It is an experimental compound being studied for its cognitive and neuroprotective properties. This nootropic is said to alleviate brain fog, leading to improved focus and motivation, and potentially enhancing overall cognition by boosting cerebral blood flow. The compound may also enhance mental clarity, wakefulness, and mood.

Vincamine is found in some generic drugs. Vincamine for sale is typically available in doses of 1 mg, 5 mg, and 10 mg, used in laboratory-controlled research. Due to the need for further extensive studies, it is recommended to purchase vincamine for research purposes only. It is not advised for human consumption since its potential therapeutic efficacy is still being investigated.

Vincamine Product Details

It is a compound belonging to the group of monoterpenoid indole alkaloids obtained from the Madagascar periwinkle. Most common drug preparations are being practiced in studying vincamine.

Historically, periwinkle has been utilized for alleviating headaches during medieval times. However, it was not until 1953 that the primary component responsible for the plant’s medicinal properties was identified.

This compound acts as a peripheral vasodilator, enhancing blood flow in the brain. It has the potential to support cognitive function and improve memory, concentration, and thinking abilities required for tasks involving focused attention. Additionally, it may have benefits for primary degenerative and vascular dementia.

  • CAS Number 1617-90-9
  • Molar Mass 354.450 g·mol−1
  • Chemical Formula C21H26N2O3
  • IUPAC Name methyl (15S,17S,19S)-15-ethyl-17-hydroxy-1,11-diazapentacyclo[,7.08,18.015,19]nonadeca-2,4,6,8(18)-tetraene-17-carboxylate
  • Synonyms: devincan equipur minorin novicet

Key Features of Vincamine for Sale

  • 98% Purity
  • 1g | 5g
  • Sold for research purposes only

Potential Benefits of Vincamine

Vincamine and Blood Flow to the Brain

Vincamine has been shown to have positive neuropharmacological effects, which contribute to its appeal as a nootropic compound. Patients administered vincamine have exhibited significant increases in global cerebral blood flow and improvements in performance on verbal memory tests. [R]

Additionally, vincamine has demonstrated the ability to decrease ischemic regions, indicating a potential enhancement in blood flow to the brain. These findings suggest that vincamine may have a positive impact on brain health and cognitive performance. [R]

Vincamine and Iron Oxidative Damage

Vincamine has been found to have potential benefits for the elderly by reducing brain iron concentrations, thereby preventing oxidative damage caused by iron to neural cells. Research has demonstrated that vincamine can cross the blood-brain barrier and possesses antioxidant properties comparable to Vitamin E. Its ability to scavenge hydroxyl free radicals, an action that helps protect against oxidative stress, has been highlighted. [R] [R]

The accumulation of iron in high concentrations is believed to contribute to oxidative stress and neuronal death in neurodegenerative diseases like Parkinson’s, Alzheimer’s, and Huntington’s. These conditions are characterized by an increased presence of iron in the affected brain regions. By reducing brain iron concentrations, vincamine may help counteract the oxidative damage associated with these diseases. [R] [R]

Vincamine’s Anti-Apoptotic Effects

In a specific study, vincamine, a natural alkaloid, exhibited mitigating effects on the negative consequences of A25-35 in PC12 cells. The compound derived from leaves demonstrated an increase in cell survival, a decrease in apoptosis and cytotoxicity, as well as a reduction in the concentrations/activities of various oxidative stress indicators. These findings suggest a potential anti-apoptotic role for vincamine. [R]

Vincamine’s Effect on Blood Pressure

Animal studies have indicated that both vincamine and ethyl apovincaminate can lower blood pressure while increasing heart rate. This suggests a potential role for vincamine in managing blood pressure levels. However, further research is necessary to fully understand its mechanisms and effects in humans. [R]

Vincamine and Cognitive Function

Intravenous or intramuscular administration of vincamine has shown a significant increase in cerebral metabolism in patients, indicating a potential improvement in cognitive function. By enhancing cerebral metabolism, vincamine may have a positive influence on cognitive processes such as memory, concentration, and thinking abilities. [R]

How It Works

Vincamine exerts its beneficial effects through various mechanisms of action. Firstly, it acts as a potent vasodilator, relaxing smooth muscle cells within the blood vessel walls. This leads to the widening or dilation of the vessels that supply blood to the brain, resulting in increased blood flow. The enhanced blood flow facilitates the delivery of essential nutrients, oxygen, and glucose to the brain, thereby increasing the production of energy and supporting cellular maintenance.

Additionally, vincamine demonstrates another intriguing mechanism by activating the locus coeruleus, a region located in the brain stem. The locus coeruleus plays a role in regulating physiological responses to panic and stress. As we age, the number of neurons in this region tends to decrease, and their effectiveness may decline. Vincamine has the potential to awaken and reactivate these neurons, potentially offsetting some of the age-related cognitive declines. By stimulating the locus coeruleus, vincamine may help modulate stress and panic responses, promoting a more balanced cognitive state.

Through its dual actions of vasodilation and locus coeruleus activation, vincamine offers a multifaceted approach to improving cognitive function. By enhancing blood flow to the brain and potentially restoring neuronal activity in specific regions, vincamine may contribute to enhanced cognitive performance and provide neuroprotective effects, particularly in the context of age-related cognitive decline.


When researching the use of Vincamine, it is essential to take certain precautions. Here are some precautions to keep in mind:

Observe best practices for studying research chemicals: Studying research chemicals requires a responsible and informed approach to ensure safety and meaningful scientific exploration. Research chemicals, also known as designer drugs or experimental compounds, are substances synthesized for scientific investigation or exploration of their properties.

Follow recommended dosage: Adhere to the recommended dosage instructions outlined on the product label. Avoid exceeding the suggested dose to minimize the risk of potential adverse effects among test subjects.

Potential Side Effects

Vincamine is generally well-tolerated and is associated with minimal side effects. Occasionally, it may cause stomach or gastrointestinal issues. However, it is important to note that if someone accidentally takes vincamine and experiences any adverse reactions, it is advisable to seek medical attention. This ensures proper evaluation and guidance in managing and addressing any potential concerns or discomfort that may arise.


In conclusion, Vincamine offers a range of potential benefits for cognitive health and overall well-being. It is a peripheral vasodilator that increases blood flow throughout the body, including the brain, by relaxing smooth muscle cells within blood vessel walls. By crossing the blood-brain barrier, Vincamine has the potential to play a role in maintaining cognitive function, making it particularly relevant for conditions such as degenerative and vascular dementia.

As an indole alkaloid found in plants like Vinca minor, Vincamine possesses antioxidant properties and the ability to scavenge reactive oxygen species, such as inactivate hydroxyl free radicals. This molecular formula contributes to its antioxidant scavenging capacity, which can help protect neural cells from oxidative damage.

Furthermore, Vincamine has been associated with potential benefits like improving memory and thinking ability. By enhancing blood flow and nutrient supply to the brain, Vincamine supports cognitive processes necessary for concentration, memory formation, and overall mental performance.


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