Theacrine, teacrine in some, refers to a naturally occurring alkaloid present in some teas and coffees, most notably the tea plant Camellia assamica var. kucha. While similar to caffeine, Theacrine is believed to offer potential health benefits beyond what caffeine can provide. Specifically, research has suggested that Theacrine may help improve fatigue, cognitive function, anxiety, stamina, stress, and other health concerns.

However, while initial findings are promising, further research is necessary to confirm these benefits and establish the safety and efficacy of Theacrine for use in treating various health conditions.

Theacrine Product Details

Theacrine, also known as Teacrine (a patent-pending compound), is a naturally occurring compound that is gaining attention for its purported ability to enhance mental and physical energy. It is often referred to as an energy-boosting ingredient. Theacrine is a nature-identical compound, meaning it is chemically identical to the compound found in natural sources such as caffeine.

One of the key properties of this chemical is that theacrine promotes one’s motivation and may even improve energy levels. Some research even claims that theacrine supports feelings of alertness because it may interact with certain receptors in the brain.

Despite the seeming health advantages theacrine may bring, it is not considered as an approved focus support supplement or even a safe dietary supplement for humans. Purchase this product for research studies only.

Key Features of Theacrine

  • 98% Purity
  • 1g | 5g | 10g
  • The mechanism of action is quite similar to caffeine

Potential Benefits of Theacrine

Theacrine’s Potential in Pain Reduction

A study conducted in 2010 examined the anti-inflammatory and analgesic effects of Theacrine using a hot plate sensitivity test. The findings suggest that even a low dose of Theacrine, as little as 8mg per kilogram of body weight, may have the potential to reduce pain sensitivity. [R]

In lab mice, Theacrine exhibited comparable potency to the anti-inflammatory drug indomethacin and showed dose-dependent pain-relieving properties. Notably, caffeine did not exhibit similar effects. While these initial findings are promising, further research is necessary to determine the full extent of Theacrine’s effectiveness as an analgesic. [R]

Theacrine’s Impact on Energy Levels

A controlled laboratory study investigated the effects of a single 200mg dose of Theacrine and reported subjective improvements in energy levels, focus, mental clarity, exercise motivation, and libido. Theacrine was found to significantly increase physical activity in rats, likely mediated by the adenosine and dopamine systems. Although the available research suggests that Theacrine can boost energy levels, larger and well-designed studies are needed to provide further confirmation. [R] [R]

Theacrine’s Influence on Mood

Elevated dopamine levels are associated with increased energy, enhanced mood, and pleasurable sensations. In rats, Theacrine activates dopamine receptors DRD1 and DRD2, while also stimulating activity in the brain’s nucleus accumbens region, which is linked to pleasure and reward. Another study comparing a supplement containing both Theacrine and caffeine to caffeine alone or a placebo reported improvements in long-lasting energy, mood, reduced brain fog, and decreased lethargy. [R]

However, additional research is necessary to establish the full extent of Theacrine’s mood-enhancing effects. [R]

Theacrine’s Potential for Relaxation

Animal studies suggest that low doses of Theacrine (less than 100mg) may have mild sedative and hypnotic effects. When administered alongside the sedative pentobarbital, these low doses of Theacrine prolonged sleep duration in mice. It is important to note that these findings in animal studies do not directly translate to humans, but they do highlight a potentially distinct characteristic of Theacrine compared to other stimulants like caffeine, warranting further exploration. [R]

Theacrine’s Impact on Endurance and Mental Performance

A 2019 study involving elite male and female soccer players used a simulated treadmill soccer match to assess the effects of Theacrine. The participants were divided into different groups and received various supplements, including Theacrine, caffeine, a combination of Theacrine and caffeine, or a placebo. The study measured time to exhaustion (a marker of endurance) and reaction time under different conditions. [R]

The results indicated that both Theacrine and caffeine increased time until exhaustion to a similar extent, while the combination of the two compounds further enhanced endurance compared to individual use. [R]

How It Works

Theacrine exerts its effects on the human body through various mechanisms of action, contributing to its benefits and distinct properties.

One of the key mechanisms is its interaction with adenosine receptors. Adenosine is a neurotransmitter that plays a role in regulating sleep, promoting relaxation, and dilating blood vessels, thereby lowering blood pressure.

Theacrine, similar to caffeine, can bind to adenosine receptors, leading to increased alertness and reduced feelings of fatigue. The main difference between Theacrine is its slower development of tolerance at a much slower pace compared to caffeine. Although caffeine tolerance begins to set in a few days, studies indicate that Theacrine does not cause tolerance even after a week of daily consumption.

Another aspect of Theacrine’s mechanism of action lies in its ability to affect two neural pathways: the dopaminergic and adenosinergic systems. By influencing these pathways, Theacrine noticeably supports mental clarity, focus, and motivation, providing an energy boost that can help individuals attain peak performance.

Importantly, Theacrine offers a unique advantage over caffeine in that it appears to have a slower onset and longer duration of action. This slower onset may contribute to a reduced likelihood of tolerance forming, which means individuals may not build up a tolerance to Theacrine as quickly as they do with caffeine. Consequently, Theacrine can provide sustained energy throughout the day without the need for increasing doses or experiencing diminished effects over time.

The scientific basis behind the benefits of Theacrine stems from both preclinical and human studies. Preclinical research suggests that Theacrine enhances energy production by influencing cellular pathways involved in metabolism. It has been shown to increase cellular levels of cAMP (cyclic adenosine monophosphate), which plays a crucial role in energy metabolism and signaling within cells.

In human studies, the subjective reports of increased energy, improved focus, and enhanced motivation following Theacrine supplementation provide further support for its benefits. Moreover, research comparing Theacrine to caffeine has shown that individuals who were already tolerant to caffeine experienced the same results with Theacrine, suggesting that it can provide similar energy-boosting effects even in individuals with a high caffeine tolerance.


While Theacrine shows promise as a potent pending compound, it is important to consider certain test subjects who may not be suitable candidates for its use.

Pregnant or nursing women: Due to the limited human clinical research available on Theacrine’s effects during pregnancy or lactation, it is recommended that these individuals avoid its use to ensure the safety of both mother and child.

Individuals with cardiovascular conditions: Since Theacrine can influence heart rate and blood pressure, individuals with cardiovascular conditions should exercise caution. It is advisable for them to consult a healthcare practitioner before considering Theacrine supplementation, as it may have adverse effects on their condition.

Individuals sensitive to stimulants: Theacrine has a multi-pronged effect on the body, including increasing energy levels and mental alertness. However, some individuals may be more sensitive to stimulants, and high doses of Theacrine may lead to jitteriness, restlessness, or an increased heart rate. It is recommended that those with sensitivity to stimulants or a history of adverse reactions to similar compounds proceed with caution.

Those with pre-existing caffeine sensitivity or tolerance: As Theacrine shares some similarities with caffeine, individuals who already have a high tolerance to caffeine may not experience the same level of energy-boosting effects from Theacrine. In such cases, the benefits of Theacrine supplementation may be limited, and alternatives like coffee or other caffeinated beverages may work better for them.

Children: Theacrine has not been extensively studied in pediatric populations, and its safety and efficacy in children have not been established. Therefore, it is recommended to avoid Theacrine use in individuals below the age of 18 unless specifically directed by a healthcare practitioner.

Potential Side Effects

Theacrine, when used as a pure compound, has generally been regarded as safe for consumption. It is well-tolerated by most test subjects and does not exhibit significant adverse effects on healthy bodily functions. Theacrine’s impact on physical energy is similar to caffeine, making it a potential alternative for those seeking an energy boost without the drawbacks associated with caffeine.

However, it is important to note that individual responses may vary, and it is advisable to note any kind of adverse reactions to this research chemical. This information is for educational purposes only and should not be considered a substitute for professional medical advice.

Legal Disclaimer: The statements made have not been evaluated by the Food and Drug Administration (FDA). This product is not intended to diagnose, treat, cure, or prevent any disease.


In conclusion, Theacrine offers several potential benefits that make it an intriguing compound. Caffeine supports focus which is also something theacrine could offer. Unlike caffeine, which may lead to tolerance build-up over time, Theacrine could be an alternative. This claim is based on its alleged ability to promote mental clarity, improved motivation, and feelings of energy to support a more focused and productive mindset.

Theacrine activates similar signaling pathways as caffeine, but its effects are often described as smoother and without the jitters or crashes commonly associated with excessive caffeine consumption. While more clinical studies are needed to fully understand its mechanisms and effects, preliminary evidence suggests that Theacrine’s impact on healthy functions is promising. also sells Theacrine in powder and tablet form for research purposes. 


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