Bitter orange extract, sourcad from the Citrus aurantium tree, harbors a naturally occurring substance called synephrine alkaloids. This active component is renowned for its potential to facilitate fat-burning and support weight loss efforts. It’s worth noting that synephrine bears similarities to ephedrine, a substance that caused cardiac concerns, leading to its prohibition by the FDA in 2004.

Following this ban, the weight loss and bodybuilding industries turned their attention to bitter orange extract, often in conjunction with caffeine, as a substitute. Bitter orange contains a variety of compounds capable of influencing the nervous system, potentially impacting factors associated with shedding pounds. Nevertheless, it is imperative to exercise caution when considering products containing bitter orange extract, as these constituents may carry heart-related risks, particularly for healthy adults.

Please note that the information provided here serves solely for informational purposes and does not constitute an endorsement or recommendation of any specific dietary supplement or product. It is advisable to consult with a healthcare professional prior to using any weight loss or dietary supplements, particularly if you have underlying health conditions or are taking other medications.

Product Details

Synephrine, also known as synephrine HCl, can be discovered in Bitter Orange Extract sourced from the Citrus aurantium plant. It is a naturally occurring compound recognized for its potential in promoting fat burning and controlling appetite. Bitter orange, originally hailing from Southeast Asia but now cultivated worldwide, contains a diverse array of beneficial components, including vitamins C and K.

Within bitter orange extract, synephrine HCl exhibits inherent stimulating properties and a thermogenic effect. This unique combination of characteristics contributes to its remarkable advantages. It possesses the capacity to boost the body’s metabolism, facilitating the breakdown of surplus fat, and has been linked to appetite suppression, particularly in curbing cravings for sugary foods, making it valuable for individuals looking to manage their dietary habits. Additionally, it may lend support to various metabolic processes in the body, potentially enhancing overall metabolic well-being and optimizing urinary system function.

Key Features

  • 98% Product Purity
  • Sold for research purposes only

Potential Benefits of Synephrine HCl

Metabolic Rate & Fat Burning

In a study involving 10 participants who were administered 50 mg of p-synephrine, it was observed that within the initial 75 minutes post-supplement intake, these test subjects burned an additional 65 calories compared to those who received a placebo. [R]

The group receiving synephrine did not exhibit any elevation in blood pressure or heart rate, highlighting its safety profile.

Another study conducted with 17 participants, who were given p-synephrine before exercise, revealed a preference for fat over carbohydrates as the energy source during physical activity. Notably, no discernible impact on heart rate was recorded. [R]

A separate investigation involving 23 participants who consumed a combination of caffeine and bitter orange extract (C. aurantium) showcased an increased fat-burning effect, even during periods of rest, compared to the placebo group. This study also revealed no disparities in heart rate or blood pressure between the two sets of participants. [R]

These findings find support in a study featuring 12 males, which demonstrated heightened fat burning during rest and up to 30 minutes post-exercise in test subjects given synephrine, either alone or in combination with caffeine, as opposed to those on a placebo. However, in this study, only the caffeine group exhibited elevated heart rates. [R]

For synephrine to stimulate fat burning during rest, minor doses of caffeine might be necessary. A study involving 18 participants found that p-synephrine alone, without caffeine, did not lead to increased resting fat oxidation but did enhance fat burning during exercise. [R]

Irritable Bowel Syndrome

Synephrine demonstrated the ability to reduce the motility of intestinal muscles in animal studies. As overactive intestinal muscles are linked to various stomach issues, including irritable bowel syndrome and constipation, while there are no direct studies associating synephrine with symptom relief, its potential to reduce intestinal muscle movement offers promise for future research in addressing these gastrointestinal conditions. [R]

Athletic Performance

In a study involving 12 male test subjects, taking p-synephrine 45 minutes before exercise resulted in an increase in the number of repetitions and maximum weight load during squats compared to a placebo. The addition of caffeine to p-synephrine further amplified these subjects’ maximal squat repetitions and weight load. [R]

Conversely, another study featuring 13 athletes who were given p-synephrine did not demonstrate any significant improvement in sprint velocity or jumping heights compared to those receiving a placebo. [R]

Antifungal Activity

Bitter orange oil, which includes synephrine among other active compounds, exhibited promising antifungal properties in a study involving 60 test subjects. Over the course of 2 to 3 weeks, over 80% of participants saw improvements in fungal skin infections affecting areas like the feet, body/skin, or groin. [R]

Allergy Symptoms

A study involving guinea pigs revealed that synephrine reduced tracheal smooth muscle spasms, a symptom associated with coughing. Additionally, synephrine alleviated asthma symptoms induced by histamines in these animals. [R]

Mood and Energy Levels

Mice exhibiting classic signs of depression, including sleep disturbances and altered eating habits, showed improved responses to stress-inducing activities, such as forced swimming, when fed synephrine. This indicates heightened levels of energy and mood in the presence of synephrine. [R]

Antimicrobial Activity

Laboratory research demonstrated that synephrine had antimicrobial properties, inhibiting the growth of bacteria including E. coli, responsible for food poisoning, and Staphylococcus aureus, known for causing skin infections. [R]


In mice models with lung injuries, synephrine displayed anti-inflammatory properties by reducing the number of inflammatory cells and levels of inflammatory cytokines TNF-alpha and IL-6, while increasing the presence of the anti-inflammatory IL-10. [R]

Additionally, synephrine inhibited the activation of NF-κB, a factor often overactive in numerous inflammatory diseases such as asthma, inflammatory bowel disease, and psoriasis. [R]

In cell studies, synephrine halted the production of eotaxin-1, a molecule that signals eosinophils to migrate to inflamed areas, and blocked the activity of NADPH oxidase, an enzyme produced by neutrophils that generates reactive oxygen species. [R]

How It Works

The active substances found in citrus aurantium, commonly referred to as bitter oranges, are believed to function as sympathetic adrenergic agonists, triggering receptors associated with the “fight or flight” reaction. This mechanism prompts heightened cardiovascular activity, leading to an elevated heart rate and blood pressure. Furthermore, these active substances have the potential to rev up metabolism, augment resting metabolic rate, and facilitate the breakdown of fat, a process known as lipolysis. Additionally, they may contribute to appetite control by slowing down the movement of food through the gastrointestinal tract.


When researching the use of Synephrine, it is essential to take certain precautions. Here are some precautions to keep in mind:

Observe best practices for studying research chemicals

Studying research chemicals requires a responsible and informed approach to ensure safety and meaningful medical sciences exploration. Research chemicals, also known as designer drugs or experimental compounds, are substances synthesized for scientific investigation or exploration of their properties.

Potential Side Effects

Dietary supplements containing synephrine have been associated with serious side effects. To prevent adverse reactions or unexpected interactions, it is crucial to consult with a healthcare professional before considering synephrine supplementation. Reported side effects encompass hallucinations and psychosis, coronary spasms and thrombosis, disruptions in heart rhythm (ventricular fibrillation), a reduction in muscle size (rhabdomyolysis), kidney failure, blood clots, nerve damage arising from increased muscle pressure (bilateral compartment syndrome), chest pain (variant angina), and even the risk of stroke. Therefore, cautious consultation with a medical expert is paramount when contemplating the use of synephrine-based supplements.


In conclusion, the utilization of synephrine, often found in dietary supplements in the form of synephrine HCl, has garnered attention within the realm of obesity treatment and nutrition. As highlighted by a review in Obesity Reviews, synephrine presents a link to potential benefits, including increased energy, making it a subject of interest in the quest to combat obesity and overweight issues. However, it is vital to approach its use with caution and meticulous consideration. The claims of its efficacy should not exceed the scientific evidence available, and suitable dosages must be determined in consultation with a healthcare professional.

Quality matters, not only in terms of the synephrine supplier but also in the overall quality of the dietary supplement. The focus should remain on transparent and reliable information regarding its usage, keeping in mind that synephrine should not replace prescribed medications or serve as the sole treatment for obesity. As we navigate this promising yet potent avenue in the field of nutrition, maintaining a balanced approach that prioritizes safety, efficacy, and the highest standards of quality remains paramount.


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