Tianeptine Ethyl Ester Sulfate Powder is a modified form of Tianeptine, a well-known anxiolytic compound utilized for managing symptoms of anxiety and depression. This chemical variant, Tianeptine Ethyl Ester Sulfate, is specifically designed to enhance its bioavailability and efficacy, making it a potentially more effective option for those seeking relief from mood-related disorders.

The key advantages of using Tianeptine Ethyl Ester Sulfate Powder encompass its superior absorption, mood-regulating properties, the potential for reducing depression symptoms, stress-reduction capabilities, and the possibility of requiring lower doses, thereby minimizing the risk of adverse effects associated with higher amounts.

Tianeptine Ethyl Ester Sulfate Powder Product Details

Tianeptine Ethyl Ester Sulfate Powder is a refined derivative of Tianeptine with a molecular weight of 465.0 g/mol, which offers distinct advantages. It Unlike its hygroscopic counterpart, this sulfate salt is notably easier to handle. What sets it apart is its unique pharmacokinetics – it is less rapidly absorbed and excreted from the body. As a result, Tianeptine Ethyl Ester Sulfate facilitates a controlled, sustained release of Tianeptine, extending its effects over more extended periods.

IUPAC NAME: 7-[(3-chloro-6-methyl-5,5-dioxo-11H-benzo[c][2,1]benzothiazepin-11-yl)amino]heptanoate

Synonyms: ethyl 7-[(3-chloro-6-methyl-5,5-dioxo-11H-benzo[c][2,1]benzothiazepin-11-yl)amino]heptanoate, Ethyl 7-(((11RS)-3-chloro-6-methyl-6,11-dihydrodibenzo(c,f)(1,2)thiazepin-11-yl)amino)heptanoate S,S-dioxide, Heptanoic acid, 7-((3-chloro-6,11-dihydro-6-methyl-5,5-dioxidodibenzo(c,f)(1,2)thiazepin-11-yl)amino)-, ethyl ester, Heptanoic acid, 7-((3-chloro-6,11-dihydro-6-methyldibenzo(c,f)(1,2)thiazepin-11-yl)amino)-, ethyl ester, S,S-dioxide, Ethyl Tianeptate, Heptanoic acid, 7-[(3-chloro-6,11-dihydro-6-methyl-5,5-dioxidodibenzo[c,f][1,2]thiazepin-11-yl)amino]-, ethyl ester

Key Features of Tianeptine Ethyl Ester Sulfate Powder

  • 98% Product Purity
  • 2g
  • Sold for research purposes only

Potential Benefits of Tianeptine Ethyl Ester Sulfate Powder

Tianeptine and its Impact on Depression

Tianeptine, an antidepressant with characteristics akin to amitriptyline, imipramine, and fluoxetine, has demonstrated its efficacy in combatting major depressive episodes while maintaining a notably lower incidence of adverse effects. In cases where participants grapple with both major depression and anxiety simultaneously, Tianeptine has proven more advantageous than maprotiline.

Research underscores its significant anxiolytic properties, offering a possibly effective relief for various anxiety disorders, including panic disorder. [R]

Remarkably, Tianeptine exhibits panic-blocking effects similar to those observed when using paroxetine in conjunction with 35% CO2 gas (carbogen). Furthermore, Tianeptine may enhance cognitive function in test subjects with depression-related cognitive impairment, a trait it shares with numerous other antidepressants such as bupropion, selective serotonin reuptake inhibitors, and serotonin-norepinephrine reuptake inhibitors. [R]

Tianeptine’s Impact on Asthma

Tianeptine has shown promise in treating asthma and respiratory depression. A noteworthy 52-week randomized controlled study conducted on asthmatic participants demonstrated significant clinical improvement and enhanced lung function in groups administered with Tianeptine, as reported by Dr. Fuad Lechin and colleagues at the Central University of Venezuela Institute of Experimental Medicine in Caracas. [R]

This research unearthed a substantial correlation between plasma-free serotonin levels and the severity of asthma symptoms observed two years prior. Tianeptine, known for its ability to lower plasma-free serotonin levels and enhance serotonin uptake in platelets, was chosen for investigation. By November 2004, two double-blind placebo-controlled crossover trials and a seven-year open-label study involving over 25,000 participants confirmed its efficacy. [R]

How It Works

Tianeptine Ethyl Ester Sulfate’s mechanism of action can be explained in simpler terms. Recent research indicates that this compound acts as a key, fitting into a specific lock in the brain known as the mu-type opioid receptor, which scientists are exploring as a target for new antidepressant therapies. This interaction with opioid receptors is believed to be a key part of how Tianeptine works.

But Tianeptine doesn’t stop there; it also influences other important brain signals. It changes the way receptors for chemicals like serotonin, dopamine, and glutamate function. This modulation affects how these chemicals communicate in the brain, which plays a role in regulating mood and emotions.

Tianeptine has a unique ability to alter the wiring of our brains, a process known as “neural plasticity.” It does this by affecting receptors called AMPA and NMDA, essentially rewiring the brain to think more positively and adapt to stress more effectively.

Additionally, Tianeptine helps to reduce the impact of stress by influencing glutamate levels in brain regions associated with emotions and memories. When we’re stressed, our brains can go into overdrive, leading to various issues, but Tianeptine helps to calm this stress response.

Tianeptine boosts serotonin levels in the brain, which is a chemical that significantly affects our mood. This increase in serotonin can contribute to an overall improvement in our mental well-being.


When researching the use of Tianeptine Ethyl Ester Sulfate, it is essential to take certain precautions. Here are some precautions to keep in mind:

Observe best practices for studying research chemicals

Studying research chemicals requires a responsible and informed approach to ensure safety and meaningful scientific exploration. Research chemicals, also known as designer drugs or experimental compounds, are substances synthesized for scientific investigation or exploration of their properties.

Follow the recommended dosage

Adhere to the recommended dosage instructions outlined on the product label. Avoid exceeding the suggested dose to minimize the risk of potential adverse effects among test subjects.

Potential Side Effects

Potential side effects of using Tianeptine Ethyl Ester Sulfate may include nausea, dizziness, dry mouth, constipation, and in some cases, an increased risk of addiction or withdrawal symptoms when taken in high doses or over an extended period. Users should exercise caution, adhere to recommended dosages, and consult with a healthcare professional before considering its use, as the safety profile of Tianeptine Ethyl Ester Sulfate is still a subject of ongoing research.


Tianeptine Ethyl Ester Sulfate offers a range of benefits in managing various conditions. It stands out for its effectiveness in alleviating major depressive episodes with fewer side effects, making it a valuable alternative to traditional antidepressants.

Additionally, Tianeptine demonstrates significant anxiolytic properties, providing a possible relief for anxiety disorders, including panic disorder, and even offering panic-blocking effects in combination with certain therapies. It’s noteworthy for potentially improving cognitive function in test subjects with depression-related cognitive impairment, akin to other antidepressants.

When considering these benefits, it’s essential to buy Tianeptine Ethyl Ester Sulfate powder from a reputable source, ensuring it’s lab-tested and packaged in a double-sealed bag or resealable mylar bag. Stored in a cool, dry place, shielded from outside air, is crucial to maintain its integrity and effectiveness.


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