetylcholine release. (R)

Sunifiram powder may also boost the release of acetylcholine, a neurotransmitter associated with memory. Sunifiram may increase the capacity to acquire, process, and retain information by increasing cholinergic activity. The animal study has shown that it has significantly greater potency than Piracetam or Phenylpiracetam. Sunifiram is related to Unifiram – it is a chemically simplified version of Unifram. (R)

Sunifiram is an experimental research chemical derived from Piperazine. has been shown in trials of animal studies to have significantly greater potency than other well-known racetam compounds such as Piracetam or Phenylpiracetam. Because of its potential to boost memory and cognition, it has been the topic of scientific studies. (R)

Sunifiram a freely Soluble in Propylene Glycol exerts its effects by influencing certain cellular signaling pathways in the brain. It has been found to potentially increase the phosphorylation of a protein called PKCα, which plays a role in cell signaling. 

The mechanism of action of Sunifiram is dependent on the availability of the glycine binding site. Interestingly, Sunifiram acts as a potential antagonist to glycine at a concentration of 300μM (micromolar). This means that it interferes with the binding of glycine to its receptors. (R)

Additionally, Sunifiram has been associated with increased activity of AMPA receptor activation, which is part of synaptic transmission and plays a crucial role in learning and memory. (R)

Sunifiram (DM-235) is a highly potent AMPAkine-like nootropic up to three orders with anti-amnesic and cognition-enhancing effects in animal studies at up to three orders of magnitude higher potency than piracetam. (R) This increased activity of AMPA receptors is linked to the phosphorylation of two other proteins, CAMKII and PKCα. These proteins are important for potential cellular signaling processes. Studies indicate that one key mode of action for Sunifiram is through interactions with the glutamergic system – particularly through AMPA and NMDA receptor activation. (R) (R)


While Sunifiram, a freely soluble powder has an active ingredient, it may have potential benefits for research purposes. Always remember that this powder and other research compounds are only meant for laboratory research. We do not recommend it as a dietary supplement, or use it on subjects with suspected medical conditions or who are taking prescription drugs. The compound is not to diagnose, treat, or cure any disease or should not be used as a substitute for a varied diet.

At, we sell this powder solely for research use and do not suggest or endorse its use for anything else. If you are using this product for investigation, please follow all safety instructions and handling precautions.

Sunifiram powder has not been approved by the World Anti-Doping Agency (WADA) or the U.S. Food and Drug Administration (FDA). No human studies have been conducted to investigate the effects and/or toxicological profile of Sunifiram. It is important to note that regulations and approvals may change over time, so it’s recommended to check the latest updates from these organizations when you buy Sunifiram powder. (R) (R)

Potential Side effects

  • Headaches: Some subjects have reported experiencing headaches as a side effect of Sunifiram studies. This could be due to the compound’s effects on neurotransmitters and brain activity. (R)
  • Overstimulation: Sunifiram has the potential to increase brain activity and stimulate certain receptors. In some cases, this increased stimulation may lead to feelings of restlessness, nervousness, or anxiety in subjects. (R)
  • Sleep disturbances: Due to its stimulating properties, Sunifiram may interfere with sleep patterns in some subjects. (R)
  • Lack of long-term safety data: As a compound, Sunifiram does not have an extensive history of long-term use or comprehensive safety data. Therefore, potential risks and side effects may not be fully known. (R)
  • Individual variations: Each subject’s response to Sunifiram may vary. Some subjects may experience no side effects or only mild ones, while others may be more sensitive and experience more pronounced effects. (R)


Finally, Sunifiram is a chemical that is currently considered experimental and is classified as a cognition-enhancing compound. It is well known for its potential to boost general cognition, as well as memory and concentration. Despite being connected to racetam compounds on occasion, its unique chemical makeup completely disqualifies it from being a racetam.

Sunifiram acts in the brain by altering neurotransmitters and receptors, boosting synaptic plasticity, and maybe improving long-term potentiation. It has been linked to the phosphorylation of proteins such as CAMKII and PKC, which are implicated in cellular signaling related to memory, as well as enhanced AMPA receptor activation.

Further study may offer information on the exact processes of Sunifiram, its appropriate dosage, any adverse effects, and its overall usefulness as a cognitive-enhancing compound in the future. Continued study efforts may increase our understanding of Sunifiram’s involvement in cognitive function enhancement and may contribute to the creation of new and safer nootropic substances. (R)


Please take note of the scientific applications of this product and carefully read our Terms and Conditions when you buy Sunifiram at You agree to abide by our Terms and Conditions by completing your order and submitting payment. Please be aware that the product packaging may differ slightly from the images displayed on our website.

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PLEASE NOTE: All products offered by are strictly intended for laboratory and research purposes only. They are not for use on animals or humans.