Introduction

TB-500, a synthetic peptide or protein, has garnered significant attention owing to its promising capabilities in the repair of injured or damaged tissues and the facilitation of regeneration. Its potential applications extend to enhancing the overall healing process in cell and tissue repair, demonstrating anti-inflammatory properties, promoting eye health, mitigating lung tissue damage, and addressing mutagenic effects. [R]

Despite its clinical utilization and the evidence of positive effects, the comprehensive scope of TB-500’s actions remains inadequately understood. The intricate mechanisms behind its varied benefits continue to be a subject of ongoing research.

RCD.Bio developed this product not for human use but as a valuable tool for researchers seeking to delve into the effects of these compounds. By providing a platform for scientific exploration, RCD.Bio aims to contribute to the expansion of knowledge surrounding TB-500 and its potential applications. Researchers can leverage this synthetic peptide to uncover new insights, paving the way for a deeper understanding of its biological mechanisms and therapeutic potential.

Key Features

RCD.Bio offers TB-500 with the following specifications:

  • A purity of 98%, verified by third-party laboratory testing.
  • Available in nasal spray form: 100mcg per spray/10mg/10ml
  • CAS No:  16132341
  • Chemical Formula: C212H350N56O78S
  • Molar Mass: 4963 g/mol
  • IUPAC Condensed: Ac-Ser-Asp-Lys-Pro-Asp-Met-Ala-Glu-Ile-Glu-Lys-Phe-Asp-Lys-Ser-Lys-Leu-Lys-Lys-Thr-Glu-Thr-Gln-Glu-Lys-Asn-Pro-Leu-Pro-Ser-Lys-Glu-Thr-Ile-Glu-Gln-Glu-Lys-Gln-Ala-Gly-Glu-Ser-OH

What is TB-500?

TB-500, a synthetic peptide, is currently under investigation for its remarkable potential in fostering healing processes and promoting tissue regeneration.[R] Originally derived from Thymosin Beta-4, a peptide found in human tissues that occurs spontaneously. This protein is encoded by TMSB4X gene in humans. [R]

The protein consists (in humans) of 43 amino acids (sequence: SDKPDMAEI EKFDKSKLKK TETQEKNPLP SKETIEQEKQ AGES). [R]

How does TB-500 Work?

Thymosin Beta-4 (Tβ-4), also known as TB-500, is a synthetic peptide that is believed to function by enhancing cellular processes associated with tissue regeneration and repair. The peptide LKKTETQ, which has its N-terminus artificially acetylated, is the main component of TB-500. It is stated that TB-500 increases the development of endothelial cells, angiogenesis in dermal tissues, keratinocyte cell migration, the deposition of collagen, and reduces inflammation. [R]

TB-500 may function in the following ways, while the precise mechanisms of action are still unclear:

It is thought that TB-500 promotes the migration and differentiation of new blood cells. This suggests that it might promote the migration of cells to the site of damage and their differentiation into the particular cell types required for tissue repair. This may be especially important for the repair of ligaments, tendons, and muscles. [R]

Angiogenesis, the development of new blood vessels or blood vessel growth, is a process that TB-500 may help to promote. By promoting angiogenesis it increases blood flow to injured tissues and can help the body in injury healing by delivering nutrients, oxygen, and immune cells more easily. Reducing inflammation in damaged or injured tissues may help create an environment that is more conducive to the rehabilitation and recovery process. [R] Further research is still needed to understand its effect on the immune system and plasma cells,

The scientific basis behind the benefits of  TB-500

Numerous research investigations and trials on animals suggest that  TB-500 may have several benefits. 

Tissue Repair and Regeneration

In research experiments, the potential efficacy of TB-500 has been substantiated through various actions critical to the formation, repair, and preservation of granulation tissue. TB-500 has demonstrated effectiveness in burns and accelerated cutaneous healing rates in diverse preclinical animal models, including those involving diabetic and elderly animal cells. Phase 2 trials, encompassing subjects with pressure ulcers, stasis ulcers, and epidermolysis bullosa wounds, further revealed TB-500’s ability to expedite the healing process. It is important to note that these findings are exclusively for research purposes. [R]

In other conditions for the problem of chronic nonhealing cutaneous wounds, the peptide promoted dermal restoration through a variety of biological actions that are secreted by platelets at injury sites. Tβ4 promotes faster skin healing in full-thickness punch wounds in a variety of animal models, such as elderly and diabetic mice, steroid-treated rats, and normal rats and mice. Tβ4 was also shown to speed up healing in two phase 2 clinical trials on pressure ulcers and stasis, cutting the healing period in test subjects who did see healing by nearly a month. [R]

In another study, to elucidate the pathophysiological role of TB-500 in hypertension, the study utilized 2 types of lab rats. These mice were infused continuously with either vehicle or angiotensin-II (Ang-II) over six weeks. Ang-II is known to play a role in hypertension. They conclude that the substance plays a crucial role in preventing tissue injury associated with Ang-II-induced hypertension. This suggests a protective role for endogenous Tβ-4 in hypertensive end-organ damage, providing new insights into its potential therapeutic significance in hypertension-related conditions. [R]

Furthermore, another study using animal subjects, a rat full-thickness wound model, examined whether the peptide improved wound healing. Tbeta4 administration enhanced reepithelialization by 42% compared to saline controls either topically or intraperitoneally. In the treated wounds, there was an increase in angiogenesis and collagen deposition. In an assay, the study also discovered that the cell-building protein enhanced keratinocyte migration. These findings imply that the peptide is a multifunctional, highly effective wound healing factor that could find application in clinical settings. [R]

Muscle Diseases

A study investigated the effects of continuously giving Thymosin beta-4 (Tβ4) to mdx mice, a mouse model of Duchenne muscular dystrophy (DMD), a genetic disorder causing muscle degeneration and weakness. The findings suggest that Tβ4 may have positive impacts on muscle regeneration, particularly in skeletal muscles, associated with Duchenne muscular dystrophy. However, the study did not observe enhancements in muscle strength or cardiac function. Additional research may be necessary to fully understand the therapeutic possibilities of Tβ4 in treating DMD and related muscle disorders. [R]

Eye Health

Microbial keratitis is a rapid and sight-threatening corneal infection that can lead to perforation, endophthalmitis, and corneal scarring. Staphylococcus aureus and Pseudomonas aeruginosa are the two most commonly associated bacteria with this type of infection. The study proposes that combining TB-500 with antibiotic treatment could potentially improve the overall efficacy of treating bacterial keratitis by facilitating wound healing. This suggests a potential avenue for developing new therapies for corneal infections.[R

It has also been found in a separate study that the healing of corneal wounds is aided by TB-500. TB-500 may provide treatment options for treating wound healing and corneal inflammatory disorders by increasing re-epithelialization in response to injury and modifying the corneal inflammatory response. [R]

Lung Tissue Damage

TB-500, aside from its primary function has been found to have a protective role on lung tissue damage in scleroderma test subjects. This condition is a chronic autoimmune illness characterized by aberrant connective tissue development. [R] Further research is still needed to fully comprehend its potential for treating damage in other organs, such as brain tissue in the central nervous system and gastric ulcers in the human stomach.

Anti-inflammatory action

A recent study has shown the potential of TB-500 sulfoxide, generated in the presence of glucocorticoids, to act as a signal that inhibits inflammatory responses, offering a new perspective on anti-inflammatory therapy. In vitro, TB-500 sulfoxide inhibits neutrophil chemotaxis, essential for the recruitment of neutrophils to sites of infection, inflammation, or tissue damage. It has notably found that it was a potent inhibitor of carrageenin-induced edema in the mouse paw. [R]

Additionally, the potential role of TB-500 in mitigating the effects of sepsis, focusing on its impact on actin dynamics, anti-inflammatory responses, and oxidative stress suggests further investigation in human clinical trials and emphasizes the potential translational significance of these findings. [R] Further research is needed to know its impact on other inflammatory bowel diseases in the gastrointestinal tract.

Mutagenic Effects

In another study, TB-500 was also presented as a potential tumor suppressor in male breast cancer. [R] Other research has shown it to have a tumor-suppressive role in the development of myeloma in clinical trials. [R][R

Cardioprotection

Thymosin beta 4 (Tβ4) is investigated for its regenerative and cardioprotective properties in preclinical research. A mouse model for myocardial infarction was used in the study. Tβ4 or a vehicle (control) was injected either intraperitoneally or intramyocardally in mice. According to the study, Tβ4 therapy improves heart remodeling and function in a mouse model of myocardial infarction. The mechanisms behind Tβ4-mediated cardioprotection may be elucidated by the up-regulation of chitinase 3-like-1 and CD73 activity. [R]

Furthermore, it has also shown a potential to both activate the adult epicardium and mimic its embryonic function without endangering the embryo raising the possibility that the molecule accomplishes the same in additional organs. [R]

Precautions

The information presented here is for educational purposes only and should not be construed as medical advice. TB-500 is intended for laboratory research use only and is not intended for human consumption.

Frequently Asked Questions

What advantages come from combining TB-500 and BPC-157?

Combining TB-500 and Body Protection Compound (BPC) -157 is believed by some to offer enhanced therapeutic benefits, although healing is naturally occurring, this stack was known to synthetically improve wound healing, reduce inflammation, and more effective tissue repair and regeneration. 

Is  TB-500  legal?

As of now, the Food and Drug Administration (FDA) does not regulate TB-500. The World Anti-Doping Agency (WADA) has also outlawed thymosin beta-4 and its derivatives, including TB-500, making it illegal for competitive athletes to use them by the WADA Code and similar national and regional regulatory authorities. [R]

Where Can I Buy TB-500 Online?

When buying TB-500, it is important to choose a reputable seller who provides quality products. At RCD.bio, each product is accompanied by a third-party-issued Certificate of Analysis showing the identification, purity, and concentration of our product.

Conclusion

TB-500, a synthetic peptide obtained from Thymosin Beta-4, has gained recognition for its potential to facilitate tissue regeneration and healing. Through its ability to augment cellular processes related to tissue repair, TB-500 facilitates angiogenesis, collagen deposition, and inflammation reduction. The multifaceted utility of this substance encompasses a range of health conditions, such as muscle disorders like Duchenne muscular dystrophy, eye health, protection against lung tissue damage, anti-inflammatory activity, and potential cardioprotection.

In numerous preclinical models, research indicates encouraging outcomes regarding the acceleration of wound healing, skin restoration, and tissue repair. Moreover, TB-500 has demonstrated potential advantages in the reduction of inflammatory reactions and may even function as a tumor suppressant. It has been proposed that the concurrent administration of TB-500 and BPC-157 may yield augmented therapeutic advantages, rendering it a potentially significant alternative for individuals in pursuit of holistic tissue regeneration and healing.

Notably, although preliminary investigations indicate potential, additional research is required to comprehensively comprehend the mechanisms and possible adverse effects of TB-500. 

Disclaimer

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PLEASE NOTE: All products offered by RCD.bio are strictly intended for laboratory and research purposes only. They are not intended for use on animals or humans.